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PGLS 6-phosphogluconolactonase [ Homo sapiens (human) ]

Gene ID: 25796, updated on 4-Jul-2021

Summary

Official Symbol
PGLSprovided by HGNC
Official Full Name
6-phosphogluconolactonaseprovided by HGNC
Primary source
HGNC:HGNC:8903
See related
Ensembl:ENSG00000130313 MIM:604951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
6PGL; HEL-S-304
Expression
Ubiquitous expression in spleen (RPKM 10.2), colon (RPKM 9.1) and 25 other tissues See more
Orthologs
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Genomic context

See PGLS in Genome Data Viewer
Location:
19p13.11
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (17511649..17521291)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17622458..17632097)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene nucleoredoxin like 1 Neighboring gene solute carrier family 27 member 1 Neighboring gene PGLS divergent transcript Neighboring gene niban apoptosis regulator 3 Neighboring gene collagen beta(1-O)galactosyltransferase 1 Neighboring gene Sharpr-MPRA regulatory region 8704

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 6-phosphogluconolactonase activity EXP
Inferred from Experiment
more info
PubMed 
enables 6-phosphogluconolactonase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 6-phosphogluconolactonase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pentose-phosphate shunt TAS
Traceable Author Statement
more info
 
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
6-phosphogluconolactonase
Names
epididymis secretory protein Li 304
epididymis secretory sperm binding protein
NP_036220.1
XP_011526199.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012088.3NP_036220.1  6-phosphogluconolactonase

    See identical proteins and their annotated locations for NP_036220.1

    Status: VALIDATED

    Source sequence(s)
    AJ243972, BG764228
    Consensus CDS
    CCDS12361.1
    UniProtKB/Swiss-Prot
    O95336
    UniProtKB/TrEMBL
    A0A0K0K1K7
    Related
    ENSP00000252603.1, ENST00000252603.7
    Conserved Domains (1) summary
    TIGR01198
    Location:11248
    pgl; 6-phosphogluconolactonase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    17511649..17521291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527897.3XP_011526199.1  6-phosphogluconolactonase isoform X1

    Conserved Domains (1) summary
    cd01400
    Location:10152
    6PGL; 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard ...
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