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SZRD1 SUZ RNA binding domain containing 1 [ Homo sapiens (human) ]

Gene ID: 26099, updated on 13-Mar-2020

Summary

Official Symbol
SZRD1provided by HGNC
Official Full Name
SUZ RNA binding domain containing 1provided by HGNC
Primary source
HGNC:HGNC:30232
See related
Ensembl:ENSG00000055070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf144
Expression
Ubiquitous expression in fat (RPKM 37.2), endometrium (RPKM 33.9) and 25 other tissues See more
Orthologs

Genomic context

See SZRD1 in Genome Data Viewer
Location:
1p36.13
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (16367242..16398145)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (16693525..16724643)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene metallothionein 1X pseudogene 1 Neighboring gene F-box protein 42 Neighboring gene ribosomal protein L22 pseudogene 3 Neighboring gene spermatogenesis associated 21 Neighboring gene NECAP endocytosis associated 2 Neighboring gene long intergenic non-protein coding RNA 1772 Neighboring gene CROCC pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC70432, DKFZp566C0424

General protein information

Preferred Names
SUZ domain-containing protein 1
Names
UPF0485 protein C1orf144
putative MAPK activating protein PM20,PM21
putative MAPK-activating protein PM18/PM20/PM22

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114600.3NP_001108072.1  SUZ domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001108072.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB097046, AL358794, BC010631, DB501645
    Consensus CDS
    CCDS44065.1
    UniProtKB/Swiss-Prot
    Q7Z422
    Related
    ENSP00000383866.4, ENST00000401088.9
    Conserved Domains (2) summary
    pfam12752
    Location:56107
    SUZ; SUZ domain
    pfam12901
    Location:135150
    SUZ-C; SUZ-C motif
  2. NM_001271869.2NP_001258798.1  SUZ domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001258798.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL358794, BC010631, DA010145
    Consensus CDS
    CCDS60000.1
    UniProtKB/Swiss-Prot
    Q7Z422
    Related
    ENSP00000419589.1, ENST00000471507.5
    Conserved Domains (2) summary
    pfam12752
    Location:55106
    SUZ; SUZ domain
    pfam12901
    Location:134149
    SUZ-C; SUZ-C motif

RNA

  1. NR_073500.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AK308787, AL358794, BC010631, DB501645
  2. NR_073501.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL358794, BC010631, DA438597, DB501645
  3. NR_073502.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL358794, BC010631, BC023988
    Related
    ENST00000401089.3
  4. NR_073503.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal exon and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB097044, AL358794, BC010631, DB501645
    Related
    ENST00000492354.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    16367242..16398145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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