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Nlrp9b NLR family, pyrin domain containing 9B [ Mus musculus (house mouse) ]

Gene ID: 243874, updated on 8-Feb-2024

Summary

Official Symbol
Nlrp9bprovided by MGI
Official Full Name
NLR family, pyrin domain containing 9Bprovided by MGI
Primary source
MGI:MGI:2675377
See related
Ensembl:ENSMUSG00000060508 AllianceGenome:MGI:2675377
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nlrp9; Nalp9b; Nalp-delta
Summary
Predicted to enable ATP binding activity. Involved in defense response to other organism; positive regulation of interleukin-18 production; and pyroptosis. Predicted to be located in cytoplasm. Predicted to be part of inflammasome complex. Is expressed in early conceptus; gonad; and intestine. Orthologous to human NLRP9 (NLR family pyrin domain containing 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 5.3), small intestine adult (RPKM 1.7) and 4 other tissues See more
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Genomic context

See Nlrp9b in Genome Data Viewer
Location:
7 A3; 7 9.96 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19725318..19796867)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19991393..20062942)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A, pseudogene 8 Neighboring gene CEA cell adhesion molecule 20 Neighboring gene STARR-seq mESC enhancer starr_18236 Neighboring gene nuclear encoded rRNA 5S 152 Neighboring gene predicted gene 8432 Neighboring gene STARR-seq mESC enhancer starr_18237 Neighboring gene chromobox homolog 3 pseudogene Neighboring gene vomeronasal 1 receptor 91

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-18 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pyroptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of canonical inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of canonical inflammasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of canonical inflammasome complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NACHT, LRR and PYD domains-containing protein 9B
Names
NACHT, LRR and PYD containing protein 9b
NLR family, pyrin domain containing 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194058.2NP_918947.2  NACHT, LRR and PYD domains-containing protein 9B

    See identical proteins and their annotated locations for NP_918947.2

    Status: VALIDATED

    Source sequence(s)
    AY596196
    Consensus CDS
    CCDS20920.1
    UniProtKB/Swiss-Prot
    Q66X22, Q6UTW9
    UniProtKB/TrEMBL
    B9EIZ9
    Related
    ENSMUSP00000072895.7, ENSMUST00000073151.13
    Conserved Domains (6) summary
    cd08320
    Location:986
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:694722
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:144308
    NACHT; NACHT domain
    pfam17776
    Location:440555
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:387438
    NOD2_WH; NOD2 winged helix domain
    cl39015
    Location:752955
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19725318..19796867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539938.2XP_006540001.1  NACHT, LRR and PYD domains-containing protein 9B isoform X1

    See identical proteins and their annotated locations for XP_006540001.1

    UniProtKB/Swiss-Prot
    Q66X22, Q6UTW9
    UniProtKB/TrEMBL
    B9EIZ9
    Conserved Domains (6) summary
    cd08320
    Location:986
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:694722
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:144308
    NACHT; NACHT domain
    pfam17776
    Location:440555
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:387438
    NOD2_WH; NOD2 winged helix domain
    cl39015
    Location:752955
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. XM_006539939.2XP_006540002.1  NACHT, LRR and PYD domains-containing protein 9B isoform X1

    See identical proteins and their annotated locations for XP_006540002.1

    UniProtKB/Swiss-Prot
    Q66X22, Q6UTW9
    UniProtKB/TrEMBL
    B9EIZ9
    Conserved Domains (6) summary
    cd08320
    Location:986
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:694722
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:144308
    NACHT; NACHT domain
    pfam17776
    Location:440555
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:387438
    NOD2_WH; NOD2 winged helix domain
    cl39015
    Location:752955
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  3. XM_011250564.1XP_011248866.1  NACHT, LRR and PYD domains-containing protein 9B isoform X3

    UniProtKB/TrEMBL
    B9EIZ9
    Conserved Domains (6) summary
    cd08320
    Location:986
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00034
    Location:633667
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:144308
    NACHT; NACHT domain
    pfam17776
    Location:440555
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:387438
    NOD2_WH; NOD2 winged helix domain
    cl39015
    Location:692899
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  4. XM_011250563.1XP_011248865.1  NACHT, LRR and PYD domains-containing protein 9B isoform X2

    UniProtKB/TrEMBL
    B9EIZ9
    Conserved Domains (6) summary
    cd08320
    Location:986
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:639667
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:144308
    NACHT; NACHT domain
    pfam17776
    Location:440555
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:387438
    NOD2_WH; NOD2 winged helix domain
    cl39015
    Location:697900
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  5. XM_011250565.1XP_011248867.1  NACHT, LRR and PYD domains-containing protein 9B isoform X4

    UniProtKB/TrEMBL
    B9EIZ9
    Conserved Domains (6) summary
    cd08320
    Location:986
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00034
    Location:633667
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:144308
    NACHT; NACHT domain
    pfam17776
    Location:440555
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:387438
    NOD2_WH; NOD2 winged helix domain
    cl39015
    Location:692839
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...