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H2AP H2A.P histone [ Homo sapiens (human) ]

Gene ID: 25763, updated on 5-Aug-2022

Summary

Official Symbol
H2APprovided by HGNC
Official Full Name
H2A.P histoneprovided by HGNC
Primary source
HGNC:HGNC:18417
See related
Ensembl:ENSG00000187516 AllianceGenome:HGNC:18417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HYPM; HIP17; CXorf27
Summary
This gene encodes a protein shown to interact with huntingtin, which contains an expanded polyglutamine tract in individuals with Huntington's disease (PMID: 9700202). [provided by RefSeq, Aug 2011]
Orthologs
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Genomic context

See H2AP in Genome Data Viewer
Location:
Xp11.4
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (37990779..37991314)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (37394369..37394904)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (37850032..37850567)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 49, pseudogene Neighboring gene synaptotagmin like 5 Neighboring gene sterol-C4-methyl oxidase pseudogene Neighboring gene H2A.L variant histone 3 Neighboring gene microRNA 548aj-2

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
huntingtin-interacting protein M
Names
histone H2A.P
huntingtin interacting protein M
huntingtin yeast partner M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021354.1 RefSeqGene

    Range
    4963..5498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012274.2NP_036406.1  huntingtin-interacting protein M

    See identical proteins and their annotated locations for NP_036406.1

    Status: VALIDATED

    Source sequence(s)
    AF049615, AL121578, AW291697
    Consensus CDS
    CCDS43929.1
    UniProtKB/Swiss-Prot
    A1A4D3, O75409
    Related
    ENSP00000339511.3, ENST00000341016.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    37990779..37991314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    37394369..37394904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)