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FUT3 fucosyltransferase 3 (Lewis blood group) [ Homo sapiens (human) ]

Gene ID: 2525, updated on 27-Jun-2020

Summary

Official Symbol
FUT3provided by HGNC
Official Full Name
fucosyltransferase 3 (Lewis blood group)provided by HGNC
Primary source
HGNC:HGNC:4014
See related
Ensembl:ENSG00000171124 MIM:111100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LE; Les; FT3B; CD174; FucT-III
Summary
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon (RPKM 29.8), esophagus (RPKM 25.0) and 7 other tissues See more
Orthologs

Genomic context

See FUT3 in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (5842888..5857122, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5842899..5851485, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene neurturin Neighboring gene fucosyltransferase 6 Neighboring gene uncharacterized LOC101928844 Neighboring gene Sharpr-MPRA regulatory region 10376 Neighboring gene fucosyltransferase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
NHGRI GWA Catalog
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131739

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell-cell recognition IC
Inferred by Curator
more info
PubMed 
ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fucosylation IDA
Inferred from Direct Assay
more info
PubMed 
macromolecule glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
oligosaccharide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
Names
Lewis FT
alpha-(1,3/1,4)-fucosyltransferase
alpha-3-fucosyltransferase FUT3
blood group Lewis alpha-4-fucosyltransferase
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
fucosyltransferase III
galactoside 3(4)-L-fucosyltransferase
NP_000140.1
NP_001091108.3
NP_001091109.3
NP_001091110.3
NP_001361669.1
NP_001369673.1
NP_001369674.1
NP_001369675.1
NP_001369676.1
NP_001369677.1
NP_001369678.1
NP_001369679.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007482.1 RefSeqGene

    Range
    5001..13587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000149.4NP_000140.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    See identical proteins and their annotated locations for NP_000140.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as minor I, represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/Swiss-Prot
    P21217
    UniProtKB/TrEMBL
    A8K737
    Related
    ENSP00000305603.5, ENST00000303225.11
    Conserved Domains (2) summary
    pfam00852
    Location:189357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  2. NM_001097639.3NP_001091108.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as major II, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    Related
    ENSP00000465804.1, ENST00000589620.5
  3. NM_001097640.3NP_001091109.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as major I, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    Related
    ENSP00000468123.1, ENST00000589918.5
  4. NM_001097641.3NP_001091110.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as minor II, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    Related
    ENSP00000416443.1, ENST00000458379.7
  5. NM_001374740.1NP_001361669.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
  6. NM_001382744.1NP_001369673.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
  7. NM_001382745.1NP_001369674.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
  8. NM_001382746.1NP_001369675.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
  9. NM_001382747.1NP_001369676.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
  10. NM_001382748.1NP_001369677.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
  11. NM_001382749.1NP_001369678.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
  12. NM_001382750.1NP_001369679.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    5842888..5857122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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