sav salvador [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: savprovided by FlyBase
Official Full Name: salvadorprovided by FlyBase
Primary source: FLYBASE:FBgn0053193
Locus tag: Dmel_CG33193
See related: AllianceGenome:FB:FBgn0053193
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0172774.152; CG13831; CG13832; CG33193; Dmel\CG33193; Salvador; Salvador/Shar-pei; Sav; SAV; Sav1; SAV1; shar-pei
Summary: Enables molecular adaptor activity. Involved in several processes, including animal organ development; hippo signaling; and regulation of dendrite morphogenesis. Located in apicomedial cortex and cytosol. Colocalizes with cell-cell junction. Is expressed in organism and spermatozoon. Used to study kidney cancer. Orthologous to human SAV1 (salvador family WW domain containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 94D10-94D10; 3-77 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23058609..23061304, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (18884331..18887026, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest Salvador enhances the effects of Hippo kinase activity at multiple points in the Hippo pathway.
Title: Salvador has an extended SARAH domain that mediates binding to Hippo kinase.
In this work, we have explored the disc autonomous function of TGFbeta that promotes wing imaginal disc growth. We have studied the genetic interactions between TGFbeta signaling and other pathways regulating wing disc growth, such as the Insulin and Hippo/Salvador/Warts pathways, as well as cell cycle regulators.
Title: A Search for Genes Mediating the Growth-Promoting Function of TGFβ in the Drosophila melanogaster Wing Disc.
the Salvador-Warts-Hippo pathway has a cell-autonomous function to prevent inappropriate differentiation due to transcription factor imbalance and monitors the intrinsic developmental status of progenitor cells
Title: Salvador-Warts-Hippo pathway in a developmental checkpoint monitoring helix-loop-helix proteins.
Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association
Title: Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association.
Serine-17 is a key residue for the regulation of Sav stability.
Title: A conserved serine residue regulates the stability of Drosophila Salvador and human WW domain-containing adaptor 45 through proteasomal degradation.
The salvador protein pathway restrains tissue growth by phosphorylating and inactivating the oncoprotein Yorkie.
Title: The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway.
The Salvador pathway restrains tissue growth by phosphorylating and inactivating the oncoprotein Yorkie.
Title: Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway.
Data show that brain tumours in l(3)mbt mutants originate from overproliferation of neuroepithelial cells in the optic lobes caused by derepression of target genes in the Salvador-Warts-Hippo (SWH) pathway.
Title: The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements.
Results define an important role for Wbp2 as a downstream component of the Salvador-Warts-Hippo tissue growth-control pathway.
Title: Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway.
Salvador-Warts-Hippo pathway limits tissue growth by repressing the Yorkie transcriptional co-activator
Title: The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R8 cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippo signaling	TAS Traceable Author Statement more info	PubMed
involved_in imaginal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of organ growth	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of imaginal disc growth	TAS Traceable Author Statement more info	PubMed
involved_in response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal cell programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apicomedial cortex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed