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ALOX12B arachidonate 12-lipoxygenase, 12R type [ Homo sapiens (human) ]

Gene ID: 242, updated on 1-Jun-2020

Summary

Official Symbol
ALOX12Bprovided by HGNC
Official Full Name
arachidonate 12-lipoxygenase, 12R typeprovided by HGNC
Primary source
HGNC:HGNC:430
See related
Ensembl:ENSG00000179477 MIM:603741
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARCI2; 12R-LOX
Summary
This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma. [provided by RefSeq, Sep 2015]
Expression
Biased expression in skin (RPKM 26.9) and esophagus (RPKM 2.9) See more
Orthologs

Genomic context

See ALOX12B in Genome Data Viewer
Location:
17p13.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8072636..8087716, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7975954..7991021, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene arachidonate 15-lipoxygenase type B Neighboring gene arachidonate lipoxygenase 3 pseudogene 1 Neighboring gene uncharacterized LOC107985075 Neighboring gene microRNA 4314 Neighboring gene arachidonate lipoxygenase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arachidonate 12-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arachidonate 12-lipoxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
arachidonate 8(R)-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
linoleate 9S-lipoxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arachidonic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
arachidonic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
ceramide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment of skin barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
hepoxilin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hepoxilin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
linoleic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipoxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipoxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
lipoxygenase pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoxygenase pathway TAS
Traceable Author Statement
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein lipidation ISS
Inferred from Sequence or Structural Similarity
more info
 
sphingolipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arachidonate 12-lipoxygenase, 12R-type
Names
12R-lipoxygenase
epidermis-type lipoxygenase 12
NP_001130.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007099.2 RefSeqGene

    Range
    5001..20081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1264

mRNA and Protein(s)

  1. NM_001139.3NP_001130.1  arachidonate 12-lipoxygenase, 12R-type

    See identical proteins and their annotated locations for NP_001130.1

    Status: REVIEWED

    Source sequence(s)
    AC129492, AF059250, BC041058
    Consensus CDS
    CCDS11129.1
    UniProtKB/Swiss-Prot
    O75342
    Related
    ENSP00000497784.1, ENST00000647874.1
    Conserved Domains (2) summary
    cd01753
    Location:2116
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    cl27717
    Location:258681
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8072636..8087716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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