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FDCSP follicular dendritic cell secreted protein [ Homo sapiens (human) ]

Gene ID: 260436, updated on 23-Nov-2021

Summary

Official Symbol
FDCSPprovided by HGNC
Official Full Name
follicular dendritic cell secreted proteinprovided by HGNC
Primary source
HGNC:HGNC:19215
See related
Ensembl:ENSG00000181617 MIM:607241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4orf7; FDC-SP
Summary
This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011]
Expression
Biased expression in salivary gland (RPKM 447.2), lymph node (RPKM 235.7) and 1 other tissue See more
Orthologs
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Genomic context

See FDCSP in Genome Data Viewer
Location:
4q13.3; 4q13
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (70226124..70235252)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71091841..71100969)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377270 Neighboring gene odontogenic, ameloblast associated Neighboring gene casein kappa Neighboring gene calcium binding protein, spermatid associated 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71894

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
follicular dendritic cell secreted peptide
Names
FDC secreted protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152997.4NP_694542.1  follicular dendritic cell secreted peptide precursor

    See identical proteins and their annotated locations for NP_694542.1

    Status: REVIEWED

    Source sequence(s)
    AY190326
    Consensus CDS
    CCDS3537.1
    UniProtKB/Swiss-Prot
    Q8NFU4
    UniProtKB/TrEMBL
    Q540F3
    Related
    ENSP00000318437.5, ENST00000317987.6
    Conserved Domains (1) summary
    pfam15215
    Location:1882
    FDC-SP; Follicular dendritic cell secreted peptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    70226124..70235252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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