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TBC1D28 TBC1 domain family member 28 [ Homo sapiens (human) ]

Gene ID: 254272, updated on 5-Aug-2022

Summary

Official Symbol
TBC1D28provided by HGNC
Official Full Name
TBC1 domain family member 28provided by HGNC
Primary source
HGNC:HGNC:26858
See related
Ensembl:ENSG00000189375 AllianceGenome:HGNC:26858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 3.9) See more
Orthologs
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Genomic context

See TBC1D28 in Genome Data Viewer
Location:
17p11.2
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (18634247..18644391, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (18581077..18591222, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (18537560..18547704, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 144B, pseudogene Neighboring gene uncharacterized LOC107985051 Neighboring gene Sharpr-MPRA regulatory region 6133 Neighboring gene uncharacterized LOC124903945 Neighboring gene PAIP1 pseudogene 2 Neighboring gene zinc finger protein 286B (pseudogene) Neighboring gene forkhead box O3B Neighboring gene ubiquitin conjugating enzyme E2 S pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40244, MGC138217, MGC138221

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
TBC1 domain family member 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039397.3NP_001034486.2  TBC1 domain family member 28

    See identical proteins and their annotated locations for NP_001034486.2

    Status: VALIDATED

    Source sequence(s)
    AC026271
    Consensus CDS
    CCDS42273.1
    UniProtKB/Swiss-Prot
    Q2M2D7, Q2M2E1
    Related
    ENSP00000385821.1, ENST00000405044.7
    Conserved Domains (1) summary
    cl02495
    Location:102182
    RabGAP-TBC; Rab-GTPase-TBC domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    18634247..18644391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024419.3XP_016879908.1  TBC1 domain family member 28 isoform X1

  2. XM_017024423.2XP_016879912.1  TBC1 domain family member 28 isoform X4

  3. XM_017024416.3XP_016879905.1  TBC1 domain family member 28 isoform X1

  4. XM_017024421.3XP_016879910.1  TBC1 domain family member 28 isoform X1

  5. XM_017024417.3XP_016879906.1  TBC1 domain family member 28 isoform X1

  6. XM_017024420.2XP_016879909.1  TBC1 domain family member 28 isoform X1

  7. XM_017024418.3XP_016879907.1  TBC1 domain family member 28 isoform X1

  8. XM_047435718.1XP_047291674.1  TBC1 domain family member 28 isoform X3

  9. XM_017024422.2XP_016879911.1  TBC1 domain family member 28 isoform X2

  10. XM_011523783.4XP_011522085.1  TBC1 domain family member 28 isoform X5

    Conserved Domains (1) summary
    smart00164
    Location:143223
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    18581077..18591222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)