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EPC2 enhancer of polycomb homolog 2 [ Homo sapiens (human) ]

Gene ID: 26122, updated on 9-Sep-2018

Summary

Official Symbol
EPC2provided by HGNC
Official Full Name
enhancer of polycomb homolog 2provided by HGNC
Primary source
HGNC:HGNC:24543
See related
Ensembl:ENSG00000135999 MIM:611000; Vega:OTTHUMG00000153739
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPC-LIKE
Expression
Ubiquitous expression in ovary (RPKM 10.6), endometrium (RPKM 9.8) and 25 other tissues See more
Orthologs

Genomic context

See EPC2 in Genome Data Viewer
Location:
2q23.1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (148644780..148788491)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (149402560..149545136)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene methyl-CpG binding domain protein 5 Neighboring gene ADP ribosylation factor like GTPase 5A pseudogene Neighboring gene ribosomal protein S29 pseudogene 8 Neighboring gene uncharacterized LOC101928526 Neighboring gene RNA, U2 small nuclear 9, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
NHGRI GWA Catalog
Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp566F2124

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
histone acetylation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Piccolo NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
enhancer of polycomb homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015630.3NP_056445.3  enhancer of polycomb homolog 2

    See identical proteins and their annotated locations for NP_056445.3

    Status: VALIDATED

    Source sequence(s)
    AK125789
    Consensus CDS
    CCDS46422.1
    UniProtKB/Swiss-Prot
    Q52LR7
    Related
    ENSP00000258484.6, OTTHUMP00000204350, ENST00000258484.10, OTTHUMT00000332278
    Conserved Domains (2) summary
    pfam06752
    Location:577807
    E_Pc_C; Enhancer of Polycomb C-terminus
    pfam10513
    Location:7148
    EPL1; Enhancer of polycomb-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    148644780..148788491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510941.2XP_011509243.1  enhancer of polycomb homolog 2 isoform X1

    Conserved Domains (2) summary
    pfam06752
    Location:575805
    E_Pc_C; Enhancer of Polycomb C-terminus
    pfam10513
    Location:7148
    EPL1; Enhancer of polycomb-like
  2. XM_011510943.3XP_011509245.1  enhancer of polycomb homolog 2 isoform X2

    Conserved Domains (2) summary
    pfam06752
    Location:488718
    E_Pc_C; Enhancer of Polycomb C-terminus
    pfam10513
    Location:2659
    EPL1; Enhancer of polycomb-like
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