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Bglap bone gamma-carboxyglutamate protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 25295, updated on 5-Mar-2024

Summary

Official Symbol
Bglapprovided by RGD
Official Full Name
bone gamma-carboxyglutamate proteinprovided by RGD
Primary source
RGD:2206
See related
Ensembl:ENSRNOG00000019607 AllianceGenome:RGD:2206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bgp; Bgpr; Bgpra; Bglap2
Summary
A structural constituent of bone. Involved in several processes, including osteoblast development; response to hydroxyisoflavone; and response to vitamin. Located in several cellular components, including Golgi apparatus; perikaryon; and rough endoplasmic reticulum. Used to study congenital hypothyroidism and osteoporosis. Biomarker of autosomal dominant hypocalcemia; end stage renal disease; and polycystic kidney disease. Human ortholog(s) of this gene implicated in osteoarthritis; osteoporosis; prostate cancer; rheumatoid arthritis; and vitamin K deficiency bleeding. Orthologous to human BGLAP (bone gamma-carboxyglutamate protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 5.0), Spleen (RPKM 2.9) and 9 other tissues See more
Orthologs
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Genomic context

See Bglap in Genome Data Viewer
Location:
2q34
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176136341..176137318, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173838518..173839495, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187741770..187748445, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene SMG5 nonsense mediated mRNA decay factor Neighboring gene progestin and adipoQ receptor family member 6 Neighboring gene polyamine-modulated factor 1 Neighboring gene uncharacterized LOC134485637 Neighboring gene solute carrier family 25, member 44

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables hydroxyapatite binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ion binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of bone IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of bone IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of bone ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of bone TAS
Traceable Author Statement
more info
PubMed 
enables transition metal ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in bone development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in bone development IEA
Inferred from Electronic Annotation
more info
 
involved_in bone development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in brain development ISO
Inferred from Sequence Orthology
more info
 
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to vitamin D IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to zinc ion starvation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cognition ISO
Inferred from Sequence Orthology
more info
 
involved_in cognition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of bone development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bone development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ossification IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in osteoblast development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in osteoblast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurotransmitter secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of testosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of testosterone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to gravity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hydroxyisoflavone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to inorganic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to macrophage colony-stimulating factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin D ISO
Inferred from Sequence Orthology
more info
 
involved_in response to vitamin K IEA
Inferred from Electronic Annotation
more info
 
involved_in response to vitamin K IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to zinc ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in stem cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in type B pancreatic cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in type B pancreatic cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
osteocalcin
Names
bone Gla-protein
bone gamma-carboxyglutamate (gla) protein (osteocalcin)
bone gamma-carboxyglutamate protein 2
bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin)
gamma-carboxyglutamic acid-containing protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013414.1NP_038200.1  osteocalcin preproprotein

    See identical proteins and their annotated locations for NP_038200.1

    Status: VALIDATED

    Source sequence(s)
    M25490
    UniProtKB/Swiss-Prot
    P04640
    UniProtKB/TrEMBL
    A0A8I6AK32, A6J671
    Related
    ENSRNOP00000026530.1, ENSRNOT00000026530.4
    Conserved Domains (1) summary
    smart00069
    Location:3195
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    176136341..176137318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)