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Nyap1 neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1 [ Mus musculus (house mouse) ]

Gene ID: 243300, updated on 11-Apr-2024

Summary

Official Symbol
Nyap1provided by MGI
Official Full Name
neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1provided by MGI
Primary source
MGI:MGI:2443880
See related
Ensembl:ENSMUSG00000045348 AllianceGenome:MGI:2443880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6430598A04Rik
Summary
Involved in neuron projection morphogenesis and phosphatidylinositol 3-kinase signaling. Is expressed in central nervous system; neural retina; nucleus pulposus; and spinal ganglion. Orthologous to human NYAP1 (neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 38.4), CNS E18 (RPKM 37.3) and 12 other tissues See more
Orthologs
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Genomic context

Location:
5 G2; 5 76.62 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137729144..137739430, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137730882..137741168, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15498 Neighboring gene predicted gene, 54308 Neighboring gene Sp110 nuclear body protein, pseudogene 2 Neighboring gene Tsc22 domain family, member 4 Neighboring gene predicted gene, 57848 Neighboring gene sperm acrosome developmental regulator

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1
Names
neuronal tyrosine phosphorylated adaptor for phosphoinositide 3-kinase adaptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347505.1NP_001334434.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC124730, AC125063
    Consensus CDS
    CCDS84980.1
    UniProtKB/TrEMBL
    E9PXJ0
    Related
    ENSMUSP00000148318.2, ENSMUST00000212152.2
    Conserved Domains (2) summary
    pfam15439
    Location:4413
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:577832
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
  2. NM_175521.4NP_780730.2  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform 1

    See identical proteins and their annotated locations for NP_780730.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK032567, BC057372, CJ292493
    Consensus CDS
    CCDS19775.1
    UniProtKB/Swiss-Prot
    E1CB66, Q3UF51, Q6PFX7, Q8BNR4, Q8CCL6
    UniProtKB/TrEMBL
    E9PXJ0
    Related
    ENSMUSP00000113397.2, ENSMUST00000118326.8
    Conserved Domains (2) summary
    pfam15439
    Location:15410
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:571833
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137729144..137739430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504576.5XP_006504639.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1

    See identical proteins and their annotated locations for XP_006504639.1

    UniProtKB/TrEMBL
    E9PXJ0
    Conserved Domains (2) summary
    pfam15439
    Location:4413
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:577832
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
  2. XM_006504577.5XP_006504640.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1

    See identical proteins and their annotated locations for XP_006504640.1

    UniProtKB/TrEMBL
    E9PXJ0
    Conserved Domains (2) summary
    pfam15439
    Location:4413
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:577832
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter