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Fat2 FAT atypical cadherin 2 [ Mus musculus (house mouse) ]

Gene ID: 245827, updated on 8-Dec-2022

Summary

Official Symbol
Fat2provided by MGI
Official Full Name
FAT atypical cadherin 2provided by MGI
Primary source
MGI:MGI:2685369
See related
Ensembl:ENSMUSG00000055333 AllianceGenome:MGI:2685369
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EMI2; Fath2; Gm523; mKIAA0811
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cell-substrate adhesion; epithelial cell migration; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within cell adhesion. Predicted to be located in Golgi apparatus; cell junction; and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in adherens junction. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; nose; and urinary system. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 45. Orthologous to human FAT2 (FAT atypical cadherin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 20.8) and bladder adult (RPKM 3.4) See more
Orthologs
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Genomic context

See Fat2 in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55141435..55228331, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55250609..55337505, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 1, opposite strand Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 1 Neighboring gene predicted gene, 31842 Neighboring gene secreted acidic cysteine rich glycoprotein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029988.2NP_001025159.1  protocadherin Fat 2 precursor

    See identical proteins and their annotated locations for NP_001025159.1

    Status: PROVISIONAL

    Source sequence(s)
    AK132523, AK173031, AL713870
    Consensus CDS
    CCDS36157.1
    UniProtKB/Swiss-Prot
    Q5F226, Q69ZY7
    Related
    ENSMUSP00000104492.2, ENSMUST00000108864.2
    Conserved Domains (5) summary
    cd11304
    Location:33283424
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:39533986
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:39924022
    EGF; EGF-like domain
    cl29226
    Location:18831959
    Cadherin; Cadherin domain
    pfam02210
    Location:38023920
    Laminin_G_2; Laminin G domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    55141435..55228331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533322.4XP_006533385.1  protocadherin Fat 2 isoform X1

    See identical proteins and their annotated locations for XP_006533385.1

    UniProtKB/Swiss-Prot
    Q5F226, Q69ZY7
    Conserved Domains (5) summary
    cd11304
    Location:33283424
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:39533986
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:39924022
    EGF; EGF-like domain
    cl29226
    Location:18831959
    Cadherin; Cadherin domain
    pfam02210
    Location:38023920
    Laminin_G_2; Laminin G domain
  2. XM_030246003.1XP_030101863.1  protocadherin Fat 2 isoform X1

    UniProtKB/Swiss-Prot
    Q69ZY7
    Related
    ENSMUSP00000067556.7, ENSMUST00000068853.13
    Conserved Domains (5) summary
    cd11304
    Location:33283424
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:39533986
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:39924022
    EGF; EGF-like domain
    cl29226
    Location:18831959
    Cadherin; Cadherin domain
    pfam02210
    Location:38023920
    Laminin_G_2; Laminin G domain
  3. XM_006533323.4XP_006533386.1  protocadherin Fat 2 isoform X1

    See identical proteins and their annotated locations for XP_006533386.1

    UniProtKB/Swiss-Prot
    Q5F226, Q69ZY7
    Conserved Domains (5) summary
    cd11304
    Location:33283424
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:39533986
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:39924022
    EGF; EGF-like domain
    cl29226
    Location:18831959
    Cadherin; Cadherin domain
    pfam02210
    Location:38023920
    Laminin_G_2; Laminin G domain

RNA

  1. XR_004936961.1 RNA Sequence