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NGDN neuroguidin [ Homo sapiens (human) ]

Gene ID: 25983, updated on 15-Jun-2019

Summary

Official Symbol
NGDNprovided by HGNC
Official Full Name
neuroguidinprovided by HGNC
Primary source
HGNC:HGNC:20271
See related
Ensembl:ENSG00000129460 MIM:610777
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NGD; LCP5; CANu1; lpd-2; C14orf120
Summary
Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 17.4), ovary (RPKM 12.6) and 25 other tissues See more
Orthologs

Genomic context

See NGDN in Genome Data Viewer
Location:
14q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (23469689..23478193)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23938898..23947402)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1670 Neighboring gene VISTA enhancer hs2330 Neighboring gene thiamine triphosphatase Neighboring gene zinc finger homeobox 2 Neighboring gene uncharacterized LOC102724814 Neighboring gene adaptor related protein complex 1 subunit gamma 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564O092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
filopodium IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
neuroguidin
Names
EIF4E-binding protein
centromere accumulated nuclear protein 1
eukaryotic initiation factor 4E and CPEB binding protein
neuroguidin, EIF4E binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042635.2NP_001036100.1  neuroguidin isoform 1

    See identical proteins and their annotated locations for NP_001036100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL132855, BC030817
    Consensus CDS
    CCDS41926.1
    UniProtKB/Swiss-Prot
    Q8NEJ9
    Related
    ENSP00000386134.3, ENST00000408901.8
    Conserved Domains (1) summary
    pfam04000
    Location:1897
    Sas10_Utp3; Sas10/Utp3/C1D family
  2. NM_015514.2NP_056329.1  neuroguidin isoform 2

    See identical proteins and their annotated locations for NP_056329.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) retains an intron, differing in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL132855
    Consensus CDS
    CCDS32051.1
    UniProtKB/Swiss-Prot
    Q8NEJ9
    Related
    ENSP00000380340.3, ENST00000397154.7
    Conserved Domains (1) summary
    pfam04000
    Location:1897
    Sas10_Utp3; Sas10/Utp3/C1D family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    23469703..23478826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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