Bglap bone gamma-carboxyglutamate protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bglapprovided by RGD
Official Full Name: bone gamma-carboxyglutamate proteinprovided by RGD
Primary source: RGD:2206
See related: Ensembl:ENSRNOG00000019607
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bgp; Bgpr; Bgpra; Bglap2
Summary: highly conserved protein associated with mineralized bone matrix; protein is secreted by calcified tissues and is regulated by vitamin D3 [RGD, Feb 2006]
Expression: Biased expression in Thymus (RPKM 5.0), Spleen (RPKM 2.9) and 9 other tissues See more
Orthologs: human mouse all

Genomic context

Location:: 2q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (187741770..187748445, complement)
104	previous assembly	Rnor_5.0 (GCF_000001895.4)	2	NC_005101.3 (207144494..207150926, complement)

Chromosome 2 - NC_005101.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

These data suggest that Undercarboxylated osteocalcin may have other effects on skeletal muscle in addition to its insulin sensitizing effect.
Title: Hindlimb Immobilization, But Not Castration, Induces Reduction of Undercarboxylated Osteocalcin Associated With Muscle Atrophy in Rats.
Uncarboxylated osteocalcin potentiates insulin secretion, inhibits Kv channels and increases [Ca(2+)]i.
Title: The PLC/PKC/Ras/MEK/Kv channel pathway is involved in uncarboxylated osteocalcin-regulated insulin secretion in rats.
This rat model of complete loss of osteocalcin provides a platform for further understanding the role of osteocalcin in disease.
Title: Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology.
gamma-Carboxylase inhibition prevents osteocalcin carboxylation and protects against diabetic cardiomyopathy, possibly through direct action on upregulated G protein-coupled receptor family C group 6 member A and indirectly via adiponectin.
Title: Effect of gamma-carboxylase inhibition on serum osteocalcin may be partially protective against developing diabetic cardiomyopathy in type 2 diabetic rats.
Bone Gla Protein
Title: Changes of serum osteocalcin, calcium, and potassium in a rat model of type 2 diabetes.
In primary adipocytes, both carboxylated and uncarboxylated osteocalcin increased basal and insulin-stimulated glucose transport.
Title: Carboxylated and uncarboxylated forms of osteocalcin directly modulate the glucose transport system and inflammation in adipocytes.
The physiological changes associated with estrous cycle stage were not sufficient to cause a detectable difference in carboxylated or undercarboxylated osteocalcin concentrations in this study.
Title: Serum concentrations of fully and undercarboxylated osteocalcin do not vary between estrous cycle stages in Sprague-Dawley rats.
Osteocalcin (OC)-containing neurons are distributed throughout the cerebellar nuclei; OC may play a role in modulating the neuroprotective function of osteopontin.
Title: Osteocalcin- and osteopontin-containing neurons in the rat hind brain.
warfarin impaired the carboxylation of osteocalcin in rats. Factor Xa inhibitor edoxaban at or higher doses than needed for an antithrombotic effect sustained the circulating Gla-osteocalcin level.
Title: The effects of warfarin and edoxaban, an oral direct factor Xa inhibitor, on gammacarboxylated (Gla-osteocalcin) and undercarboxylated osteocalcin (uc-osteocalcin) in rats.
results suggest that under some physiological conditions the oncoprotein MDM2 may cooperate with p53 to regulate the osteocalcin gene during osteoblastic differentiation.
Title: p53 and MDM2 are involved in the regulation of osteocalcin gene expression.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Pathways from BioSystems

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Gamma carboxylation, hypusine formation and arylsulfatase activation, organism-specific biosystem (from REACTOME)
Gamma carboxylation, hypusine formation and arylsulfatase activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gamma-carboxylation of protein precursors, organism-specific biosystem (from REACTOME)
Gamma-carboxylation of protein precursors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, organism-specific biosystem (from REACTOME)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Osteoblast, organism-specific biosystem (from WikiPathways)
Osteoblast, organism-specific biosystem
Osteoblast
Post-translational protein modification, organism-specific biosystem (from REACTOME)
Post-translational protein modification, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Removal of aminoterminal propeptides from gamma-carboxylated proteins, organism-specific biosystem (from REACTOME)
Removal of aminoterminal propeptides from gamma-carboxylated proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus, organism-specific biosystem (from REACTOME)
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

RH132274 (e-PCR)
- UniSTS:215557

PMC151127P1 (e-PCR)
- UniSTS:271137

PMC34552P1 (e-PCR)
- UniSTS:273222

PMC34552P2 (e-PCR)
- UniSTS:273223

Homology

Homologs of the Bglap gene: The Bglap gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and mouse.
Orthologs from Annotation Pipeline: 227 organisms have orthologs with human gene Bglap
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
calcium ion binding	ISO Inferred from Sequence Orthology more info
hydroxyapatite binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein homodimerization activity	ISO Inferred from Sequence Orthology more info
structural constituent of bone	IBA Inferred from Biological aspect of Ancestor more info	PubMed
structural constituent of bone	IDA Inferred from Direct Assay more info	PubMed
structural constituent of bone	TAS Traceable Author Statement more info	PubMed
transition metal ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
aging	IEP Inferred from Expression Pattern more info	PubMed
biomineral tissue development	IEA Inferred from Electronic Annotation more info
bone development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
bone development	IEP Inferred from Expression Pattern more info	PubMed
cell aging	IEP Inferred from Expression Pattern more info	PubMed
cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
odontogenesis	IEP Inferred from Expression Pattern more info	PubMed
ossification	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ossification	IEP Inferred from Expression Pattern more info	PubMed
osteoblast development	IEP Inferred from Expression Pattern more info	PubMed
osteoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
osteoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
osteoblast differentiation	ISO Inferred from Sequence Orthology more info
osteoblast differentiation	TAS Traceable Author Statement more info	PubMed
regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
regulation of cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
response to activity	IEP Inferred from Expression Pattern more info	PubMed
response to drug	IEP Inferred from Expression Pattern more info	PubMed
response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
response to gravity	IEP Inferred from Expression Pattern more info	PubMed
response to hydroxyisoflavone	IEP Inferred from Expression Pattern more info	PubMed
response to inorganic substance	IEP Inferred from Expression Pattern more info	PubMed
response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
response to vitamin D	ISO Inferred from Sequence Orthology more info
response to vitamin K	IEP Inferred from Expression Pattern more info	PubMed
response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
cell projection	IDA Inferred from Direct Assay more info	PubMed
collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
dendrite	IDA Inferred from Direct Assay more info	PubMed
extracellular region	IBA Inferred from Biological aspect of Ancestor more info	PubMed
extracellular region	IDA Inferred from Direct Assay more info	PubMed
extracellular region	ISO Inferred from Sequence Orthology more info
extracellular region	TAS Traceable Author Statement more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
perikaryon	IDA Inferred from Direct Assay more info	PubMed
rough endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: osteocalcin

Names: bone Gla-protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin); bone gamma-carboxyglutamate protein 2; bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin); gamma-carboxyglutamic acid-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.