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ALOX15 arachidonate 15-lipoxygenase [ Homo sapiens (human) ]

Gene ID: 246, updated on 10-Jun-2018
Official Symbol
ALOX15provided by HGNC
Official Full Name
arachidonate 15-lipoxygenaseprovided by HGNC
Primary source
HGNC:HGNC:433
See related
Ensembl:ENSG00000161905 MIM:152392; Vega:OTTHUMG00000090746
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LOG15; 12-LOX; 15-LOX; 15-LOX-1
Summary
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
Expression
Biased expression in lung (RPKM 5.0), small intestine (RPKM 1.7) and 11 other tissues See more
Orthologs
See ALOX15 in Genome Data Viewer
Location:
17p13.2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (4630919..4641673, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4534214..4545583, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1996 Neighboring gene uncharacterized LOC105371498 Neighboring gene RNA, U6 small nuclear 955, pseudogene Neighboring gene uncharacterized LOC105371499 Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene uncharacterized LOC101559451

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Arachidonic acid metabolism, organism-specific biosystem (from KEGG)
    Arachidonic acid metabolism, organism-specific biosystem
    Arachidonic acid metabolism
  • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
    Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
  • Arachidonic acid metabolism, conserved biosystem (from KEGG)
    Arachidonic acid metabolism, conserved biosystem
    Arachidonic acid metabolism
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Eicosanoid Synthesis, organism-specific biosystem (from WikiPathways)
    Eicosanoid Synthesis, organism-specific biosystemIn biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or i...
  • Ferroptosis, organism-specific biosystem (from KEGG)
    Ferroptosis, organism-specific biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
  • Ferroptosis, conserved biosystem (from KEGG)
    Ferroptosis, conserved biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
  • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL4-mediated signaling events, organism-specific biosystem
    IL4-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
  • Linoleic acid metabolism, organism-specific biosystem (from KEGG)
    Linoleic acid metabolism, organism-specific biosystem
    Linoleic acid metabolism
  • Linoleic acid metabolism, conserved biosystem (from KEGG)
    Linoleic acid metabolism, conserved biosystem
    Linoleic acid metabolism
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Serotonergic synapse, organism-specific biosystem (from KEGG)
    Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Synthesis of 12-eicosatetraenoic acid derivatives, organism-specific biosystem (from REACTOME)
    Synthesis of 12-eicosatetraenoic acid derivatives, organism-specific biosystemThe 12-eicosatetraenoic acids: 12-hydroperoxy-eicosatetraenoic acid (12-HpETE), 12-hydroxyeicosatetraenoic acid (12-HETE) and 12-oxo-eicosatetraenoic acid (12-oxoETE) are formed after the initial ste...
  • Synthesis of 15-eicosatetraenoic acid derivatives, organism-specific biosystem (from REACTOME)
    Synthesis of 15-eicosatetraenoic acid derivatives, organism-specific biosystemThe 15-eicosatetraenoic acids: 15-hydroperoxy-eicosatetraenoic acid (15-HpETE), 15-hydroxyeicosatetraenoic acid (15-HETE) and 15-oxo-eicosatetraenoic acid (15-oxoETE) are formed after the initial st...
  • Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystem (from REACTOME)
    Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystemLeukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attracti...
  • lipoxin biosynthesis, organism-specific biosystem (from BIOCYC)
    lipoxin biosynthesis, organism-specific biosystemGeneral Background Lipoxins belong to the eicosanoid family, have a distinct conjugated tetraene structure and are generated from : ARACHIDONIC_ACID during inflammation. They consist of two distinct...
  • lipoxin biosynthesis, conserved biosystem (from BIOCYC)
    lipoxin biosynthesis, conserved biosystemGeneral Background Lipoxins belong to the eicosanoid family, have a distinct conjugated tetraene structure and are generated from |FRAME: ARACHIDONIC_ACID| during inflammation. They consist of two d...
  • resolvin D biosynthesis, organism-specific biosystem (from BIOCYC)
    resolvin D biosynthesis, organism-specific biosystemGeneral Background The ω 3 polyunsaturated fatty acids are known to be essential for proper neuronal and immune function. Deficiencies in these important fatty acids are associated with mental...
  • resolvin D biosynthesis, conserved biosystem (from BIOCYC)
    resolvin D biosynthesis, conserved biosystemGeneral Background The ω 3 polyunsaturated fatty acids are essential for proper neuronal and immune function. Deficiencies in these important fatty acids are associated with mental dysfunction...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arachidonate 12-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
arachidonate 12-lipoxygenase activity TAS
Traceable Author Statement
more info
 
arachidonate 15-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
arachidonate 15-lipoxygenase activity NAS
Non-traceable Author Statement
more info
PubMed 
arachidonate 15-lipoxygenase activity TAS
Traceable Author Statement
more info
 
eoxin A4 synthase activity TAS
Traceable Author Statement
more info
 
hepoxilin A3 synthase activity IEA
Inferred from Electronic Annotation
more info
 
hepoxilin-epoxide hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic cell clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
arachidonic acid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interleukin-13 IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
hepoxilin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
leukotriene metabolic process TAS
Traceable Author Statement
more info
 
lipoxin A4 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
lipoxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
lipoxygenase pathway TAS
Traceable Author Statement
more info
 
long-chain fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 
negative regulation of adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
ossification ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylethanolamine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of engulfment of apoptotic cell ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of peroxisome proliferator activated receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
arachidonate 15-lipoxygenase
Names
12/15-lipoxygenase
15-LOX type 1
15-lipooxygenase-1
15-lipoxygenase type 1
arachidonate 12-lipoxygenase, leukocyte-type
arachidonate omega-6 lipoxygenase
NP_001131.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001140.4NP_001131.3  arachidonate 15-lipoxygenase

    See identical proteins and their annotated locations for NP_001131.3

    Status: REVIEWED

    Source sequence(s)
    BC029032, DC346318, M23892
    Consensus CDS
    CCDS11049.1
    UniProtKB/Swiss-Prot
    P16050
    Related
    ENSP00000293761.3, ENST00000293761.7
    Conserved Domains (2) summary
    cd01753
    Location:2111
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:219653
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    4630919..4641673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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