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STEAP1B STEAP family member 1B [ Homo sapiens (human) ]

Gene ID: 256227, updated on 26-Oct-2022

Summary

Official Symbol
STEAP1Bprovided by HGNC
Official Full Name
STEAP family member 1Bprovided by HGNC
Primary source
HGNC:HGNC:41907
See related
Ensembl:ENSG00000105889 AllianceGenome:HGNC:41907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. Predicted to be active in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in prostate (RPKM 3.5), appendix (RPKM 1.8) and 15 other tissues See more
Orthologs
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Genomic context

See STEAP1B in Genome Data Viewer
Location:
7p15.3
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (22419444..22500188, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (22555533..22636076, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (22459063..22539807, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor 5 Neighboring gene RNA, 5S ribosomal pseudogene 227 Neighboring gene HNF4 motif-containing MPRA enhancer 142 Neighboring gene GATA motif-containing MPRA enhancer 55/56 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 6 Neighboring gene STEAP1B antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC87042

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
STEAP family member 1B
Names
STEAP family protein MGC87042

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164460.2NP_001157932.1  STEAP family member 1B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC002480, AC099759, AK308991
    Consensus CDS
    CCDS56469.1
    UniProtKB/Swiss-Prot
    Q6NZ63
    Related
    ENSP00000384370.4, ENST00000404369.8
    Conserved Domains (1) summary
    pfam01794
    Location:121241
    Ferric_reduct; Ferric reductase like transmembrane component
  2. NM_001382447.1NP_001369376.1  STEAP family member 1B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC002480, AC005061, AC099759
    Consensus CDS
    CCDS94065.1
    UniProtKB/TrEMBL
    A0A7I2V339
    Related
    ENSP00000503251.1, ENST00000678116.1
    Conserved Domains (1) summary
    pfam01794
    Location:121241
    Ferric_reduct; Ferric reductase like transmembrane component
  3. NM_207342.3NP_997225.1  STEAP family member 1B isoform 2

    See identical proteins and their annotated locations for NP_997225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and an alternate 3' exon with a distinct 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) lacks an internal segment near the N-terminus and has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC002480, AC005061, AC099759
    Consensus CDS
    CCDS55094.1
    UniProtKB/Swiss-Prot
    B5MCI2, Q6NZ63
    Related
    ENSP00000385239.2, ENST00000406890.6
    Conserved Domains (1) summary
    pfam01794
    Location:102222
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    22419444..22500188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420109.1XP_047276065.1  STEAP family member 1B isoform X5

  2. XM_047420107.1XP_047276063.1  STEAP family member 1B isoform X3

  3. XM_047420103.1XP_047276059.1  STEAP family member 1B isoform X1

  4. XM_047420104.1XP_047276060.1  STEAP family member 1B isoform X1

  5. XM_047420108.1XP_047276064.1  STEAP family member 1B isoform X4

    Related
    ENSP00000416608.1, ENST00000424363.5
  6. XM_047420111.1XP_047276067.1  STEAP family member 1B isoform X7

  7. XM_047420110.1XP_047276066.1  STEAP family member 1B isoform X6

  8. XM_047420106.1XP_047276062.1  STEAP family member 1B isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    22555533..22636076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)