Format

Send to:

Choose Destination

TMEM87A transmembrane protein 87A [ Homo sapiens (human) ]

Gene ID: 25963, updated on 1-Jun-2020

Summary

Official Symbol
TMEM87Aprovided by HGNC
Official Full Name
transmembrane protein 87Aprovided by HGNC
Primary source
HGNC:HGNC:24522
See related
Ensembl:ENSG00000103978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 20.9), prostate (RPKM 20.6) and 25 other tissues See more
Orthologs

Genomic context

See TMEM87A in Genome Data Viewer
Location:
15q15.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (42210447..42273584, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42502726..42565797, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group IVF Neighboring gene VPS39 subunit of HOPS complex Neighboring gene uncharacterized LOC105370795 Neighboring gene microRNA 627 Neighboring gene glucosidase alpha, neutral C Neighboring gene BCL2 interacting protein 3 pseudogene 5 Neighboring gene uncharacterized LOC105370794 Neighboring gene calpain 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13507, DKFZp564G2022

Gene Ontology Provided by GOA

Process Evidence Code Pubs
retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde transport, endosome to Golgi IGI
Inferred from Genetic Interaction
more info
PubMed 
transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi cisterna membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi cisterna membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110503.2NP_001103973.1  transmembrane protein 87A isoform 2 precursor

    See identical proteins and their annotated locations for NP_001103973.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC022468, BC005335, HY036655, N63753
    Consensus CDS
    CCDS45243.1
    UniProtKB/Swiss-Prot
    Q8NBN3
    Related
    ENSP00000305894.6, ENST00000307216.10
  2. NM_001286487.1NP_001273416.1  transmembrane protein 87A isoform 3

    See identical proteins and their annotated locations for NP_001273416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF129927, AI434902, BC069240, HY036655
    Consensus CDS
    CCDS66742.1
    UniProtKB/Swiss-Prot
    Q8NBN3
    Related
    ENSP00000405379.1, ENST00000448392.5
    Conserved Domains (1) summary
    pfam06814
    Location:145406
    Lung_7-TM_R; Lung seven transmembrane receptor
  3. NM_015497.5NP_056312.2  transmembrane protein 87A isoform 1 precursor

    See identical proteins and their annotated locations for NP_056312.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC036103, AF129927, AI434902, AK074870
    Consensus CDS
    CCDS32205.1
    UniProtKB/Swiss-Prot
    Q8NBN3
    Related
    ENSP00000374484.4, ENST00000389834.9
    Conserved Domains (1) summary
    pfam06814
    Location:206467
    Lung_7-TM_R; Lung seven transmembrane receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    42210447..42273584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254287.2XP_005254344.1  transmembrane protein 87A isoform X1

    Conserved Domains (1) summary
    pfam06814
    Location:206468
    Lung_7-TM_R; Lung seven transmembrane receptor
  2. XM_011521443.3XP_011519745.1  transmembrane protein 87A isoform X2

    Conserved Domains (1) summary
    pfam06814
    Location:145407
    Lung_7-TM_R; Lung seven transmembrane receptor
  3. XM_017022067.1XP_016877556.1  transmembrane protein 87A isoform X4

  4. XM_006720468.2XP_006720531.1  transmembrane protein 87A isoform X3

    Conserved Domains (1) summary
    pfam06814
    Location:65327
    Lung_7-TM_R; Lung seven transmembrane receptor
  5. XM_011521444.3XP_011519746.1  transmembrane protein 87A isoform X5

    Conserved Domains (1) summary
    cl21735
    Location:206354
    Lung_7-TM_R; Lung seven transmembrane receptor
Support Center