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NOL11 nucleolar protein 11 [ Homo sapiens (human) ]

Gene ID: 25926, updated on 3-May-2020

Summary

Official Symbol
NOL11provided by HGNC
Official Full Name
nucleolar protein 11provided by HGNC
Primary source
HGNC:HGNC:24557
See related
Ensembl:ENSG00000130935 MIM:615366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in lymph node (RPKM 16.4), appendix (RPKM 14.1) and 25 other tissues See more
Orthologs

Genomic context

See NOL11 in Genome Data Viewer
Location:
17q24.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (67717833..67744531)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (65713949..65740319)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein cytoplasmic 1 Neighboring gene microRNA 548aa-2 Neighboring gene microRNA 548d-2 Neighboring gene uncharacterized LOC101928045 Neighboring gene small nucleolar RNA, H/ACA box 38B Neighboring gene Sharpr-MPRA regulatory region 7199 Neighboring gene ribosomal protein SA pseudogene 67

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • DKFZp586L0724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
maturation of SSU-rRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
t-UTP complex IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303272.1NP_001290201.1  nucleolar protein 11 isoform 2

    See identical proteins and their annotated locations for NP_001290201.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC006534, AK299483, AW273123, DA772356
    UniProtKB/Swiss-Prot
    Q9H8H0
    Conserved Domains (1) summary
    pfam08168
    Location:1861
    NUC205; NUC205 domain
  2. NM_015462.5NP_056277.2  nucleolar protein 11 isoform 1

    See identical proteins and their annotated locations for NP_056277.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC006534, AK023702, AK299483, AW273123, DA772356
    Consensus CDS
    CCDS11671.1
    UniProtKB/Swiss-Prot
    Q9H8H0
    Related
    ENSP00000253247.4, ENST00000253247.9
    Conserved Domains (1) summary
    pfam08168
    Location:200243
    NUC205; NUC205 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    67717833..67744531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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