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CTAG1A cancer/testis antigen 1A [ Homo sapiens (human) ]

Gene ID: 246100, updated on 2-Nov-2024

Summary

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Official Symbol
CTAG1Aprovided by HGNC
Official Full Name
cancer/testis antigen 1Aprovided by HGNC
Primary source
HGNC:HGNC:24198
See related
Ensembl:ENSG00000268651 MIM:300657; AllianceGenome:HGNC:24198
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESO1; CT6.1; LAGE-2; LAGE2A; NY-ESO-1
Summary
The protein encoded by this gene is a tumor cell antigen found in various types of cancers, which makes it a good candidate for a cancer vaccine. This gene is also highly expressed in normal ovary and testis tissues. An identical copy of this gene is found on the same chromosome. [provided by RefSeq, Dec 2015]
Expression
Restricted expression toward testis (RPKM 4.4) See more
Orthologs
all
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Genomic context

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See CTAG1A in Genome Data Viewer
Location:
Xq28
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154585133..154586816)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152821564..152823242)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153813397..153815075)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 223 member A Neighboring gene activating transcription factor 4 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:153825347-153825934 Neighboring gene cancer/testis antigen 1B Neighboring gene activating transcription factor 4 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evaluation of cellular immune responses in cancer vaccine recipients: lessons from NY-ESO-1. Cebon J, et al. Expert Rev Vaccines, 2010 Jun. PMID 20518717
  2. Screening for biomarkers of spermatogonia within the human testis: a whole genome approach. von Kopylow K, et al. Hum Reprod, 2010 May. PMID 20208059
  3. Involvement of NY-ESO-1 and MAGE-A4 in the pathogenesis of desmoid tumors. Hashimoto K, et al. Medicine (Baltimore), 2023 Jun 2. PMID 37266606, Free PMC Article
  4. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Chen YT, et al. Proc Natl Acad Sci U S A, 1997 Mar 4. PMID 9050879, Free PMC Article
  5. Genomic cloning and localization of CTAG, a gene encoding an autoimmunogenic cancer-testis antigen NY-ESO-1, to human chromosome Xq28. Chen YT, et al. Cytogenet Cell Genet, 1997. PMID 9605863

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression and Prognostic Significance of PD-L1 and NY-ESO1 in Gallbladder Carcinoma.
    Title: Expression and Prognostic Significance of PD-L1 and NY-ESO1 in Gallbladder Carcinoma.
  2. Involvement of NY-ESO-1 and MAGE-A4 in the pathogenesis of desmoid tumors.
    Title: Involvement of NY-ESO-1 and MAGE-A4 in the pathogenesis of desmoid tumors.
  3. Expression may represent potential targets for cancer immunotherapy in patients with non small cell lung carcinoma.
    Title: Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
cancer/testis antigen 1
Names
New York Esophageal Squamous Cell Carcinoma 1
autoimmunogenic cancer/testis antigen NY-ESO-1
cancer/testis antigen 1-A
cancer/testis antigen 6.1
l antigen family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139250.2 → NP_640343.1  cancer/testis antigen 1

    See identical proteins and their annotated locations for NP_640343.1

    Status: REVIEWED

    Source sequence(s)
    AC244090
    Consensus CDS
    CCDS44025.1
    UniProtKB/Swiss-Prot
    A1L417, B7WNL9, P78358, Q7LBY4, Q9NY13
    Related
    ENSP00000469441.1, ENST00000599837.3
    Conserved Domains (1) summary
    pfam09341
    Location:92 → 162
    Pcc1; Transcription factor Pcc1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    154585133..154586816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    152821564..152823242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P78358.1 GenPept UniProtKB/Swiss-Prot:P78358

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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