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MCM9 minichromosome maintenance 9 homologous recombination repair factor [ Homo sapiens (human) ]

Gene ID: 254394, updated on 11-Oct-2020

Summary

Official Symbol
MCM9provided by HGNC
Official Full Name
minichromosome maintenance 9 homologous recombination repair factorprovided by HGNC
Primary source
HGNC:HGNC:21484
See related
Ensembl:ENSG00000111877 MIM:610098
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ODG4; MCMDC1; C6orf61; dJ329L24.1; dJ329L24.3
Summary
The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in thyroid (RPKM 3.1), lymph node (RPKM 3.0) and 25 other tissues See more
Orthologs

Genomic context

See MCM9 in Genome Data Viewer
Location:
6q22.31
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (118813455..118935159, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (119134612..119256327, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene centrosomal protein 85 like Neighboring gene SSX family pseudogene 10 Neighboring gene selenoprotein K pseudogene 3 Neighboring gene anti-silencing function 1A histone chaperone Neighboring gene family with sequence similarity 184 member A Neighboring gene microRNA 548b Neighboring gene mannosidase alpha class 1A member 1 Neighboring gene ribosomal protein L13a pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13942, FLJ20170, FLJ56845, MGC35304

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA helicase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MutLbeta complex binding IDA
Inferred from Direct Assay
more info
PubMed 
MutSalpha complex binding IDA
Inferred from Direct Assay
more info
PubMed 
MutSbeta complex binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MCM8-MCM9 complex IDA
Inferred from Direct Assay
more info
PubMed 
chromosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA helicase MCM9
Names
DNA replication licensing factor MCM9
mini-chromosome maintenance deficient domain-containing protein 1
minichromosome maintenance complex component 9
NP_001365285.1
NP_001365286.1
NP_001365287.1
NP_001365288.1
NP_001365289.1
NP_001365290.1
NP_001365291.1
NP_001365292.1
NP_001365293.1
NP_001365294.1
NP_001365295.1
NP_001365296.1
NP_001365297.1
NP_001365298.1
NP_001365299.1
NP_001365300.1
NP_001365301.1
NP_060166.2
NP_694987.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041822.1 RefSeqGene

    Range
    8425..126714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001378356.1NP_001365285.1  DNA helicase MCM9 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 4, encodes isoform 1.
    Source sequence(s)
    AL132874, AL359634
    Related
    ENSP00000314505.5, ENST00000316316.10
  2. NM_001378357.1NP_001365286.1  DNA helicase MCM9 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1 and 3, encodes isoform 1.
    Source sequence(s)
    AL132874, AL359634
  3. NM_001378358.1NP_001365287.1  DNA helicase MCM9 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AL132874
  4. NM_001378359.1NP_001365288.1  DNA helicase MCM9 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform 3.
    Source sequence(s)
    AL132874, AL359634
  5. NM_001378360.1NP_001365289.1  DNA helicase MCM9 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform 3.
    Source sequence(s)
    AL132874, AL359634
  6. NM_001378361.1NP_001365290.1  DNA helicase MCM9 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 9 and 10, encodes isoform 4.
    Source sequence(s)
    AL132874
  7. NM_001378362.1NP_001365291.1  DNA helicase MCM9 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 8 and 10, encodes isoform 4.
    Source sequence(s)
    AL132874
  8. NM_001378363.1NP_001365292.1  DNA helicase MCM9 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 8 and 9, encodes isoform 4.
    Source sequence(s)
    AL132874
  9. NM_001378364.1NP_001365293.1  DNA helicase MCM9 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL132874, AL359634
  10. NM_001378365.1NP_001365294.1  DNA helicase MCM9 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL132874, FP885910
  11. NM_001378366.1NP_001365295.1  DNA helicase MCM9 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL132874, AL359634
  12. NM_001378367.1NP_001365296.1  DNA helicase MCM9 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL132874, AL359634
  13. NM_001378368.1NP_001365297.1  DNA helicase MCM9 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL132874
  14. NM_001378369.1NP_001365298.1  DNA helicase MCM9 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL132874
  15. NM_001378370.1NP_001365299.1  DNA helicase MCM9 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL132874
  16. NM_001378371.1NP_001365300.1  DNA helicase MCM9 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL132874
  17. NM_001378372.1NP_001365301.1  DNA helicase MCM9 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL132874
  18. NM_017696.3NP_060166.2  DNA helicase MCM9 isoform 1

    See identical proteins and their annotated locations for NP_060166.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AL132874, AL359634
    Consensus CDS
    CCDS56447.1
    UniProtKB/Swiss-Prot
    Q9NXL9
    Conserved Domains (3) summary
    smart00350
    Location:116603
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:13128
    MCM_N; MCM N-terminal domain
    cl21455
    Location:347483
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  19. NM_153255.5NP_694987.1  DNA helicase MCM9 isoform 2

    See identical proteins and their annotated locations for NP_694987.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate 3' terminal exon and lacks 6 exons in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 2 and 5 both encode the same isoform (2).
    Source sequence(s)
    AL132874
    Consensus CDS
    CCDS5121.1
    UniProtKB/Swiss-Prot
    Q9NXL9
    UniProtKB/TrEMBL
    A0A0S2Z662
    Related
    ENSP00000312870.3, ENST00000316068.7
    Conserved Domains (1) summary
    COG1241
    Location:10385
    Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]

RNA

  1. NR_165493.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132874, AL359634
  2. NR_165494.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132874

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    118813455..118935159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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