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Alad aminolevulinate dehydratase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25374, updated on 2-May-2024

Summary

Official Symbol
Aladprovided by RGD
Official Full Name
aminolevulinate dehydrataseprovided by RGD
Primary source
RGD:2083
See related
Ensembl:ENSRNOG00000015206 AllianceGenome:RGD:2083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ALADH; ALADR
Summary
Enables porphobilinogen synthase activity and proteasome core complex binding activity. Involved in several processes, including cellular response to lead ion; response to herbicide; and response to vitamin. Located in cytosol and extracellular space. Used to study anemia and hemochromatosis. Biomarker of acute kidney failure; hypothyroidism; liver cirrhosis; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 448.1), Spleen (RPKM 222.7) and 9 other tissues See more
Orthologs
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Genomic context

See Alad in Genome Data Viewer
Location:
5q24
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (80977562..80987901, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (75961993..75972334, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (78368867..78379206, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene B-box and SPRY domain containing Neighboring gene haloacid dehalogenase-like hydrolase domain containing 3 Neighboring gene similar to human chromosome 9 open reading frame 43 Neighboring gene DNA polymerase epsilon 3, accessory subunit Neighboring gene 60S ribosomal protein L31-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables porphobilinogen synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables porphobilinogen synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables porphobilinogen synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables porphobilinogen synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables porphobilinogen synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables proteasome core complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to interleukin-4 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in heme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme B biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme O biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heme biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to aluminum ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to amino acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to arsenic-containing substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to arsenic-containing substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cadmium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cobalt ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to herbicide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to inorganic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ionizing radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to iron ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to mercury ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to metal ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to methylmercury IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to oxidative stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to platinum ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to selenium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin B1 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin E IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
delta-aminolevulinic acid dehydratase
Names
aminolevulinate, delta-, dehydratase
aminolevulinatedelta-dehydratase
delta - aminolevulinic acid dehydratase
porphobilinogen synthase
NP_037031.1
XP_006238296.1
XP_006238297.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429324.1NP_001416253.1  delta-aminolevulinic acid dehydratase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
  2. NM_001429325.1NP_001416254.1  delta-aminolevulinic acid dehydratase isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
  3. NM_012899.3NP_037031.1  delta-aminolevulinic acid dehydratase isoform 1

    See identical proteins and their annotated locations for NP_037031.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P06214
    UniProtKB/TrEMBL
    A0A8L2R0C7, A6J7V5
    Related
    ENSRNOP00000020625.2, ENSRNOT00000020625.7
    Conserved Domains (1) summary
    cd04824
    Location:8327
    eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    80977562..80987901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238235.3XP_006238297.1  delta-aminolevulinic acid dehydratase isoform X1

    See identical proteins and their annotated locations for XP_006238297.1

    UniProtKB/Swiss-Prot
    P06214
    UniProtKB/TrEMBL
    A0A8L2R0C7, A6J7V5
    Conserved Domains (1) summary
    cd04824
    Location:8327
    eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...
  2. XM_006238234.4XP_006238296.1  delta-aminolevulinic acid dehydratase isoform X1

    UniProtKB/Swiss-Prot
    P06214
    UniProtKB/TrEMBL
    A0A8L2R0C7, A6J7V5
    Conserved Domains (1) summary
    cd04824
    Location:8327
    eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...