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ALPG alkaline phosphatase, germ cell [ Homo sapiens (human) ]

Gene ID: 251, updated on 18-Sep-2024

Summary

Official Symbol
ALPGprovided by HGNC
Official Full Name
alkaline phosphatase, germ cellprovided by HGNC
Primary source
HGNC:HGNC:441
See related
Ensembl:ENSG00000163286 MIM:171810; AllianceGenome:HGNC:441
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCAP; ALPPL; ALPPL2
Summary
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 6.1), lung (RPKM 0.8) and 1 other tissue See more
Orthologs
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Genomic context

See ALPG in Genome Data Viewer
Location:
2q37.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (232406844..232410714)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (232893640..232897508)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (233271554..233275424)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124906123 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:233243260-233244227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233245487-233246037 Neighboring gene alkaline phosphatase, placental Neighboring gene endothelin converting enzyme like 1 pseudogene 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:233271618-233272817 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233273180-233273680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233273681-233274181 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:233282988-233283771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:233284555-233285338 Neighboring gene endothelin converting enzyme like 1 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:233287601-233288368 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:233288369-233289136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:233296883-233297704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233303996-233304499 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233304500-233305004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233308216-233308853 Neighboring gene DIS3 like 3'-5' exoribonuclease 2 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233310961-233311462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233311463-233311962

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alkaline phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables alkaline phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alkaline phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alkaline phosphatase, germ cell type
Names
ALP-1
Nagao isozyme
alkaline phosphatase Nagao isozyme
alkaline phosphatase, placental like 2
alkaline phosphatase, placental-like
germ cell alkaline phosphatase
placental-like alkaline phosphatase
testicular and thymus alkaline phosphatase
NP_112603.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031313.3NP_112603.2  alkaline phosphatase, germ cell type preproprotein

    See identical proteins and their annotated locations for NP_112603.2

    Status: REVIEWED

    Source sequence(s)
    AI982769, BC014139, DB194270, J04948
    Consensus CDS
    CCDS2491.1
    UniProtKB/Swiss-Prot
    A8KAF2, P10696, Q16727, Q53S81, Q96CM1
    UniProtKB/TrEMBL
    B2R7C7
    Related
    ENSP00000295453.3, ENST00000295453.8
    Conserved Domains (1) summary
    pfam00245
    Location:52487
    Alk_phosphatase; Alkaline phosphatase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    232406844..232410714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    232893640..232897508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)