Asic4 acid-sensing ion channel family member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asic4provided by MGI
Official Full Name: acid-sensing ion channel family member 4provided by MGI
Primary source: MGI:MGI:2652846
See related: Ensembl:ENSMUSG00000033007 AllianceGenome:MGI:2652846
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Accn4; BNAC4
Summary: Predicted to enable ligand-gated sodium channel activity. Acts upstream of or within behavioral fear response. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; brain; gut; male reproductive gland or organ; and spinal cord mantle layer. Orthologous to human ASIC4 (acid sensing ion channel subunit family member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 9.0), CNS E14 (RPKM 7.9) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C4; 1 39.08 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (75426467..75450984)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (75450510..75474340)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study employed a radioactive in situ hybridization method to thoroughly investigate the distribution of Acid-sensing ion channel 4 (ASIC4) transcripts in the adult wild-type mouse brain. The resultant data indicate that the ASIC4 mRNAs were substantially expressed in many areas of the brain.
Title: Distribution of ASIC4 transcripts in the adult wild-type mouse brain.
This study demonstrated that ASIC4 may modulate fear and anxiety by counteracting ASIC1a activity in the brain.
Title: Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD06448 (e-PCR)
- UniSTS:287508

RH125051 (e-PCR)
- UniSTS:161873

AI414328 (e-PCR)
- UniSTS:158815

REN53165 (e-PCR)
- UniSTS:377965

REN53166 (e-PCR)
- UniSTS:377966

REN53167 (e-PCR)
- UniSTS:377967

stSG633055 (e-PCR)
- UniSTS:460409

D1Bwg1363e (e-PCR), detects polymorphism
- UniSTS:142230

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: acid-sensing ion channel 4

Names: acid-sensing (proton-gated) ion channel family member 4; amiloride-sensitive cation channel 4, pituitary

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183022.3 → NP_898843.1 acid-sensing ion channel 4

See identical proteins and their annotated locations for NP_898843.1

Status: VALIDATED

Source sequence(s)

BB621654, BC055772, BY652580

Consensus CDS

CCDS15073.1

UniProtKB/Swiss-Prot

Q7TNS7, Q80XK4

UniProtKB/TrEMBL

D3YYS9

Related

ENSMUSP00000045598.10, ENSMUST00000037708.10

Conserved Domains (1) summary

cl02990
Location:40 → 488

ASC; Amiloride-sensitive sodium channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

75426467..75450984

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165009.1 → XP_036020902.1 acid-sensing ion channel 4 isoform X1

UniProtKB/TrEMBL

D3YYS9

Conserved Domains (1) summary

cl02990
Location:40 → 535

ASC; Amiloride-sensitive sodium channel