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PARS2 prolyl-tRNA synthetase 2, mitochondrial [ Homo sapiens (human) ]

Gene ID: 25973, updated on 23-Nov-2021

Summary

Official Symbol
PARS2provided by HGNC
Official Full Name
prolyl-tRNA synthetase 2, mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:30563
See related
Ensembl:ENSG00000162396 MIM:612036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEE75; proRS; EIEE75; MT-PRORS
Summary
This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome. [provided by RefSeq, Mar 2015]
Expression
Ubiquitous expression in testis (RPKM 3.4), ovary (RPKM 2.8) and 24 other tissues See more
Orthologs
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Genomic context

See PARS2 in Genome Data Viewer
Location:
1p32.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (54756898..54764523, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55222571..55230196, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MROH7-TTC4 readthrough (NMD candidate) Neighboring gene maestro heat like repeat family member 7 Neighboring gene tetratricopeptide repeat domain 4 Neighboring gene Sharpr-MPRA regulatory region 10932 Neighboring gene tetratricopeptide repeat domain 22 Neighboring gene lymphocyte expansion molecule

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14416, MGC19467, DKFZp727A071

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables proline-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in prolyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable proline--tRNA ligase, mitochondrial
Names
proline tRNA ligase 2, mitochondrial (putative)
prolyl-tRNA synthetase 2, mitochondrial (putative)
NP_689481.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042048.1 RefSeqGene

    Range
    5031..12656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_152268.4NP_689481.2  probable proline--tRNA ligase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_689481.2

    Status: REVIEWED

    Source sequence(s)
    BC011758, DB004072
    Consensus CDS
    CCDS597.1
    UniProtKB/Swiss-Prot
    Q7L3T8
    Related
    ENSP00000360327.3, ENST00000371279.4
    Conserved Domains (2) summary
    cd00779
    Location:65354
    ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cl00266
    Location:369470
    HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    54756898..54764523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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