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SFTA3 surfactant associated 3 [ Homo sapiens (human) ]

Gene ID: 253970, updated on 3-May-2025
Official Symbol
SFTA3provided by HGNC
Official Full Name
surfactant associated 3provided by HGNC
Primary source
HGNC:HGNC:18387
See related
Ensembl:ENSG00000257520 MIM:617860; AllianceGenome:HGNC:18387
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPH; SP-H; NANCI; PAHRF; SFTPH
Summary
Involved in wound healing. Located in cytoplasm and extracellular space. [provided by Alliance of Genome Resources, May 2025]
Expression
Restricted expression toward lung (RPKM 71.4) See more
Orthologs
all
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See SFTA3 in Genome Data Viewer
Location:
14q13.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (36473288..36519556, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (30662595..30708840, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (36942493..36988761, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene DPPA3 pseudogene 2 Neighboring gene RNA, U7 small nuclear 93 pseudogene Neighboring gene VISTA enhancer hs1538 Neighboring gene VISTA enhancer hs704 Neighboring gene VISTA enhancer hs1166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:36974689-36975264 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:36977998-36978653 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:36983846-36984473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:36986696-36987694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:36988853-36989852 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:36989853-36990852 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:36990853-36991852 Neighboring gene uncharacterized LOC105370453 Neighboring gene NKX2-1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:36994071-36995009 Neighboring gene NK2 homeobox 1 Neighboring gene phosphorylase kinase regulatory subunit beta pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:37025714-37025870 Neighboring gene ribosomal protein L29 pseudogene 3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. SFTA3 - a novel surfactant protein of the ocular surface and its role in corneal wound healing and tear film surface tension. Schicht M, et al. Sci Rep, 2018 Jun 28. PMID 29955092, Free PMC Article
  2. Expression of recombinant surfactant protein SFTA3 in the human kidney cell line HEK 293T. Schröder H, et al. Ann Anat, 2017 May. PMID 28163207
  3. SFTA3, a novel protein of the lung: three-dimensional structure, characterisation and immune activation. Schicht M, et al. Eur Respir J, 2014 Aug. PMID 24743970
  4. The lncRNA PAHRF functions as a competing endogenous RNA to regulate MST1 expression by sponging miR-23a-3p in pulmonary arterial hypertension. Liu Y, et al. Vascul Pharmacol, 2021 Aug. PMID 34126237
  5. Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. Herriges MJ, et al. Genes Dev, 2014 Jun 15. PMID 24939938, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SFTA3 at the ocular surface seemed to be involved in wound healing and the reduction of surface tension.
    Title: SFTA3 - a novel surfactant protein of the ocular surface and its role in corneal wound healing and tear film surface tension.
  2. In our present work we introduce a technique to synthesize, purify and stabilize recombinant SFTA3 derived from the human embryonic kidney cell line HEK 293T.
    Title: Expression of recombinant surfactant protein SFTA3 in the human kidney cell line HEK 293T.
  3. SFTA3 is an immunoregulatory protein of the lung with relevant protective functions during inflammation at the mucosal sites
    Title: SFTA3, a novel protein of the lung: three-dimensional structure, characterisation and immune activation.
  4. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Markers

Homology

Other Names

  • NKX2.1 associated non-coding intergenic RNA
  • Nkx2.1-associated noncoding intergenic RNA
  • pulmonary arterial hypertension related factor
  • putative protein SFTA3
  • surfactant-associated protein 3
  • surfactant-associated protein H

Clone Names

  • FLJ23494

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated endocytic vesicle TAS
Traceable Author Statement
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellar body TAS
Traceable Author Statement
more info
  

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_138597.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL132857

  2. NR_138598.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL132857

  3. NR_138599.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL132857

  4. NR_138600.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL132857

  5. NR_138601.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL132857

  6. NR_161362.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL132857

  7. NR_161363.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL132857

  8. NR_161364.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL132857

  9. NR_161365.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL132857
    Related
    ENST00000521945.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    36473288..36519556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    30662595..30708840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001101341.1: Suppressed sequence

    Description
    NM_001101341.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  2. NM_001331217.1: Suppressed sequence

    Description
    NM_001331217.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  3. NM_001352986.1: Suppressed sequence

    Description
    NM_001352986.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  4. NM_001352987.1: Suppressed sequence

    Description
    NM_001352987.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C7M3.1 GenPept UniProtKB/Swiss-Prot:P0C7M3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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