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TMEM98 transmembrane protein 98 [ Homo sapiens (human) ]

Gene ID: 26022, updated on 13-May-2022

Summary

Official Symbol
TMEM98provided by HGNC
Official Full Name
transmembrane protein 98provided by HGNC
Primary source
HGNC:HGNC:24529
See related
Ensembl:ENSG00000006042 MIM:615949; AllianceGenome:HGNC:24529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TADA1
Summary
This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014]
Expression
Ubiquitous expression in ovary (RPKM 69.4), endometrium (RPKM 44.6) and 23 other tissues See more
Orthologs
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Genomic context

See TMEM98 in Genome Data Viewer
Location:
17q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (32928153..32944315)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (33874221..33890387)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (31255171..31271333)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr17.1747 Neighboring gene CRISPRi-validated cis-regulatory element chr17.1750 Neighboring gene Sharpr-MPRA regulatory region 812 Neighboring gene H2B.N variant histone 1 Neighboring gene sperm acrosome associated 3 Neighboring gene uncharacterized LOC105371737 Neighboring gene acid sensing ion channel subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564K1964

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T-helper 1 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034264.1 RefSeqGene

    Range
    5001..18740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001033504.2NP_001028676.1  transmembrane protein 98

    See identical proteins and their annotated locations for NP_001028676.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC084809, AY358573
    Consensus CDS
    CCDS11274.1
    UniProtKB/Swiss-Prot
    Q9Y2Y6
    Related
    ENSP00000378138.3, ENST00000394642.7
    Conserved Domains (1) summary
    pfam13324
    Location:48152
    GCIP; Grap2 and cyclin-D-interacting
  2. NM_001301746.2NP_001288675.1  transmembrane protein 98

    See identical proteins and their annotated locations for NP_001288675.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC084809, AY358573, BQ228781
    Consensus CDS
    CCDS11274.1
    UniProtKB/Swiss-Prot
    Q9Y2Y6
    Related
    ENSP00000406394.1, ENST00000439138.5
    Conserved Domains (1) summary
    pfam13324
    Location:48152
    GCIP; Grap2 and cyclin-D-interacting
  3. NM_015544.3NP_056359.2  transmembrane protein 98

    See identical proteins and their annotated locations for NP_056359.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents a predominant transcript. This variant and variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC084809, AY358573
    Consensus CDS
    CCDS11274.1
    UniProtKB/Swiss-Prot
    Q9Y2Y6
    Related
    ENSP00000463245.1, ENST00000579849.6
    Conserved Domains (1) summary
    pfam13324
    Location:48152
    GCIP; Grap2 and cyclin-D-interacting

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    32928153..32944315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    33874221..33890387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)