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Pth parathyroid hormone [ Rattus norvegicus (Norway rat) ]

Gene ID: 24694, updated on 17-Nov-2020

Summary

Official Symbol
Pthprovided by RGD
Official Full Name
parathyroid hormoneprovided by RGD
Primary source
RGD:3440
See related
Ensembl:ENSRNOG00000014318
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pth1; Pthr1; PTH-(1-84)
Summary
regulates osteoblast proliferation and differentiation; involved in G-protein coupled receptor mediated adenylate cyclase activation [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 25.4) See more
Orthologs

Genomic context

See Pth in Genome Data Viewer
Location:
1q33
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (178215829..178218761, complement)
106 current Rn_Celera (GCF_000002265.2) 1 AC_000069.1 (165378267..165381199, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (185183456..185186388, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene aryl hydrocarbon receptor nuclear translocator-like Neighboring gene BTB domain containing 10 Neighboring gene proteasome maturation protein-like Neighboring gene similar to Alpha-enolase (2-phospho-D-glycerate hydro-lyase) (Non-neural enolase) (NNE) (Enolase 1)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hormone activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
hormone activity ISO
Inferred from Sequence Orthology
more info
 
parathyroid hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
parathyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
peptide hormone receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptide hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
peptide hormone receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
receptor ligand activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
type 1 parathyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
type 1 parathyroid hormone receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
type 1 parathyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
bone resorption TAS
Traceable Author Statement
more info
PubMed 
calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
cellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular macromolecule biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
 
magnesium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process in bone marrow cell ISO
Inferred from Sequence Orthology
more info
 
negative regulation of bone mineralization involved in bone maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
ossification TAS
Traceable Author Statement
more info
PubMed 
phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bone mineralization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation in bone marrow ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of inositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ossification IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoclast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to fibroblast growth factor IEP
Inferred from Expression Pattern
more info
PubMed 
response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
response to parathyroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin D IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
parathyroid hormone
Names
hypothalamic parathyroid hormone
parathyrin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017044.1NP_058740.1  parathyroid hormone precursor

    See identical proteins and their annotated locations for NP_058740.1

    Status: PROVISIONAL

    Source sequence(s)
    X05721
    UniProtKB/Swiss-Prot
    P04089
    Related
    ENSRNOP00000019199.1, ENSRNOT00000019199.2
    Conserved Domains (1) summary
    smart00087
    Location:3065
    PTH; Parathyroid hormone

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    178215829..178218761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    165378267..165381199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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