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Nyap1 neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1 [ Mus musculus (house mouse) ]

Gene ID: 243300, updated on 26-Sep-2022

Summary

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Official Symbol
Nyap1provided by MGI
Official Full Name
neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1provided by MGI
Primary source
MGI:MGI:2443880
See related
Ensembl:ENSMUSG00000045348 AllianceGenome:MGI:2443880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6430598A04Rik
Summary
Involved in neuron projection morphogenesis and phosphatidylinositol 3-kinase signaling. Is expressed in central nervous system; neural retina; nucleus pulposus; and spinal ganglion. Orthologous to human NYAP1 (neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 38.4), CNS E18 (RPKM 37.3) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Nyap1 in Genome Data Viewer
Location:
5; 5 G2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137729144..137739430, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137730882..137741168, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with FG repeats 2 Neighboring gene predicted gene, 54308 Neighboring gene predicted gene 15753 Neighboring gene sperm acrosome developmental regulator Neighboring gene protein phosphatase 1, regulatory subunit 35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nyap1 Regulates Multipolar-Bipolar Transition and Morphology of Migrating Neurons by Fyn Phosphorylation during Corticogenesis. Wang S, et al. Cereb Cortex, 2020 Mar 14. PMID 31609430
  2. The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. Lin JC, et al. Nat Neurosci, 2003 Dec. PMID 14595443
  3. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. Yokoyama K, et al. EMBO J, 2011 Sep 23. PMID 21946561, Free PMC Article
  4. Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter. Kurz J, et al. Development, 2022 Feb 15. PMID 35103284
  5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

See all (18) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in neuron projection morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1
Names
neuronal tyrosine phosphorylated adaptor for phosphoinositide 3-kinase adaptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347505.1 → NP_001334434.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC124730, AC125063
    Consensus CDS
    CCDS84980.1
    UniProtKB/Swiss-Prot
    Q6PFX7
    Related
    ENSMUSP00000148318.2, ENSMUST00000212152.2
    Conserved Domains (2) summary
    pfam15439
    Location:4 → 413
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:577 → 832
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

  2. NM_175521.4 → NP_780730.2  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform 1

    See identical proteins and their annotated locations for NP_780730.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK032567, BC057372, CJ292493
    Consensus CDS
    CCDS19775.1
    UniProtKB/Swiss-Prot
    Q6PFX7, Q8CCL6
    Related
    ENSMUSP00000113397.2, ENSMUST00000118326.8
    Conserved Domains (2) summary
    pfam15439
    Location:15 → 410
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:571 → 833
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137729144..137739430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504576.5 → XP_006504639.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1

    See identical proteins and their annotated locations for XP_006504639.1

    UniProtKB/Swiss-Prot
    Q6PFX7
    Conserved Domains (2) summary
    pfam15439
    Location:4 → 413
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:577 → 832
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

  2. XM_006504577.5 → XP_006504640.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1

    See identical proteins and their annotated locations for XP_006504640.1

    UniProtKB/Swiss-Prot
    Q6PFX7
    Conserved Domains (2) summary
    pfam15439
    Location:4 → 413
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:577 → 832
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PFX7.1 GenPept UniProtKB/Swiss-Prot:Q6PFX7

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