Otos otospiralin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Otosprovided by MGI
Official Full Name: otospiralinprovided by MGI
Primary source: MGI:MGI:2672814
See related: Ensembl:ENSMUSG00000044055 AllianceGenome:MGI:2672814
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OTOSP
Summary: Acts upstream of or within sensory perception of sound. Predicted to be located in extracellular region. Is expressed in inner ear mesenchyme and spiral ligament. Orthologous to human OTOS (otospiralin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 46.55 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (92571940..92576630, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (92644218..92648899, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Collectively, our observations suggest that otospiralin is possibly involved in signaling pathways, and could play a role in repair mechanisms subsequent to an injury in the central nervous system.
Title: Is otospiralin inner ear specific? Evidence for its expression in mouse brain.
Data suggest that impairment of fibrocytes caused by the loss in otospiralin leads to abnormal cochlear physiology and auditory function.
Title: Deafness and cochlear fibrocyte alterations in mice deficient for the inner ear protein otospiralin.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: otospiralin

Names: organ of Corti 10 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153114.2 → NP_694754.1 otospiralin precursor

See identical proteins and their annotated locations for NP_694754.1

Status: PROVISIONAL

Source sequence(s)

BC100323

Consensus CDS

CCDS35668.1

UniProtKB/Swiss-Prot

Q8R448

UniProtKB/TrEMBL

Q497Y7

Related

ENSMUSP00000061683.4, ENSMUST00000053144.4

Conserved Domains (1) summary

pfam15182
Location:21 → 89

OTOS; Otospiralin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

92571940..92576630 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320818.3 → XP_017176307.1 otospiralin isoform X1

UniProtKB/Swiss-Prot

Q8R448

UniProtKB/TrEMBL

Q497Y7

Conserved Domains (1) summary

pfam15182
Location:21 → 89

OTOS; Otospiralin
XM_017320815.2 → XP_017176304.1 otospiralin isoform X1

UniProtKB/Swiss-Prot

Q8R448

UniProtKB/TrEMBL

Q497Y7

Conserved Domains (1) summary

pfam15182
Location:21 → 89

OTOS; Otospiralin