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AMBP alpha-1-microglobulin/bikunin precursor [ Homo sapiens (human) ]

Gene ID: 259, updated on 3-Jun-2018
Official Symbol
AMBPprovided by HGNC
Official Full Name
alpha-1-microglobulin/bikunin precursorprovided by HGNC
Primary source
HGNC:HGNC:453
See related
Ensembl:ENSG00000106927 MIM:176870; Vega:OTTHUMG00000020534
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC
Summary
This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 2536.6) See more
Orthologs
See AMBP in Genome Data Viewer
Location:
9q32
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (114060127..114078472, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116822407..116840752, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene programmed cell death 2 pseudogene Neighboring gene zinc finger protein 618 Neighboring gene VISTA enhancer hs641 Neighboring gene uncharacterized LOC107987120 Neighboring gene kinesin family member 12

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
    Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
  • Scavenging of heme from plasma, organism-specific biosystem (from REACTOME)
    Scavenging of heme from plasma, organism-specific biosystemFree heme is damaging to tissues as it intercalates into biologic membranes, perturbing lipid bilayers and promoting the conversion of low-density lipoprotein to cytotoxic oxidized products. Moreover...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
IgA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
IgA binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium channel inhibitor activity NAS
Non-traceable Author Statement
more info
PubMed 
calcium oxalate binding NAS
Non-traceable Author Statement
more info
PubMed 
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
female pregnancy NAS
Non-traceable Author Statement
more info
PubMed 
heme catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of JNK cascade TAS
Traceable Author Statement
more info
PubMed 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of immune response NAS
Non-traceable Author Statement
more info
PubMed 
protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein-chromophore linkage IEA
Inferred from Electronic Annotation
more info
 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein AMBP
Names
bikunin
complex-forming glycoprotein heterogeneous in charge
growth-inhibiting protein 19
inter-alpha-trypsin inhibitor light chain
protein HC
trypstatin
uristatin
uronic-acid-rich protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001633.3NP_001624.1  protein AMBP preproprotein

    See identical proteins and their annotated locations for NP_001624.1

    Status: REVIEWED

    Source sequence(s)
    BC041593, CB141734
    Consensus CDS
    CCDS6800.1
    UniProtKB/Swiss-Prot
    P02760
    Related
    ENSP00000265132.3, OTTHUMP00000021967, ENST00000265132.7, OTTHUMT00000053758
    Conserved Domains (4) summary
    cd00109
    Location:229282
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:286338
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00061
    Location:42186
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    cl21528
    Location:2248
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    114060127..114078472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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