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Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 260302, updated on 23-Dec-2022

Summary

Official Symbol
Gga3provided by MGI
Official Full Name
golgi associated, gamma adaptin ear containing, ARF binding protein 3provided by MGI
Primary source
MGI:MGI:2384159
See related
Ensembl:ENSMUSG00000020740 AllianceGenome:MGI:2384159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0154; C230037M19Rik
Summary
Predicted to enable small GTPase binding activity and ubiquitin binding activity. Acts upstream of or within positive regulation of protein catabolic process and protein localization to lysosome. Predicted to be located in endosome; lysosome; and trans-Golgi network. Predicted to be part of protein-containing complex. Is expressed in several structures, including heart; liver; lung; metanephros; and white fat. Orthologous to human GGA3 (golgi associated, gamma adaptin ear containing, ARF binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 30.1), spleen adult (RPKM 15.7) and 28 other tissues See more
Orthologs
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Genomic context

See Gga3 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115475081..115495501, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115584255..115604517, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene small ubiquitin-like modifier 2 Neighboring gene nucleoporin 85 Neighboring gene predicted gene, 25364 Neighboring gene mitchondrial ribosomal protein S7 Neighboring gene MIF4G domain containing Neighboring gene solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein targeting to lysosome ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ADP-ribosylation factor-binding protein GGA3
Names
golgi-localized, gamma ear-containing, ARF-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252067.2NP_001238996.1  ADP-ribosylation factor-binding protein GGA3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AL645470
    Consensus CDS
    CCDS56817.1
    UniProtKB/TrEMBL
    A2A9W7
    Related
    ENSMUSP00000102117.4, ENSMUST00000106508.10
    Conserved Domains (3) summary
    smart00809
    Location:518632
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd03567
    Location:8146
    VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
    cd14240
    Location:213299
    GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3
  2. NM_173048.4NP_766636.2  ADP-ribosylation factor-binding protein GGA3 isoform 1

    See identical proteins and their annotated locations for NP_766636.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL645470
    Consensus CDS
    CCDS25641.1
    UniProtKB/Swiss-Prot
    Q80U71, Q8BMI3
    Related
    ENSMUSP00000019135.8, ENSMUST00000019135.14
    Conserved Domains (3) summary
    smart00809
    Location:596710
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd03567
    Location:8146
    VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
    cd14240
    Location:213299
    GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115475081..115495501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533365.5XP_006533428.1  ADP-ribosylation factor-binding protein GGA3 isoform X1

    Conserved Domains (5) summary
    PHA03247
    Location:334669
    PHA03247; large tegument protein UL36; Provisional
    cd14240
    Location:213299
    GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3
    cd17008
    Location:6146
    VHS_GGA3; VHS (Vps27/Hrs/STAM) domain of ADP-ribosylation factor-binding protein GGA3
    pfam02883
    Location:593682
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam18308
    Location:169207
    GGA_N-GAT; GGA N-GAT domain
  2. XM_011249031.3XP_011247333.1  ADP-ribosylation factor-binding protein GGA3 isoform X2

    Conserved Domains (4) summary
    smart00809
    Location:460574
    Alpha_adaptinC2; Adaptin C-terminal domain
    PHA03247
    Location:198533
    PHA03247; large tegument protein UL36; Provisional
    cd14240
    Location:77163
    GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3
    pfam18308
    Location:3371
    GGA_N-GAT; GGA N-GAT domain
  3. XM_011249032.1XP_011247334.1  ADP-ribosylation factor-binding protein GGA3 isoform X3

    Conserved Domains (3) summary
    smart00809
    Location:366480
    Alpha_adaptinC2; Adaptin C-terminal domain
    PHA03247
    Location:104439
    PHA03247; large tegument protein UL36; Provisional
    cd14240
    Location:169
    GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3

RNA

  1. XR_388465.5 RNA Sequence

    Related
    ENSMUST00000156173.8
  2. XR_004936965.1 RNA Sequence