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SLITRK5 SLIT and NTRK like family member 5 [ Homo sapiens (human) ]

Gene ID: 26050, updated on 5-Aug-2018

Summary

Official Symbol
SLITRK5provided by HGNC
Official Full Name
SLIT and NTRK like family member 5provided by HGNC
Primary source
HGNC:HGNC:20295
See related
Ensembl:ENSG00000165300 MIM:609680; Vega:OTTHUMG00000017167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRC11; bA364G4.2
Summary
Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in brain (RPKM 5.9), thyroid (RPKM 2.1) and 4 other tissues See more
Orthologs

Genomic context

See SLITRK5 in Genome Data Viewer
Location:
13q31.2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (87671232..87679619)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (88323931..88331871)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370302 Neighboring gene LIN28A pseudogene 2 Neighboring gene MIR4500 host gene Neighboring gene microRNA 4500 Neighboring gene uncharacterized LOC112268106 Neighboring gene nudix hydrolase 21 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ58374, KIAA0918

Gene Ontology Provided by GOA

Process Evidence Code Pubs
adult behavior IEA
Inferred from Electronic Annotation
more info
 
axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cardiovascular system development IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
grooming behavior IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
skin development IEA
Inferred from Electronic Annotation
more info
 
striatum development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SLIT and NTRK-like protein 5
Names
leucine rich repeat containing 11
leucine-rich repeat-containing protein 11
slit and trk like gene 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015567.1NP_056382.1  SLIT and NTRK-like protein 5 precursor

    See identical proteins and their annotated locations for NP_056382.1

    Status: VALIDATED

    Source sequence(s)
    AB020725, AK024251, AW449813
    Consensus CDS
    CCDS9465.1
    UniProtKB/Swiss-Prot
    O94991
    Related
    ENSP00000366283.2, OTTHUMP00000018547, ENST00000325089.7, OTTHUMT00000045416
    Conserved Domains (7) summary
    smart00082
    Location:235273
    LRRCT; Leucine rich repeat C-terminal domain
    PRK05641
    Location:581655
    PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
    sd00031
    Location:435458
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:6279
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:457498
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:433493
    LRR_8; Leucine rich repeat
    cl15307
    Location:563599
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    87671232..87679619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254038.5XP_005254095.1  SLIT and NTRK-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_005254095.1

    UniProtKB/Swiss-Prot
    O94991
    Conserved Domains (7) summary
    smart00082
    Location:235273
    LRRCT; Leucine rich repeat C-terminal domain
    PRK05641
    Location:581655
    PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
    sd00031
    Location:435458
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:6279
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:457498
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:433493
    LRR_8; Leucine rich repeat
    cl15307
    Location:563599
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  2. XM_005254039.2XP_005254096.1  SLIT and NTRK-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_005254096.1

    UniProtKB/Swiss-Prot
    O94991
    Conserved Domains (7) summary
    smart00082
    Location:235273
    LRRCT; Leucine rich repeat C-terminal domain
    PRK05641
    Location:581655
    PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
    sd00031
    Location:435458
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:6279
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:457498
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:433493
    LRR_8; Leucine rich repeat
    cl15307
    Location:563599
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
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