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Gata1 GATA binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25172, updated on 22-Sep-2022

Summary

Symbol
Gata1provided by RGD
Full Name
GATA binding protein 1provided by RGD
Primary source
RGD:2663
See related
Ensembl:ENSRNOG00000047663 AllianceGenome:RGD:2663
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Eryf1
Summary
Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in several processes, including Sertoli cell development; cellular response to cAMP; and cellular response to follicle-stimulating hormone stimulus. Located in nucleus. Biomarker of mental depression and polycythemia. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; X-linked recessive disease (multiple); bone marrow cancer (multiple); colon adenocarcinoma; and myeloid leukemia associated with Down Syndrome. Orthologous to human GATA1 (GATA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 100.0) and Testes (RPKM 9.9) See more
Orthologs
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Genomic context

See Gata1 in Genome Data Viewer
Location:
Xq12
Exon count:
6
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14529706..14537530)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15273937..15281759)

Chromosome X - NC_051356.1Genomic Context describing neighboring genes Neighboring gene glyoxalase domain containing 5 Neighboring gene Annexin A7, pseudogene 3 Neighboring gene uncharacterized LOC102554502 Neighboring gene U2 spliceosomal RNA Neighboring gene histone deacetylase 6

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding, bending ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in Sertoli cell development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in animal organ regeneration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in basophil differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to follicle-stimulating hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to thyroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
involved_in eosinophil differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in eosinophil fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in erythrocyte development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of myeloid cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within platelet formation ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within primitive erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of definitive erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glycoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of primitive erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
erythroid transcription factor
Names
GATA-1
GATA-binding factor 1
GATA-binding protein 1 (globin transcription factor 1)
GF-1
NF-E1 DNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012764.2NP_036896.1  erythroid transcription factor

    See identical proteins and their annotated locations for NP_036896.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000351
    UniProtKB/Swiss-Prot
    P43429
    Related
    ENSRNOP00000067336.1, ENSRNOT00000075082.3
    Conserved Domains (2) summary
    smart00401
    Location:202247
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:203249
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051356.1 Reference mRatBN7.2 Primary Assembly

    Range
    14529706..14537530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)