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FRK fyn related Src family tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 2444, updated on 17-Jun-2019

Summary

Official Symbol
FRKprovided by HGNC
Official Full Name
fyn related Src family tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:3955
See related
Ensembl:ENSG00000111816 MIM:606573
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTK; RAK; PTK5
Summary
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 3.0), duodenum (RPKM 2.8) and 23 other tissues See more
Orthologs

Genomic context

See FRK in Genome Data Viewer
Location:
6q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (115931149..116100739, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (116262691..116397360, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377961 Neighboring gene long intergenic non-protein coding RNA 2534 Neighboring gene triosephosphate isomerase 1 pseudogene 3 Neighboring gene 5'-nucleotidase domain containing 1 Neighboring gene collagen type X alpha 1 chain Neighboring gene NIP7 pseudogene 3 Neighboring gene TSPY like 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
NHGRI GWA Catalog

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
specific granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tyrosine-protein kinase FRK
Names
PTK5 protein tyrosine kinase 5
fyn-related kinase
nuclear tyrosine protein kinase RAK
protein-tyrosine kinase 5
NP_002022.1
XP_005266937.1
XP_005266938.1
XP_005266939.1
XP_011533955.1
XP_011533956.1
XP_011533957.1
XP_011533958.1
XP_016866134.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002031.3NP_002022.1  tyrosine-protein kinase FRK

    See identical proteins and their annotated locations for NP_002022.1

    Status: REVIEWED

    Source sequence(s)
    AL021451, AL121963, AL357141
    Consensus CDS
    CCDS5103.1
    UniProtKB/Swiss-Prot
    P42685
    Related
    ENSP00000476145.1, ENST00000606080.2
    Conserved Domains (3) summary
    cd10369
    Location:112207
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:47104
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:225494
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    115931149..116100739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535656.2XP_011533958.1  tyrosine-protein kinase FRK isoform X2

    Conserved Domains (3) summary
    cd05068
    Location:112381
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
    pfam07714
    Location:121374
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:394
    SH2; Src homology 2 (SH2) domain
  2. XM_011535655.2XP_011533957.1  tyrosine-protein kinase FRK isoform X1

    See identical proteins and their annotated locations for XP_011533957.1

    UniProtKB/Swiss-Prot
    P42685
    Conserved Domains (3) summary
    cd10369
    Location:112207
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:47104
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:225494
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
  3. XM_011535654.2XP_011533956.1  tyrosine-protein kinase FRK isoform X1

    See identical proteins and their annotated locations for XP_011533956.1

    UniProtKB/Swiss-Prot
    P42685
    Conserved Domains (3) summary
    cd10369
    Location:112207
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:47104
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:225494
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
  4. XM_005266882.4XP_005266939.1  tyrosine-protein kinase FRK isoform X1

    See identical proteins and their annotated locations for XP_005266939.1

    UniProtKB/Swiss-Prot
    P42685
    Conserved Domains (3) summary
    cd10369
    Location:112207
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:47104
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:225494
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
  5. XM_011535653.2XP_011533955.1  tyrosine-protein kinase FRK isoform X1

    See identical proteins and their annotated locations for XP_011533955.1

    UniProtKB/Swiss-Prot
    P42685
    Conserved Domains (3) summary
    cd10369
    Location:112207
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:47104
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:225494
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
  6. XM_017010645.1XP_016866134.1  tyrosine-protein kinase FRK isoform X1

    UniProtKB/Swiss-Prot
    P42685
    Conserved Domains (3) summary
    cd10369
    Location:112207
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:47104
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:225494
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
  7. XM_005266880.4XP_005266937.1  tyrosine-protein kinase FRK isoform X1

    See identical proteins and their annotated locations for XP_005266937.1

    UniProtKB/Swiss-Prot
    P42685
    Conserved Domains (3) summary
    cd10369
    Location:112207
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:47104
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:225494
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
  8. XM_005266881.2XP_005266938.1  tyrosine-protein kinase FRK isoform X1

    See identical proteins and their annotated locations for XP_005266938.1

    UniProtKB/Swiss-Prot
    P42685
    Conserved Domains (3) summary
    cd10369
    Location:112207
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:47104
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:225494
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
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