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CTAG1A cancer/testis antigen 1A [ Homo sapiens (human) ]

Gene ID: 246100, updated on 17-Jun-2019

Summary

Official Symbol
CTAG1Aprovided by HGNC
Official Full Name
cancer/testis antigen 1Aprovided by HGNC
Primary source
HGNC:HGNC:24198
See related
Ensembl:ENSG00000268651 MIM:300657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESO1; CT6.1; LAGE-2; LAGE2A; NY-ESO-1
Summary
The protein encoded by this gene is a tumor cell antigen found in various types of cancers, which makes it a good candidate for a cancer vaccine. This gene is also highly expressed in normal ovary and testis tissues. An identical copy of this gene is found on the same chromosome. [provided by RefSeq, Dec 2015]
Expression
Restricted expression toward testis (RPKM 4.4) See more

Genomic context

See CTAG1A in Genome Data Viewer
Location:
Xq28
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (154585133..154586816)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153813418..153815075)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 223 member A Neighboring gene activating transcription factor 4 pseudogene 2 Neighboring gene cancer/testis antigen 1B Neighboring gene activating transcription factor 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA threonylcarbamoyladenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cancer/testis antigen 1
Names
New York Esophageal Squamous Cell Carcinoma 1
autoimmunogenic cancer/testis antigen NY-ESO-1
cancer/testis antigen 1-A
cancer/testis antigen 6.1
l antigen family member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139250.2NP_640343.1  cancer/testis antigen 1

    See identical proteins and their annotated locations for NP_640343.1

    Status: REVIEWED

    Source sequence(s)
    AC244090
    Consensus CDS
    CCDS44025.1
    UniProtKB/Swiss-Prot
    P78358
    Related
    ENSP00000469441.1, ENST00000599837.3
    Conserved Domains (1) summary
    pfam09341
    Location:92162
    Pcc1; Transcription factor Pcc1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    154585133..154586816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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