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ANAPC15 anaphase promoting complex subunit 15 [ Homo sapiens (human) ]

Gene ID: 25906, updated on 8-Jul-2021

Summary

Official Symbol
ANAPC15provided by HGNC
Official Full Name
anaphase promoting complex subunit 15provided by HGNC
Primary source
HGNC:HGNC:24531
See related
Ensembl:ENSG00000110200 MIM:614717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC15; HSPC020; C11orf51
Expression
Ubiquitous expression in bone marrow (RPKM 6.8), testis (RPKM 5.8) and 25 other tissues See more
Orthologs
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Genomic context

See ANAPC15 in Genome Data Viewer
Location:
11q13.4
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (72106372..72112780, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71817418..71823826, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 51 Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene transmembrane O-methyltransferase Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 6 Neighboring gene folate receptor gamma

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564M082

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic cell cycle spindle assembly checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mitotic cell cycle spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
anaphase-promoting complex subunit 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278485.2NP_001265414.1  anaphase-promoting complex subunit 15 isoform a

    See identical proteins and their annotated locations for NP_001265414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 2, and 23-28 all encode the same isoform (a).
    Source sequence(s)
    AF077206, BG752082
    Consensus CDS
    CCDS60880.1
    UniProtKB/Swiss-Prot
    P60006
    Related
    ENSP00000443645.1, ENST00000545680.5
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  2. NM_001278486.2NP_001265415.1  anaphase-promoting complex subunit 15 isoform a

    See identical proteins and their annotated locations for NP_001265415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes isoform a. Variants 1, 2, and 23-28 all encode the same isoform (a).
    Source sequence(s)
    AK222622, AP000812
    Consensus CDS
    CCDS60880.1
    UniProtKB/Swiss-Prot
    P60006
    Related
    ENSP00000439403.1, ENST00000543587.5
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  3. NM_001278487.2NP_001265416.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AF077206, AP000812, BG764016
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Related
    ENSP00000440002.1, ENST00000538393.5
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  4. NM_001278488.2NP_001265417.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AF077206, AP000812, BU532056
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Related
    ENSP00000443383.1, ENST00000535503.5
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  5. NM_001278489.2NP_001265418.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AF077206, CN306434
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Related
    ENSP00000446412.1, ENST00000535234.5
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  6. NM_001278490.2NP_001265419.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265419.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AF077206, BU930156
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Related
    ENSP00000446383.1, ENST00000545944.5
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  7. NM_001278491.1NP_001265420.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AF077206, AP000812, BE616852
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  8. NM_001278492.2NP_001265421.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Related
    ENSP00000443911.1, ENST00000542531.5
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  9. NM_001278493.2NP_001265422.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  10. NM_001278494.2NP_001265423.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265423.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Related
    ENSP00000440983.1, ENST00000538919.5
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  11. NM_001330321.2NP_001317250.1  anaphase-promoting complex subunit 15 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) uses an alternate 3' terminal exon compared to variant 1. It encodes isoform c, which is longer than and has a distinct C-terminus compared to isoform a. Variants 12-17 all encode the same isoform (c).
    Source sequence(s)
    AP000812, HY166245
    Consensus CDS
    CCDS81593.1
    UniProtKB/TrEMBL
    G5EA39
    Related
    ENSP00000437360.1, ENST00000543050.5
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  12. NM_001393427.1NP_001380356.1  anaphase-promoting complex subunit 15 isoform c

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  13. NM_001393428.1NP_001380357.1  anaphase-promoting complex subunit 15 isoform c

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  14. NM_001393429.1NP_001380358.1  anaphase-promoting complex subunit 15 isoform c

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  15. NM_001393430.1NP_001380359.1  anaphase-promoting complex subunit 15 isoform c

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  16. NM_001393431.1NP_001380360.1  anaphase-promoting complex subunit 15 isoform c

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  17. NM_001393432.1NP_001380361.1  anaphase-promoting complex subunit 15 isoform d

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:460
    ANAPC15; Anaphase-promoting complex subunit 15
  18. NM_001393433.1NP_001380362.1  anaphase-promoting complex subunit 15 isoform d

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:460
    ANAPC15; Anaphase-promoting complex subunit 15
  19. NM_001393434.1NP_001380363.1  anaphase-promoting complex subunit 15 isoform d

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:460
    ANAPC15; Anaphase-promoting complex subunit 15
  20. NM_001393435.1NP_001380364.1  anaphase-promoting complex subunit 15 isoform d

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:460
    ANAPC15; Anaphase-promoting complex subunit 15
  21. NM_001393436.1NP_001380365.1  anaphase-promoting complex subunit 15 isoform d

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Related
    ENSP00000437683.1, ENST00000537644.5
    Conserved Domains (1) summary
    pfam15243
    Location:460
    ANAPC15; Anaphase-promoting complex subunit 15
  22. NM_001393437.1NP_001380366.1  anaphase-promoting complex subunit 15 isoform a

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  23. NM_001393438.1NP_001380367.1  anaphase-promoting complex subunit 15 isoform a

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  24. NM_001393439.1NP_001380368.1  anaphase-promoting complex subunit 15 isoform a

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  25. NM_001393440.1NP_001380369.1  anaphase-promoting complex subunit 15 isoform a

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  26. NM_001393441.1NP_001380370.1  anaphase-promoting complex subunit 15 isoform a

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  27. NM_001393442.1NP_001380371.1  anaphase-promoting complex subunit 15 isoform a

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  28. NM_001393443.1NP_001380372.1  anaphase-promoting complex subunit 15 isoform e

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  29. NM_001393444.1NP_001380373.1  anaphase-promoting complex subunit 15 isoform e

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  30. NM_001393445.1NP_001380374.1  anaphase-promoting complex subunit 15 isoform e

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  31. NM_001393446.1NP_001380375.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  32. NM_001393447.1NP_001380376.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  33. NM_001393448.1NP_001380377.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  34. NM_001393449.1NP_001380378.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  35. NM_001393450.1NP_001380379.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  36. NM_001393451.1NP_001380380.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  37. NM_001393452.1NP_001380381.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  38. NM_001393453.1NP_001380382.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  39. NM_001393454.1NP_001380383.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  40. NM_001393455.1NP_001380384.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  41. NM_001393456.1NP_001380385.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  42. NM_001393457.1NP_001380386.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  43. NM_001393458.1NP_001380387.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15
  44. NM_001393459.1NP_001380388.1  anaphase-promoting complex subunit 15 isoform f

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Related
    ENSP00000441774.1, ENST00000502597.2
  45. NM_014042.3NP_054761.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_054761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AF077206
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Related
    ENSP00000227618.4, ENST00000227618.8
    Conserved Domains (1) summary
    pfam15243
    Location:462
    ANAPC15; Anaphase-promoting complex subunit 15

RNA

  1. NR_171684.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000812
  2. NR_171685.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000812
  3. NR_171686.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000812
  4. NR_171687.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000812

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    72106372..72112780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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