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Fat2 FAT atypical cadherin 2 [ Mus musculus (house mouse) ]

Gene ID: 245827, updated on 12-Aug-2019

Summary

Official Symbol
Fat2provided by MGI
Official Full Name
FAT atypical cadherin 2provided by MGI
Primary source
MGI:MGI:2685369
See related
Ensembl:ENSMUSG00000055333
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EMI2; Fath2; Gm523; mKIAA0811
Expression
Biased expression in cerebellum adult (RPKM 20.8) and bladder adult (RPKM 3.4) See more
Orthologs

Genomic context

See Fat2 in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
26
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55250609..55337505, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (55064112..55125759, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 1, opposite strand Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 1 Neighboring gene predicted gene, 31842 Neighboring gene secreted acidic cysteine rich glycoprotein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell-cell adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029988.2NP_001025159.1  protocadherin Fat 2 precursor

    See identical proteins and their annotated locations for NP_001025159.1

    Status: PROVISIONAL

    Source sequence(s)
    AK132523, AK173031, AL713870
    Consensus CDS
    CCDS36157.1
    UniProtKB/Swiss-Prot
    Q5F226
    Related
    ENSMUSP00000104492.1, ENSMUST00000108864.1
    Conserved Domains (5) summary
    cd11304
    Location:33283424
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:39533986
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:39924022
    EGF; EGF-like domain
    pfam02210
    Location:38023923
    Laminin_G_2; Laminin G domain
    cl09101
    Location:18771959
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    55250609..55337505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533322.4XP_006533385.1  protocadherin Fat 2 isoform X1

    See identical proteins and their annotated locations for XP_006533385.1

    UniProtKB/Swiss-Prot
    Q5F226
    Conserved Domains (5) summary
    cd11304
    Location:33283424
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:39533986
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:39924022
    EGF; EGF-like domain
    pfam02210
    Location:38023923
    Laminin_G_2; Laminin G domain
    cl09101
    Location:18771959
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
  2. XM_030246003.1XP_030101863.1  protocadherin Fat 2 isoform X1

    Related
    ENSMUSP00000067556.6, ENSMUST00000068853.12
  3. XM_006533323.4XP_006533386.1  protocadherin Fat 2 isoform X1

    See identical proteins and their annotated locations for XP_006533386.1

    UniProtKB/Swiss-Prot
    Q5F226
    Conserved Domains (5) summary
    cd11304
    Location:33283424
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:39533986
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:39924022
    EGF; EGF-like domain
    pfam02210
    Location:38023923
    Laminin_G_2; Laminin G domain
    cl09101
    Location:18771959
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
  4. XM_011249019.3XP_011247321.1  protocadherin Fat 2 isoform X2

    Conserved Domains (2) summary
    cd11304
    Location:11411238
    Cadherin_repeat; Cadherin tandem repeat domain
    cl09101
    Location:18771959
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
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