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NOL11 nucleolar protein 11 [ Homo sapiens (human) ]

Gene ID: 25926, updated on 5-Mar-2024

Summary

Official Symbol
NOL11provided by HGNC
Official Full Name
nucleolar protein 11provided by HGNC
Primary source
HGNC:HGNC:24557
See related
Ensembl:ENSG00000130935 MIM:615366; AllianceGenome:HGNC:24557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables RNA binding activity. Involved in maturation of SSU-rRNA and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Located in nucleolus. Part of t-UTP complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 16.4), appendix (RPKM 14.1) and 25 other tissues See more
Orthologs
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Genomic context

See NOL11 in Genome Data Viewer
Location:
17q24.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (67717936..67744531)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (68593485..68619780)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (65714052..65740647)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein cytoplasmic 1 Neighboring gene uncharacterized LOC124904045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12627 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:65595554-65595782 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:65598997-65599506 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:65636212-65636398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12629 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:65651209-65651710 Neighboring gene uncharacterized LOC101928045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:65715225-65715946 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:65717475-65717706 Neighboring gene MPRA-validated peak2955 silencer Neighboring gene Sharpr-MPRA regulatory region 6571 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:65747753-65748532 Neighboring gene Sharpr-MPRA regulatory region 8992 Neighboring gene small nucleolar RNA, H/ACA box 38B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:65764054-65764654 Neighboring gene Sharpr-MPRA regulatory region 7199 Neighboring gene ribosomal protein L17 pseudogene 41 Neighboring gene ribosomal protein SA pseudogene 67

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303272.2NP_001290201.1  nucleolar protein 11 isoform 2

    See identical proteins and their annotated locations for NP_001290201.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC006534, AK299483, AW273123, DA772356
    UniProtKB/Swiss-Prot
    Q9H8H0
    Conserved Domains (1) summary
    pfam08168
    Location:1861
    NUC205; NUC205 domain
  2. NM_015462.5NP_056277.2  nucleolar protein 11 isoform 1

    See identical proteins and their annotated locations for NP_056277.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC006534, AK023702, AK299483, AW273123, DA772356
    Consensus CDS
    CCDS11671.1
    UniProtKB/Swiss-Prot
    B7Z5V9, Q7L5S1, Q9H8H0, Q9UG18
    Related
    ENSP00000253247.4, ENST00000253247.9
    Conserved Domains (1) summary
    pfam08168
    Location:200243
    NUC205; NUC205 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    67717936..67744531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    68593485..68619780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)