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ANAPC15 anaphase promoting complex subunit 15 [ Homo sapiens (human) ]

Gene ID: 25906, updated on 7-Jun-2020

Summary

Official Symbol
ANAPC15provided by HGNC
Official Full Name
anaphase promoting complex subunit 15provided by HGNC
Primary source
HGNC:HGNC:24531
See related
Ensembl:ENSG00000110200 MIM:614717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC15; HSPC020; C11orf51
Expression
Ubiquitous expression in bone marrow (RPKM 6.8), testis (RPKM 5.8) and 25 other tissues See more
Orthologs

Genomic context

See ANAPC15 in Genome Data Viewer
Location:
11q13.4
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (72106372..72112776, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71820633..71823822, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene microRNA 3165 Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 6 Neighboring gene folate receptor gamma

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564M082

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
regulation of mitotic cell cycle spindle assembly checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic cell cycle spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intracellular IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
anaphase-promoting complex subunit 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278485.2NP_001265414.1  anaphase-promoting complex subunit 15 isoform a

    See identical proteins and their annotated locations for NP_001265414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AF077206, BG752082
    Consensus CDS
    CCDS60880.1
    UniProtKB/Swiss-Prot
    P60006
    Related
    ENSP00000443645.1, ENST00000545680.5
    Conserved Domains (1) summary
    pfam15243
    Location:362
    ANAPC15; Anaphase-promoting complex subunit 15
  2. NM_001278486.2NP_001265415.1  anaphase-promoting complex subunit 15 isoform a

    See identical proteins and their annotated locations for NP_001265415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK222622, AP000812
    Consensus CDS
    CCDS60880.1
    UniProtKB/Swiss-Prot
    P60006
    Related
    ENSP00000439403.1, ENST00000543587.5
    Conserved Domains (1) summary
    pfam15243
    Location:362
    ANAPC15; Anaphase-promoting complex subunit 15
  3. NM_001278487.2NP_001265416.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR andz uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF077206, AP000812, BG764016
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Related
    ENSP00000440002.1, ENST00000538393.5
    Conserved Domains (1) summary
    pfam15243
    Location:362
    ANAPC15; Anaphase-promoting complex subunit 15
  4. NM_001278488.1NP_001265417.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR andz uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF077206, BU532056
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Related
    ENSP00000443383.1, ENST00000535503.5
    Conserved Domains (1) summary
    pfam15243
    Location:362
    ANAPC15; Anaphase-promoting complex subunit 15
  5. NM_001278489.2NP_001265418.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR andz uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF077206, CN306434
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Related
    ENSP00000446412.1, ENST00000535234.5
    Conserved Domains (1) summary
    pfam15243
    Location:362
    ANAPC15; Anaphase-promoting complex subunit 15
  6. NM_001278490.2NP_001265419.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265419.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR andz uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF077206, BU930156
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Related
    ENSP00000446383.1, ENST00000545944.5
    Conserved Domains (1) summary
    pfam15243
    Location:362
    ANAPC15; Anaphase-promoting complex subunit 15
  7. NM_001278491.1NP_001265420.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR andz uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF077206, AP000812, BE616852
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Conserved Domains (1) summary
    pfam15243
    Location:362
    ANAPC15; Anaphase-promoting complex subunit 15
  8. NM_001278492.1NP_001265421.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR andz uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF077206, AP000812, BU856100
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Related
    ENSP00000443911.1, ENST00000542531.5
    Conserved Domains (1) summary
    pfam15243
    Location:362
    ANAPC15; Anaphase-promoting complex subunit 15
  9. NM_001278493.1NP_001265422.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR andz uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF077206, AP000812, HY080534
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Conserved Domains (1) summary
    pfam15243
    Location:362
    ANAPC15; Anaphase-promoting complex subunit 15
  10. NM_001278494.1NP_001265423.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265423.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR andz uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF077206, AP000812, CD049337
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Related
    ENSP00000440983.1, ENST00000538919.5
    Conserved Domains (1) summary
    pfam15243
    Location:362
    ANAPC15; Anaphase-promoting complex subunit 15
  11. NM_001330321.2NP_001317250.1  anaphase-promoting complex subunit 15 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) uses an alternate 3' terminal exon compared to variant 1. It encodes isoform c, which is longer than and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AP000812, HY166245
    Consensus CDS
    CCDS81593.1
    UniProtKB/TrEMBL
    G5EA39
    Related
    ENSP00000437360.1, ENST00000543050.5
    Conserved Domains (1) summary
    pfam15243
    Location:261
    ANAPC15; Anaphase-promoting complex subunit 15
  12. NM_014042.3NP_054761.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_054761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF077206
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Related
    ENSP00000227618.4, ENST00000227618.8
    Conserved Domains (1) summary
    pfam15243
    Location:362
    ANAPC15; Anaphase-promoting complex subunit 15

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    72106372..72112776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017497.1XP_016872986.1  anaphase-promoting complex subunit 15 isoform X1

    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Conserved Domains (1) summary
    pfam15243
    Location:362
    ANAPC15; Anaphase-promoting complex subunit 15
  2. XM_017017496.1XP_016872985.1  anaphase-promoting complex subunit 15 isoform X1

    UniProtKB/Swiss-Prot
    P60006
    UniProtKB/TrEMBL
    A0A024R5G0
    Conserved Domains (1) summary
    pfam15243
    Location:362
    ANAPC15; Anaphase-promoting complex subunit 15
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