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CDY1B chromodomain Y-linked 1B [ Homo sapiens (human) ]

Gene ID: 253175, updated on 2-Nov-2024

Summary

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Official Symbol
CDY1Bprovided by HGNC
Official Full Name
chromodomain Y-linked 1Bprovided by HGNC
Primary source
HGNC:HGNC:23920
See related
Ensembl:ENSG00000172352 AllianceGenome:HGNC:23920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDY
Summary
This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 2.1) See more
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Genomic context

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See CDY1B in Genome Data Viewer
Location:
Yq11.23
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (24044620..24048019, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (24814541..24817940)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (26191376..26194166, complement)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene OFD1 pseudogene 12 Y-linked Neighboring gene elongin C pseudogene 10 Neighboring gene chromodomain Y-linked 17 pseudogene Neighboring gene USP9Y pseudogene 35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Members of the CDY family have different expression patterns: CDY1 transcripts have the best correlation with complete spermatogenesis. Kleiman SE, et al. Hum Genet, 2003 Nov. PMID 14569460
  2. CDY1 analysis in infertile patients with DAZ deletions. Ferlin A, et al. J Endocrinol Invest, 2001 Feb. PMID 11263480
  3. Expression of CDY1 may identify complete spermatogenesis. Kleiman SE, et al. Fertil Steril, 2001 Jan. PMID 11163833
  4. gr/gr-DAZ2-DAZ4-CDY1b deletion is a high-risk factor for male infertility in Tunisian population. Ghorbel M, et al. Gene, 2016 Oct 30. PMID 27457284
  5. The human Y chromosome genes BPY2, CDY1 and DAZ are not essential for sustained fertility. Saut N, et al. Mol Hum Reprod, 2000 Sep. PMID 10956550

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
testis-specific chromodomain protein Y 1
Names
chromodomain protein, Y chromosome, 1, centromeric
chromodomain protein, Y-linked, 1B
testis-specific chromodomain protein on Y, centromeric
NP_001003894.1
NP_001003895.1
XP_011529786.1
XP_054184245.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003894.2 → NP_001003894.1  testis-specific chromodomain protein Y 1 isoform a

    See identical proteins and their annotated locations for NP_001003894.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also called the major transcript, is unspliced. It encodes isoform a.
    Source sequence(s)
    AC068601
    Consensus CDS
    CCDS35487.1
    UniProtKB/Swiss-Prot
    A2RUK1, O14600, Q9Y6F8
    UniProtKB/TrEMBL
    A8K8L0
    Related
    ENSP00000371844.1, ENST00000382407.1
    Conserved Domains (2) summary
    cd06558
    Location:286 → 482
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    smart00298
    Location:5 → 58
    CHROMO; Chromatin organization modifier domain

  2. NM_001003895.1 → NP_001003895.1  testis-specific chromodomain protein Y 1 isoform b

    See identical proteins and their annotated locations for NP_001003895.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also called the minor variant, lacks a segment in the 3' end of the coding sequence, compared to variant 1. Variant 2 encodes isoform b which has a longer and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC068601
    Consensus CDS
    CCDS35486.1
    UniProtKB/TrEMBL
    A8K8F3
    Related
    ENSP00000303178.4, ENST00000306882.4
    Conserved Domains (2) summary
    cd06558
    Location:286 → 482
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    smart00298
    Location:5 → 58
    CHROMO; Chromatin organization modifier domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    24044620..24048019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531484.3 → XP_011529786.1  testis-specific chromodomain protein Y 1 isoform X1

    See identical proteins and their annotated locations for XP_011529786.1

    UniProtKB/TrEMBL
    A8K8L0
    Conserved Domains (2) summary
    cd06558
    Location:286 → 464
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    smart00298
    Location:5 → 58
    CHROMO; Chromatin organization modifier domain

RNA

  1. XR_938655.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    24814541..24817940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328270.1 → XP_054184245.1  testis-specific chromodomain protein Y 1 isoform X1

RNA

  1. XR_008485523.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6F8.1 GenPept UniProtKB/Swiss-Prot:Q9Y6F8

Gene LinkOut

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