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ANGPTL5 angiopoietin like 5 [ Homo sapiens (human) ]

Gene ID: 253935, updated on 11-Jun-2021

Summary

Official Symbol
ANGPTL5provided by HGNC
Official Full Name
angiopoietin like 5provided by HGNC
Primary source
HGNC:HGNC:19705
See related
Ensembl:ENSG00000187151 MIM:607666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in ovary (RPKM 8.8), fat (RPKM 1.3) and 3 other tissues See more
Orthologs
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Genomic context

See ANGPTL5 in Genome Data Viewer
Location:
11q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (101890674..101917050, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (101761405..101787253, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene KIAA1191 pseudogene Neighboring gene plastin 1 pseudogene Neighboring gene centrosomal protein 126 Neighboring gene proline rich 21 pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 535 Neighboring gene cilia and flagella associated protein 300

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
angiopoietin-related protein 5
Names
angiopoietin-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178127.5NP_835228.2  angiopoietin-related protein 5 precursor

    See identical proteins and their annotated locations for NP_835228.2

    Status: VALIDATED

    Source sequence(s)
    AK291523, AP003383, BC049170
    Consensus CDS
    CCDS8312.1
    UniProtKB/Swiss-Prot
    Q86XS5
    Related
    ENSP00000335255.3, ENST00000334289.7
    Conserved Domains (1) summary
    cd00087
    Location:146382
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    101890674..101917050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017466.2XP_016872955.1  angiopoietin-related protein 5 isoform X2

  2. XM_011542735.3XP_011541037.1  angiopoietin-related protein 5 isoform X1

    Conserved Domains (1) summary
    cd00087
    Location:115317
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
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