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NUTM1 NUT midline carcinoma family member 1 [ Homo sapiens (human) ]

Gene ID: 256646, updated on 30-Oct-2022

Summary

Official Symbol
NUTM1provided by HGNC
Official Full Name
NUT midline carcinoma family member 1provided by HGNC
Primary source
HGNC:HGNC:29919
See related
Ensembl:ENSG00000184507 MIM:608963; AllianceGenome:HGNC:29919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NUT; FAM22H; C15orf55
Summary
Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 8.8) See more
Orthologs
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Genomic context

See NUTM1 in Genome Data Viewer
Location:
15q14
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (34343315..34357735)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (32141620..32158194)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34635516..34649936)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 6 Neighboring gene uncharacterized LOC124903461 Neighboring gene NOP10 ribonucleoprotein Neighboring gene lysophosphatidylcholine acyltransferase 4 Neighboring gene actin gamma 1 pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC138683, MGC138684, DKFZp434O192

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NUT family member 1
Names
NAP1L4/NUTM1D fusion
NAP1L4/NUTM1D fusion protein
nuclear protein in testis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284292.2NP_001271221.2  NUT family member 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC021822, AC025678
    Consensus CDS
    CCDS61585.1
    Related
    ENSP00000444896.1, ENST00000537011.6
    Conserved Domains (1) summary
    pfam12881
    Location:42608
    NUT; NUT protein
  2. NM_001284293.2NP_001271222.2  NUT family member 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC021822, AC025678
    Consensus CDS
    CCDS61584.1
    Related
    ENSP00000407031.3, ENST00000438749.7
    Conserved Domains (1) summary
    pfam12881
    Location:32592
    NUT; NUT protein
  3. NM_175741.3NP_786883.2  NUT family member 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC021822, AC025678
    Consensus CDS
    CCDS32190.1
    UniProtKB/Swiss-Prot
    Q9NTB3
    Related
    ENSP00000478903.1, ENST00000614490.4
    Conserved Domains (1) summary
    pfam12881
    Location:14574
    NUT; NUT protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    34343315..34357735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432341.1XP_047288297.1  NUT family member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NTB3

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791798.1 Reference GRCh38.p14 PATCHES

    Range
    82056..98561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    32141620..32158194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)