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Notch1 notch receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25496, updated on 27-Feb-2024

Summary

Official Symbol
Notch1provided by RGD
Official Full Name
notch receptor 1provided by RGD
Primary source
RGD:3187
See related
Ensembl:ENSRNOG00000019322 AllianceGenome:RGD:3187
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
TAN1; NOTCH
Summary
Enables transmembrane signaling receptor activity. Involved in several processes, including nervous system development; positive regulation of cell differentiation; and positive regulation of macromolecule metabolic process. Located in several cellular components, including Golgi apparatus; acrosomal vesicle; and nucleus. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 153.0), Heart (RPKM 89.0) and 9 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See Notch1 in Genome Data Viewer
Location:
3p13
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_06 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (9277955..9323531, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (3905562..3951015, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene peptidase, mitochondrial processing subunit alpha Neighboring gene inositol polyphosphate-5-phosphatase E Neighboring gene SEC16 homolog A, endoplasmic reticulum export factor Neighboring gene uncharacterized LOC103691754 Neighboring gene uncharacterized LOC120101512

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables Notch binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription regulator activator activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Notch signaling involved in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in T-helper 17 type immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in aortic valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process involved in embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in arterial endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in astrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in atrioventricular node development ISO
Inferred from Sequence Orthology
more info
 
involved_in atrioventricular valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within auditory receptor cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of calcium-ion regulated exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac atrium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac chamber formation ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac left ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle cell myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac right atrium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac right ventricle formation ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac vascular smooth muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation in spinal cord IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell migration involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to follicle-stimulating hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to vascular endothelial growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in collecting duct development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within compartment pattern specification ISO
Inferred from Sequence Orthology
more info
 
involved_in coronary artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in coronary sinus valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in coronary vein morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
 
involved_in distal tubule development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endocardial cushion development ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardium development ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endoderm development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epidermal cell fate specification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epidermis development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial to mesenchymal transition involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within forebrain development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within foregut morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in glial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in glomerular mesangial cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in growth involved in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart looping ISO
Inferred from Sequence Orthology
more info
 
involved_in heart trabecula morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within humoral immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inhibition of neuroepithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-17-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in left/right axis specification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
 
involved_in luteolysis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mesenchymal cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in mitral valve formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of biomineral tissue development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion molecule production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell proliferation involved in heart valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extracellular matrix constituent secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of inner ear auditory receptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of photoreceptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of pro-B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of pro-B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within neural tube development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neuroendocrine cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in oligodendrocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in pericardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process involved in morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of astrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac epithelial to mesenchymal transition IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuroblast proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription of Notch receptor target IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription of Notch receptor target ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of viral transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostate gland epithelium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in pulmonary valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardioblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell adhesion involved in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of epithelial cell proliferation involved in prostate gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of inner ear auditory receptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of somitogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of retinal cone cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within somatic stem cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in tissue regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in tube formation ISO
Inferred from Sequence Orthology
more info
 
involved_in tube formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vasculogenesis involved in coronary vascular morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within venous blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in venous endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular trabecula myocardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MAML1-RBP-Jkappa- ICN1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
neurogenic locus notch homolog protein 1
Names
Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
Notch gene homolog 1
notch 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105721.1NP_001099191.1  neurogenic locus notch homolog protein 1 precursor

    See identical proteins and their annotated locations for NP_001099191.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474001
    UniProtKB/Swiss-Prot
    F1M9E7, Q07008
    UniProtKB/TrEMBL
    A0A8I6AT84
    Related
    ENSRNOP00000026212.6, ENSRNOT00000026212.8
    Conserved Domains (11) summary
    smart00004
    Location:14421479
    NL; Domain found in Notch and Lin-12
    cd00054
    Location:869905
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00204
    Location:19122024
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00066
    Location:14871522
    Notch; LNR domain
    pfam03153
    Location:22012417
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam06816
    Location:15671618
    NOD; NOTCH protein
    pfam07684
    Location:16621719
    NODP; NOTCH protein
    pfam11235
    Location:23392490
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11936
    Location:24542516
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:19222015
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:18701915
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    29676040..29721613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104374.2XP_038960302.1  neurogenic locus notch homolog protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AT84
    Conserved Domains (11) summary
    smart00004
    Location:12191256
    NL; Domain found in Notch and Lin-12
    COG0666
    Location:16981888
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:646682
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:16471692
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:13091338
    Notch; LNR domain
    pfam03154
    Location:19012270
    Atrophin-1; Atrophin-1 family
    pfam06816
    Location:13441398
    NOD; NOTCH protein
    pfam07684
    Location:14401496
    NODP; NOTCH protein
    pfam11936
    Location:22322293
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:16991792
    Ank_2; Ankyrin repeats (3 copies)
    cd21702
    Location:14871566
    JMTM_Notch1; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins