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WFDC11 WAP four-disulfide core domain 11 [ Homo sapiens (human) ]

Gene ID: 259239, updated on 25-May-2017
Official Symbol
WFDC11provided by HGNC
Official Full Name
WAP four-disulfide core domain 11provided by HGNC
Primary source
HGNC:HGNC:20478
See related
Ensembl:ENSG00000180083 Vega:OTTHUMG00000046330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WAP11
Summary
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008]
Orthologs
Location:
20q13.12
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (45648563..45670239, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44277202..44298878, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene WAP four-disulfide core domain 9 Neighboring gene WAP four-disulfide core domain 10A Neighboring gene ribosomal protein S2 pseudogene 7 Neighboring gene WAP four-disulfide core domain 10B Neighboring gene WAP four-disulfide core domain 13 Neighboring gene microRNA 3617 Neighboring gene WAP four-disulfide core domain 3 Neighboring gene serine peptidase inhibitor, Kunitz type 4

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Markers

Homology

Clone Names

  • MGC71905

Gene Ontology Provided by GOA

Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein WFDC11
Names
protease inhibitor WAP11

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_147197.2NP_671730.1  protein WFDC11 precursor

    See identical proteins and their annotated locations for NP_671730.1

    Status: REVIEWED

    Source sequence(s)
    AY047609
    Consensus CDS
    CCDS13364.1
    UniProtKB/Swiss-Prot
    Q8NEX6
    Related
    ENSP00000318753.3, OTTHUMP00000043657, ENST00000324384.3, OTTHUMT00000106942

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

    Range
    45648563..45670239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    44179898..44201566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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