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ALOX15 arachidonate 15-lipoxygenase [ Homo sapiens (human) ]

Gene ID: 246, updated on 4-Dec-2023

Summary

Official Symbol
ALOX15provided by HGNC
Official Full Name
arachidonate 15-lipoxygenaseprovided by HGNC
Primary source
HGNC:HGNC:433
See related
Ensembl:ENSG00000161905 MIM:152392; AllianceGenome:HGNC:433
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LOG15; 12-LOX; 15-LOX; 15-LOX-1
Summary
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
Expression
Biased expression in lung (RPKM 5.0), small intestine (RPKM 1.7) and 11 other tissues See more
Orthologs
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Genomic context

See ALOX15 in Genome Data Viewer
Location:
17p13.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4630919..4641678, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4520655..4531416, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4534214..4544973, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1996 Neighboring gene uncharacterized LOC105371498 Neighboring gene RNA, U6 small nuclear 955, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4534741-4535270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4535271-4535798 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:4541217-4542416 Neighboring gene uncharacterized LOC105371499 Neighboring gene Sharpr-MPRA regulatory region 3058 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:4552879-4553094 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47177/47178 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47179 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47181 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47184 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47187 Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47196 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47199 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47200 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47201 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47204 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47205 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47206 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47207 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11544 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47211 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47214

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arachidonate 12(S)-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables arachidonate 12(S)-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arachidonate 15-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables arachidonate 15-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arachidonate 15-lipoxygenase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables arachidonate 15-lipoxygenase activity TAS
Traceable Author Statement
more info
 
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables linoleate 13S-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic cell clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in arachidonic acid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to interleukin-13 IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hepoxilin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hepoxilin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipoxin A4 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipoxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipoxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipoxygenase pathway TAS
Traceable Author Statement
more info
 
involved_in long-chain fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in negative regulation of adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ossification ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidylethanolamine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of engulfment of apoptotic cell ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of peroxisome proliferator activated receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
polyunsaturated fatty acid lipoxygenase ALOX15
Names
12/15-lipoxygenase
15-LOX type 1
15-lipooxygenase-1
15-lipoxygenase type 1
arachidonate 12-lipoxygenase, leukocyte-type
arachidonate omega-6 lipoxygenase
hepoxilin A3 synthase Alox15
linoleate 13S-lipoxygenase
NP_001131.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001140.5NP_001131.3  polyunsaturated fatty acid lipoxygenase ALOX15

    See identical proteins and their annotated locations for NP_001131.3

    Status: REVIEWED

    Source sequence(s)
    AK312557, BC029032, M23892
    Consensus CDS
    CCDS11049.1
    UniProtKB/Swiss-Prot
    A8K2P4, B7ZA11, P16050, Q8N6R7, Q99657
    UniProtKB/TrEMBL
    B2R6F7
    Related
    ENSP00000293761.3, ENST00000293761.8
    Conserved Domains (2) summary
    cd01753
    Location:2111
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:219653
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    4630919..4641678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    4520655..4531416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)