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RGS22 regulator of G protein signaling 22 [ Homo sapiens (human) ]

Gene ID: 26166, updated on 5-Aug-2022

Summary

Official Symbol
RGS22provided by HGNC
Official Full Name
regulator of G protein signaling 22provided by HGNC
Primary source
HGNC:HGNC:24499
See related
Ensembl:ENSG00000132554 MIM:615650; AllianceGenome:HGNC:24499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT145; PRTD-NY2
Summary
Enables G-protein alpha-subunit binding activity. Predicted to be involved in negative regulation of signal transduction. Located in actin cytoskeleton; cytosol; and fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 35.2), ovary (RPKM 3.9) and 1 other tissue See more
Orthologs
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Try the new Transcript table

Genomic context

See RGS22 in Genome Data Viewer
Location:
8q22.2
Exon count:
32
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (99960936..100106049, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (101085830..101230841, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (100973164..101118277, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 13 homolog B Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 pseudogene 3 Neighboring gene cytochrome c oxidase subunit 6C Neighboring gene small nucleolar RNA, C/D box 77B Neighboring gene F-box protein 43 Neighboring gene RNA polymerase II, I and III subunit K

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ40080, FLJ75004, MGC102908, DKFZp434I092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
regulator of G-protein signaling 22

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286692.2NP_001273621.1  regulator of G-protein signaling 22 isoform 2

    See identical proteins and their annotated locations for NP_001273621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK292559, AP005356, BC092411, BM684810
    Consensus CDS
    CCDS69521.1
    UniProtKB/Swiss-Prot
    Q8NE09
    Related
    ENSP00000428212.1, ENST00000523437.5
    Conserved Domains (3) summary
    cd08725
    Location:10141136
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:841970
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:658773
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
  2. NM_001286693.2NP_001273622.1  regulator of G-protein signaling 22 isoform 3

    See identical proteins and their annotated locations for NP_001273622.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC021590, AP005356, BC050053, BM684810
    Consensus CDS
    CCDS75775.1
    UniProtKB/TrEMBL
    G3V112
    Related
    ENSP00000429382.1, ENST00000523287.5
    Conserved Domains (3) summary
    cd08725
    Location:845967
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:672801
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:489604
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
  3. NM_015668.5NP_056483.3  regulator of G-protein signaling 22 isoform 1

    See identical proteins and their annotated locations for NP_056483.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC021590, AP005356, BC036665, BM684810
    Consensus CDS
    CCDS43758.1
    UniProtKB/Swiss-Prot
    Q8NE09, Q9UFN6
    Related
    ENSP00000354109.6, ENST00000360863.11
    Conserved Domains (3) summary
    cd08725
    Location:10261148
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:853982
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:670785
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    99960936..100106049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013310.3XP_016868799.1  regulator of G-protein signaling 22 isoform X7

  2. XM_017013309.3XP_016868798.1  regulator of G-protein signaling 22 isoform X5

  3. XM_005250856.4XP_005250913.1  regulator of G-protein signaling 22 isoform X2

    Conserved Domains (3) summary
    cd08725
    Location:9731095
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08727
    Location:670785
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:853931
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  4. XM_047421681.1XP_047277637.1  regulator of G-protein signaling 22 isoform X6

  5. XM_005250858.4XP_005250915.1  regulator of G-protein signaling 22 isoform X3

    Conserved Domains (3) summary
    cd08726
    Location:853982
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:670785
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:10051094
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  6. XM_005250857.4XP_005250914.1  regulator of G-protein signaling 22 isoform X1

    Conserved Domains (3) summary
    cd08726
    Location:853982
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:670785
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:10261120
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  7. XM_047421679.1XP_047277635.1  regulator of G-protein signaling 22 isoform X4

  8. XM_017013311.2XP_016868800.1  regulator of G-protein signaling 22 isoform X9

  9. XM_024447121.2XP_024302889.1  regulator of G-protein signaling 22 isoform X11

    Related
    ENST00000517769.5
    Conserved Domains (3) summary
    cd08725
    Location:415537
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:242371
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:59174
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
  10. XM_005250860.4XP_005250917.1  regulator of G-protein signaling 22 isoform X8

    Conserved Domains (1) summary
    cd08727
    Location:670785
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
  11. XM_047421682.1XP_047277638.1  regulator of G-protein signaling 22 isoform X12

  12. XM_011516959.4XP_011515261.1  regulator of G-protein signaling 22 isoform X10

    Conserved Domains (1) summary
    cl02565
    Location:670722
    RGS; Regulator of G protein signaling (RGS) domain superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    101085830..101230841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)