Format

Send to:

Choose Destination

Notch1 notch 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25496, updated on 9-Sep-2018

Summary

Official Symbol
Notch1provided by RGD
Official Full Name
notch 1provided by RGD
Primary source
RGD:3187
See related
Ensembl:ENSRNOG00000019322
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
TAN1; NOTCH
Summary
transmembrane receptor; involved in cell-cell interactions important for development and pattern formation [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 153.0), Heart (RPKM 89.0) and 9 other tissues See more
Orthologs

Genomic context

See Notch1 in Genome Data Viewer
Location:
3p13
Exon count:
34
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (3905562..3951015, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (9266663..9311575, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-5-phosphatase E Neighboring gene SEC16 homolog A, endoplasmic reticulum export factor Neighboring gene uncharacterized LOC103691754 Neighboring gene uncharacterized LOC108350341

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
Notch binding IEA
Inferred from Electronic Annotation
more info
 
Notch binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
 
chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enzyme inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Notch signaling involved in heart development ISO
Inferred from Sequence Orthology
more info
 
Notch signaling involved in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation IEA
Inferred from Electronic Annotation
more info
 
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation ISO
Inferred from Sequence Orthology
more info
 
animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
aortic valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
aortic valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
apoptotic process involved in embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process involved in embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
arterial endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
arterial endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
astrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
atrioventricular node development IEA
Inferred from Electronic Annotation
more info
 
atrioventricular node development ISO
Inferred from Sequence Orthology
more info
 
atrioventricular valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
auditory receptor cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
auditory receptor cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
axonogenesis IEA
Inferred from Electronic Annotation
more info
 
axonogenesis ISO
Inferred from Sequence Orthology
more info
 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
branching morphogenesis of an epithelial tube IEA
Inferred from Electronic Annotation
more info
 
branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
 
cardiac atrium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac chamber formation ISO
Inferred from Sequence Orthology
more info
 
cardiac epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
cardiac left ventricle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cardiac left ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac right atrium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cardiac right atrium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac right ventricle formation IEA
Inferred from Electronic Annotation
more info
 
cardiac right ventricle formation ISO
Inferred from Sequence Orthology
more info
 
cardiac septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac vascular smooth muscle cell development IEA
Inferred from Electronic Annotation
more info
 
cardiac vascular smooth muscle cell development ISO
Inferred from Sequence Orthology
more info
 
cardiac ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cell differentiation in spinal cord IEP
Inferred from Expression Pattern
more info
PubMed 
cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
cell fate specification IEA
Inferred from Electronic Annotation
more info
 
cell fate specification ISO
Inferred from Sequence Orthology
more info
 
cell migration involved in endocardial cushion formation IEA
Inferred from Electronic Annotation
more info
 
cell migration involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
cellular response to follicle-stimulating hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to follicle-stimulating hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to vascular endothelial growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
collecting duct development IEA
Inferred from Electronic Annotation
more info
 
collecting duct development ISO
Inferred from Sequence Orthology
more info
 
compartment pattern specification IEA
Inferred from Electronic Annotation
more info
 
compartment pattern specification ISO
Inferred from Sequence Orthology
more info
 
coronary artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
coronary artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
coronary sinus valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
coronary sinus valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
coronary vein morphogenesis IEA
Inferred from Electronic Annotation
more info
 
coronary vein morphogenesis ISO
Inferred from Sequence Orthology
more info
 
determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
 
distal tubule development IEA
Inferred from Electronic Annotation
more info
 
distal tubule development ISO
Inferred from Sequence Orthology
more info
 
embryonic hindlimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endocardial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
endocardial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
endocardial cushion development ISO
Inferred from Sequence Orthology
more info
 
endocardial cushion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endocardium development ISO
Inferred from Sequence Orthology
more info
 
endocardium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endocardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endoderm development IEA
Inferred from Electronic Annotation
more info
 
endoderm development ISO
Inferred from Sequence Orthology
more info
 
epidermis development ISO
Inferred from Sequence Orthology
more info
 
epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
epithelial to mesenchymal transition involved in endocardial cushion formation IEA
Inferred from Electronic Annotation
more info
 
epithelial to mesenchymal transition involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
forebrain development ISO
Inferred from Sequence Orthology
more info
 
foregut morphogenesis IEA
Inferred from Electronic Annotation
more info
 
foregut morphogenesis ISO
Inferred from Sequence Orthology
more info
 
glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
glomerular mesangial cell development IEA
Inferred from Electronic Annotation
more info
 
glomerular mesangial cell development ISO
Inferred from Sequence Orthology
more info
 
growth involved in heart morphogenesis IEA
Inferred from Electronic Annotation
more info
 
growth involved in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
heart looping IEA
Inferred from Electronic Annotation
more info
 
heart looping ISO
Inferred from Sequence Orthology
more info
 
heart trabecula morphogenesis ISO
Inferred from Sequence Orthology
more info
 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
 
humoral immune response IEA
Inferred from Electronic Annotation
more info
 
humoral immune response ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
interleukin-4 secretion IEA
Inferred from Electronic Annotation
more info
 
interleukin-4 secretion ISO
Inferred from Sequence Orthology
more info
 
keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
left/right axis specification IEA
Inferred from Electronic Annotation
more info
 
left/right axis specification ISO
Inferred from Sequence Orthology
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
liver development ISO
Inferred from Sequence Orthology
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
lung development ISO
Inferred from Sequence Orthology
more info
 
mesenchymal cell development IEA
Inferred from Electronic Annotation
more info
 
mesenchymal cell development ISO
Inferred from Sequence Orthology
more info
 
mitral valve formation IEA
Inferred from Electronic Annotation
more info
 
mitral valve formation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of anoikis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of biomineral tissue development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of biomineral tissue development NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of calcium ion-dependent exocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cardiac muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of catalytic activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration involved in sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation involved in heart valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation involved in heart valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of extracellular matrix constituent secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extracellular matrix constituent secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of growth rate IEA
Inferred from Electronic Annotation
more info
 
negative regulation of growth rate ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inner ear auditory receptor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inner ear auditory receptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myotube differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of photoreceptor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of photoreceptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of pro-B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of pro-B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
neural tube development IEA
Inferred from Electronic Annotation
more info
 
neural tube development ISO
Inferred from Sequence Orthology
more info
 
neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
neuron fate commitment ISO
Inferred from Sequence Orthology
more info
 
neuronal stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
oligodendrocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
pericardium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
pericardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JAK-STAT cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of aorta morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process involved in morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process involved in morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of astrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cardiac epithelial to mesenchymal transition IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription of Notch receptor target IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription of Notch receptor target ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of viral genome replication IEA
Inferred from Electronic Annotation
more info
 
positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
prostate gland epithelium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
prostate gland epithelium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
pulmonary valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
pulmonary valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of cardioblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of epithelial cell proliferation involved in prostate gland development IEA
Inferred from Electronic Annotation
more info
 
regulation of epithelial cell proliferation involved in prostate gland development ISO
Inferred from Sequence Orthology
more info
 
regulation of extracellular matrix assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of inner ear auditory receptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of somitogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of somitogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
response to corticosteroid IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to muramyl dipeptide IEA
Inferred from Electronic Annotation
more info
 
response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IEA
Inferred from Electronic Annotation
more info
 
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
somatic stem cell division IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell division ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
tissue regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
tube formation ISO
Inferred from Sequence Orthology
more info
 
tube formation ISS
Inferred from Sequence or Structural Similarity
more info
 
vasculogenesis involved in coronary vascular morphogenesis IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis involved in coronary vascular morphogenesis ISO
Inferred from Sequence Orthology
more info
 
venous blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
venous endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
venous endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
ventricular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
ventricular trabecula myocardium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ventricular trabecula myocardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
MAML1-RBP-Jkappa- ICN1 complex IEA
Inferred from Electronic Annotation
more info
 
MAML1-RBP-Jkappa- ICN1 complex ISO
Inferred from Sequence Orthology
more info
 
acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction ISO
Inferred from Sequence Orthology
more info
 
adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
neurogenic locus notch homolog protein 1
Names
Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
Notch gene homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105721.1NP_001099191.1  neurogenic locus notch homolog protein 1 precursor

    See identical proteins and their annotated locations for NP_001099191.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474001
    UniProtKB/Swiss-Prot
    Q07008
    Related
    ENSRNOP00000026212.6, ENSRNOT00000026212.7
    Conserved Domains (11) summary
    smart00004
    Location:14421479
    NL; Domain found in Notch and Lin-12
    cd00054
    Location:869905
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00204
    Location:19122024
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00066
    Location:14871522
    Notch; LNR domain
    pfam03153
    Location:22012417
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06816
    Location:15671618
    NOD; NOTCH protein
    pfam07684
    Location:16621719
    NODP; NOTCH protein
    pfam11235
    Location:23392490
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11936
    Location:24542516
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:19222015
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:18701915
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    3905562..3951015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    4097915..4143369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center