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Gata1 GATA binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25172, updated on 12-Aug-2018

Summary

Official Symbol
Gata1provided by RGD
Official Full Name
GATA binding protein 1provided by RGD
Primary source
RGD:2663
See related
Ensembl:ENSRNOG00000047663
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Eryf1
Summary
transcription factor that may regulate transcription of serine dehydratase [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 100.0) and Testes (RPKM 9.9) See more
Orthologs

Genomic context

See Gata1 in Genome Data Viewer
Location:
Xq12
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15273937..15281759)
104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (16054178..16062000)

Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene glyoxalase domain containing 5 Neighboring gene annexin A7-like Neighboring gene histone deacetylase 6 Neighboring gene ES cell expressed Ras

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
C2H2 zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding, bending ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
p53 binding ISO
Inferred from Sequence Orthology
more info
 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Sertoli cell development IEP
Inferred from Expression Pattern
more info
PubMed 
anatomical structure formation involved in morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
animal organ regeneration IDA
Inferred from Direct Assay
more info
PubMed 
basophil differentiation IEA
Inferred from Electronic Annotation
more info
 
basophil differentiation ISO
Inferred from Sequence Orthology
more info
 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell development ISO
Inferred from Sequence Orthology
more info
 
cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
cellular response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to follicle-stimulating hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to thyroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
eosinophil differentiation IEA
Inferred from Electronic Annotation
more info
 
eosinophil differentiation ISO
Inferred from Sequence Orthology
more info
 
eosinophil fate commitment ISO
Inferred from Sequence Orthology
more info
 
erythrocyte development IEA
Inferred from Electronic Annotation
more info
 
erythrocyte development ISO
Inferred from Sequence Orthology
more info
 
erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
megakaryocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
platelet formation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of definitive erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of glycoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of primitive erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
transcriptional activation by promoter-enhancer looping ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
transcriptional repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
erythroid transcription factor
Names
GATA-1
GATA-binding factor 1
GATA-binding protein 1 (globin transcription factor 1)
GF-1
NF-E1 DNA-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012764.1NP_036896.1  erythroid transcription factor

    See identical proteins and their annotated locations for NP_036896.1

    Status: PROVISIONAL

    Source sequence(s)
    D13518
    UniProtKB/Swiss-Prot
    P43429
    Related
    ENSRNOP00000067336.1, ENSRNOT00000075082.2
    Conserved Domains (2) summary
    smart00401
    Location:202247
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:203249
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

    Range
    15273937..15281759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000089.1 Alternate Rn_Celera

    Range
    14614331..14622295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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