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spc7 outer kinetochore KNL network protein, KNL-1 family member, blinkin, Spc7 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539155, updated on 18-Sep-2024

Summary

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Official Symbol
spc7
Official Full Name
outer kinetochore KNL network protein, KNL-1 family member, blinkin, Spc7
Primary source
PomBase:SPCC1020.02
Locus tag
SPOM_SPCC1020.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See spc7 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (786289..790660, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase subunit Rpb6 Neighboring gene mitochondrial iron ion transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sos7, an essential component of the conserved Schizosaccharomyces pombe Ndc80-MIND-Spc7 complex, identifies a new family of fungal kinetochore proteins. Jakopec V, et al. Mol Cell Biol, 2012 Aug. PMID 22711988, Free PMC Article
  2. Hierarchical Regulation of Centromeric Cohesion Protection by Meikin and Shugoshin during Meiosis I. Miyazaki S, et al. Cold Spring Harb Symp Quant Biol, 2017. PMID 29196561
  3. MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components. Yamagishi Y, et al. Nat Cell Biol, 2012 Jun 3. PMID 22660415
  4. Meikin-associated polo-like kinase specifies Bub1 distribution in meiosis I. Miyazaki S, et al. Genes Cells, 2017 Jun. PMID 28497540
  5. Generation of a Spindle Checkpoint Arrest from Synthetic Signaling Assemblies. Yuan I, et al. Curr Biol, 2017 Jan 9. PMID 28017606, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit spindle assembly checkpoint proteins and promote chromosome alignment.
    Title: MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components.
  2. Spc7 interacts genetically with the Mal2-containing Sim4 complex.
    Title: The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.
  3. spc7 can suppress the mal3 mutant phenotype. Spc7, an essential component of the kinetochore that associates with the central centromere region, interacts with the microtubule plus-end-associated protein Mal3 at the microtubule-kinetochore interface.
    Title: The fission yeast kinetochore component Spc7 associates with the EB1 family member Mal3 and is required for kinetochore-spindle association.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables kinetochore adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule plus-end binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in deactivation of mitotic spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homologous chromosome orientation in meiotic metaphase I ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in meiotic centromeric cohesion protection in anaphase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid biorientation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid biorientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of meiosis I spindle assembly checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Knl1/Spc105 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of outer kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
outer kinetochore KNL network protein, KNL-1 family member, blinkin, Spc7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    786289..790660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022949.3 → NP_587958.1  outer kinetochore KNL network protein, KNL-1 family member, blinkin, Spc7 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_587958.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O59757
    Conserved Domains (4) summary
    smart00787
    Location:873 → 1189
    Spc7; Spc7 kinetochore protein
    pfam02050
    Location:1042 → 1142
    FliJ; Flagellar FliJ protein
    pfam15402
    Location:102 → 599
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam15577
    Location:1239 → 1300
    Spc7_C2; Spc7_C2
Nucleotide Protein
Heading Accession and Version

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