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EIF4E1B eukaryotic translation initiation factor 4E family member 1B [ Homo sapiens (human) ]

Gene ID: 253314, updated on 5-Jan-2022

Summary

Official Symbol
EIF4E1Bprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 4E family member 1Bprovided by HGNC
Primary source
HGNC:HGNC:33179
See related
Ensembl:ENSG00000175766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Predicted to be involved in regulation of translation and translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 4F complex and mRNA cap binding activity complex. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See EIF4E1B in Genome Data Viewer
Location:
5q35.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (176630675..176646644)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176057676..176073645)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11151 Neighboring gene synuclein beta Neighboring gene microRNA 4281 Neighboring gene Sharpr-MPRA regulatory region 4950 Neighboring gene VISTA enhancer hs2007 Neighboring gene tetraspanin 17 Neighboring gene long intergenic non-protein coding RNA 1574

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ36951

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mRNA cap binding complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 4E type 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099408.2NP_001092878.1  eukaryotic translation initiation factor 4E type 1B

    See identical proteins and their annotated locations for NP_001092878.1

    Status: VALIDATED

    Source sequence(s)
    AC091934, AK094270, BM709255, DA689940, DR008159, DR731203
    Consensus CDS
    CCDS47345.1
    UniProtKB/Swiss-Prot
    A6NMX2
    Related
    ENSP00000323714.6, ENST00000318682.11
    Conserved Domains (1) summary
    pfam01652
    Location:63222
    IF4E; Eukaryotic initiation factor 4E
  2. NM_001375362.1NP_001362291.1  eukaryotic translation initiation factor 4E type 1B

    Status: VALIDATED

    Source sequence(s)
    AC091934
    Related
    ENSP00000497422.1, ENST00000647833.1
    Conserved Domains (1) summary
    pfam01652
    Location:63222
    IF4E; Eukaryotic initiation factor 4E

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    176630675..176646644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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