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DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 [ Homo sapiens (human) ]

Gene ID: 25822, updated on 10-Dec-2019

Summary

Official Symbol
DNAJB5provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member B5provided by HGNC
Primary source
HGNC:HGNC:14887
See related
Ensembl:ENSG00000137094 MIM:611328
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Hsc40
Summary
This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in other DNAJ family members. In mice, a multi-protein complex containing this protein, thioredoxin 1, and histone deacetylase 4, serves as a master negative regulator of cardiac hypertrophy. [provided by RefSeq, Mar 2017]
Expression
Broad expression in heart (RPKM 17.5), brain (RPKM 13.1) and 21 other tissues See more
Orthologs

Genomic context

See DNAJB5 in Genome Data Viewer
Location:
9p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (34989369..34998900)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34989638..34998430)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene PHD finger protein 24 Neighboring gene glutamate-ammonia ligase pseudogene 4 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta pseudogene 6 Neighboring gene Sharpr-MPRA regulatory region 8519 Neighboring gene DNAJB5 divergent transcript Neighboring gene SPATA31 subfamily D member 1 pseudogene Neighboring gene SYF2 pre-mRNA splicing factor pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to unfolded protein IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily B member 5
Names
DnaJ (Hsp40) homolog, subfamily B, member 5
heat shock cognate 40
heat shock protein Hsp40-2
heat shock protein Hsp40-3
heat shock protein cognate 40

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053054.1 RefSeqGene

    Range
    5273..14065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135004.3NP_001128476.3  dnaJ homolog subfamily B member 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 6 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AL355377
    Consensus CDS
    CCDS47960.2
    Related
    ENSP00000404079.3, ENST00000453597.7
  2. NM_001135005.3NP_001128477.1  dnaJ homolog subfamily B member 5 isoform 1

    See identical proteins and their annotated locations for NP_001128477.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA434108, AK023253, AK299647, AL355377
    Consensus CDS
    CCDS47959.1
    UniProtKB/Swiss-Prot
    O75953
    Related
    ENSP00000413684.2, ENST00000454002.6
    Conserved Domains (1) summary
    COG0484
    Location:72415
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  3. NM_001349723.2NP_001336652.1  dnaJ homolog subfamily B member 5 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Both variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AI122943, AL355377
    Consensus CDS
    CCDS47959.1
    Conserved Domains (1) summary
    COG0484
    Location:72415
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  4. NM_001349724.2NP_001336653.1  dnaJ homolog subfamily B member 5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate translation initiation codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Both variants 3 and 5 encode the same isoform (3).
    Source sequence(s)
    AI122943, AL355377
    Consensus CDS
    CCDS35007.1
    Related
    ENSP00000441999.1, ENST00000545841.5
    Conserved Domains (1) summary
    COG0484
    Location:1343
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  5. NM_001349725.2NP_001336654.2  dnaJ homolog subfamily B member 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 6 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AL355377
  6. NM_012266.6NP_036398.3  dnaJ homolog subfamily B member 5 isoform 3

    See identical proteins and their annotated locations for NP_036398.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation initiation codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Both variants 3 and 5 encode the same isoform (3).
    Source sequence(s)
    AA434108, AK023253, AK314671, AL355377
    Consensus CDS
    CCDS35007.1
    UniProtKB/Swiss-Prot
    O75953
    Related
    ENSP00000312517.5, ENST00000312316.9
    Conserved Domains (1) summary
    COG0484
    Location:1343
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    34989369..34998900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251428.3XP_005251485.1  dnaJ homolog subfamily B member 5 isoform X1

    See identical proteins and their annotated locations for XP_005251485.1

    UniProtKB/Swiss-Prot
    O75953
    Conserved Domains (1) summary
    COG0484
    Location:1343
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
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