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ALPG alkaline phosphatase, germ cell [ Homo sapiens (human) ]

Gene ID: 251, updated on 12-Oct-2019

Summary

Official Symbol
ALPGprovided by HGNC
Official Full Name
alkaline phosphatase, germ cellprovided by HGNC
Primary source
HGNC:HGNC:441
See related
Ensembl:ENSG00000163286 MIM:171810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCAP; ALPPL; ALPPL2
Summary
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 6.1), lung (RPKM 0.8) and 1 other tissue See more
Orthologs

Genomic context

See ALPG in Genome Data Viewer
Location:
2q37.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (232406844..232410714)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (233271552..233275424)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene alkaline phosphatase, placental Neighboring gene endothelin converting enzyme like 1 pseudogene 2 Neighboring gene uncharacterized LOC107985999 Neighboring gene endothelin converting enzyme like 1 pseudogene 1 Neighboring gene DIS3 like 3'-5' exoribonuclease 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alkaline phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
alkaline phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
alkaline phosphatase, germ cell type
Names
ALP-1
Nagao isozyme
alkaline phosphatase Nagao isozyme
alkaline phosphatase, placental like 2
alkaline phosphatase, placental-like
germ cell alkaline phosphatase
placental-like alkaline phosphatase
testicular and thymus alkaline phosphatase
NP_112603.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031313.3NP_112603.2  alkaline phosphatase, germ cell type preproprotein

    See identical proteins and their annotated locations for NP_112603.2

    Status: REVIEWED

    Source sequence(s)
    AI982769, BC014139, DB194270, J04948
    Consensus CDS
    CCDS2491.1
    UniProtKB/Swiss-Prot
    P10696
    Related
    ENSP00000295453.3, ENST00000295453.8
    Conserved Domains (2) summary
    PRK10518
    Location:25475
    PRK10518; alkaline phosphatase; Provisional
    pfam00245
    Location:52487
    Alk_phosphatase; Alkaline phosphatase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    232406844..232410714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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