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FUT3 fucosyltransferase 3 (Lewis blood group) [ Homo sapiens (human) ]

Gene ID: 2525, updated on 17-Oct-2021

Summary

Official Symbol
FUT3provided by HGNC
Official Full Name
fucosyltransferase 3 (Lewis blood group)provided by HGNC
Primary source
HGNC:HGNC:4014
See related
Ensembl:ENSG00000171124 MIM:111100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LE; Les; FT3B; CD174; FucT-III
Summary
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection. [provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Expression
Biased expression in colon (RPKM 29.8), esophagus (RPKM 25.0) and 7 other tissues See more
Orthologs
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Genomic context

See FUT3 in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (5842888..5857122, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5842899..5857133, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene neurturin Neighboring gene fucosyltransferase 6 Neighboring gene uncharacterized LOC101928844 Neighboring gene Sharpr-MPRA regulatory region 10376 Neighboring gene fucosyltransferase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Blood group, lewis system
MedGen: C0023595 OMIM: 618983 GeneReviews: Not available
not available
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
GeneReviews: Not available
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131739

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
Names
Lewis FT
alpha-(1,3/1,4)-fucosyltransferase
alpha-3-fucosyltransferase FUT3
blood group Lewis alpha-4-fucosyltransferase
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
fucosyltransferase III
galactoside 3(4)-L-fucosyltransferase
truncated fucosyltransferase 3
NP_000140.1
NP_001091108.3
NP_001091109.3
NP_001091110.3
NP_001361669.1
NP_001369673.1
NP_001369674.1
NP_001369675.1
NP_001369676.1
NP_001369677.1
NP_001369678.1
NP_001369679.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007482.2 RefSeqGene

    Range
    10674..19235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_800

mRNA and Protein(s)

  1. NM_000149.4NP_000140.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    See identical proteins and their annotated locations for NP_000140.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as minor I, represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/Swiss-Prot
    P21217
    UniProtKB/TrEMBL
    A8K737
    Related
    ENSP00000305603.5, ENST00000303225.11
    Conserved Domains (2) summary
    pfam00852
    Location:189357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  2. NM_001097639.3NP_001091108.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as major II, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    Related
    ENSP00000465804.1, ENST00000589620.5
    Conserved Domains (2) summary
    pfam00852
    Location:189357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  3. NM_001097640.3NP_001091109.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as major I, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    Related
    ENSP00000468123.1, ENST00000589918.5
    Conserved Domains (2) summary
    pfam00852
    Location:189357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  4. NM_001097641.3NP_001091110.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as minor II, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    Related
    ENSP00000416443.1, ENST00000458379.7
    Conserved Domains (2) summary
    pfam00852
    Location:189357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  5. NM_001374740.1NP_001361669.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Conserved Domains (2) summary
    pfam00852
    Location:189357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  6. NM_001382744.1NP_001369673.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Conserved Domains (2) summary
    pfam00852
    Location:189357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  7. NM_001382745.1NP_001369674.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Conserved Domains (2) summary
    pfam00852
    Location:189357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  8. NM_001382746.1NP_001369675.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Conserved Domains (2) summary
    pfam00852
    Location:189357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  9. NM_001382747.1NP_001369676.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Conserved Domains (2) summary
    pfam00852
    Location:189357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  10. NM_001382748.1NP_001369677.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Conserved Domains (2) summary
    pfam00852
    Location:189357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  11. NM_001382749.1NP_001369678.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Conserved Domains (2) summary
    pfam00852
    Location:189357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  12. NM_001382750.1NP_001369679.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Conserved Domains (2) summary
    pfam00852
    Location:189357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    5842888..5857122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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