U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acsf3 acyl-CoA synthetase family member 3 [ Mus musculus (house mouse) ]

Gene ID: 257633, updated on 9-May-2024

Summary

Official Symbol
Acsf3provided by MGI
Official Full Name
acyl-CoA synthetase family member 3provided by MGI
Primary source
MGI:MGI:2182591
See related
Ensembl:ENSMUSG00000015016 AllianceGenome:MGI:2182591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable malonyl-CoA synthetase activity and very long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid biosynthetic process and malonate catabolic process. Predicted to act upstream of or within lipid metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined malonic and methylmalonic acidemia. Orthologous to human ACSF3 (acyl-CoA synthetase family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 25.7), adrenal adult (RPKM 17.5) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Acsf3 in Genome Data Viewer
Location:
8 E1; 8 71.97 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123502209..123544626)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122775470..122817887)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530010L16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:125299226-125299409 Neighboring gene predicted gene, 39271 Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene cadherin 15

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC37904

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables acid-thiol ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables malonyl-CoA synthetase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables very long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables very long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in malonate catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
malonate--CoA ligase ACSF3, mitochondrial
Names
acyl-CoA synthetase family member 3, mitochondrial
NP_659181.2
XP_006531093.1
XP_006531095.1
XP_030099428.1
XP_030099430.1
XP_036009945.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144932.4NP_659181.2  malonate--CoA ligase ACSF3, mitochondrial precursor

    See identical proteins and their annotated locations for NP_659181.2

    Status: VALIDATED

    Source sequence(s)
    AA104822, AK141579, AK144352, BI135241, BQ177632
    Consensus CDS
    CCDS40505.1
    UniProtKB/Swiss-Prot
    Q3URE1, Q78IW2, Q8VC75
    UniProtKB/TrEMBL
    A0A1D5RMC8
    Related
    ENSMUSP00000015160.6, ENSMUST00000015160.6
    Conserved Domains (1) summary
    cd05941
    Location:55569
    MCS; Malonyl-CoA synthetase (MCS)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123502209..123544626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243568.1XP_030099428.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q3URE1, Q78IW2, Q8VC75
    UniProtKB/TrEMBL
    A0A1D5RMC8
    Conserved Domains (1) summary
    cd05941
    Location:55569
    MCS; Malonyl-CoA synthetase (MCS)
  2. XM_006531030.3XP_006531093.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006531093.1

    UniProtKB/Swiss-Prot
    Q3URE1, Q78IW2, Q8VC75
    UniProtKB/TrEMBL
    A0A1D5RMC8
    Related
    ENSMUSP00000148762.2, ENSMUST00000212790.2
    Conserved Domains (1) summary
    cd05941
    Location:55569
    MCS; Malonyl-CoA synthetase (MCS)
  3. XM_006531032.4XP_006531095.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006531095.1

    UniProtKB/Swiss-Prot
    Q3URE1, Q78IW2, Q8VC75
    UniProtKB/TrEMBL
    A0A1D5RMC8
    Related
    ENSMUSP00000148725.2, ENSMUST00000212781.2
    Conserved Domains (1) summary
    cd05941
    Location:55569
    MCS; Malonyl-CoA synthetase (MCS)
  4. XM_036154052.1XP_036009945.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q3URE1, Q78IW2, Q8VC75
    UniProtKB/TrEMBL
    A0A1D5RMC8
    Conserved Domains (1) summary
    cd05941
    Location:55569
    MCS; Malonyl-CoA synthetase (MCS)
  5. XM_030243570.1XP_030099430.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q3URE1, Q78IW2, Q8VC75
    UniProtKB/TrEMBL
    A0A1D5RMC8
    Conserved Domains (1) summary
    cd05941
    Location:55569
    MCS; Malonyl-CoA synthetase (MCS)

RNA

  1. XR_003947284.1 RNA Sequence

  2. XR_003947283.1 RNA Sequence