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Asic4 acid-sensing ion channel family member 4 [ Mus musculus (house mouse) ]

Gene ID: 241118, updated on 8-Feb-2024

Summary

Official Symbol
Asic4provided by MGI
Official Full Name
acid-sensing ion channel family member 4provided by MGI
Primary source
MGI:MGI:2652846
See related
Ensembl:ENSMUSG00000033007 AllianceGenome:MGI:2652846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Accn4; BNAC4
Summary
Predicted to enable ligand-gated sodium channel activity. Acts upstream of or within behavioral fear response. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adrenal gland; brain; gut; male reproductive gland or organ; and spinal cord mantle layer. Orthologous to human ASIC4 (acid sensing ion channel subunit family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 9.0), CNS E14 (RPKM 7.9) and 7 other tissues See more
Orthologs
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Genomic context

See Asic4 in Genome Data Viewer
Location:
1 C4; 1 39.08 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75426467..75450984)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75450510..75474340)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene SPEG complex locus Neighboring gene STARR-seq mESC enhancer starr_01359 Neighboring gene GDP-mannose pyrophosphorylase A Neighboring gene predicted gene, 53564 Neighboring gene predicted gene, 32506 Neighboring gene STARR-positive B cell enhancer ABC_E1997 Neighboring gene transmembrane protein 198 Neighboring gene chondroitin polymerizing factor Neighboring gene STARR-seq mESC enhancer starr_01360 Neighboring gene obscurin-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acid-sensing ion channel 4
Names
acid-sensing (proton-gated) ion channel family member 4
amiloride-sensitive cation channel 4, pituitary

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183022.3NP_898843.1  acid-sensing ion channel 4

    See identical proteins and their annotated locations for NP_898843.1

    Status: VALIDATED

    Source sequence(s)
    BB621654, BC055772, BY652580
    Consensus CDS
    CCDS15073.1
    UniProtKB/Swiss-Prot
    Q7TNS7, Q80XK4
    UniProtKB/TrEMBL
    D3YYS9
    Related
    ENSMUSP00000045598.10, ENSMUST00000037708.10
    Conserved Domains (1) summary
    cl02990
    Location:40488
    ASC; Amiloride-sensitive sodium channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    75426467..75450984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165009.1XP_036020902.1  acid-sensing ion channel 4 isoform X1

    UniProtKB/TrEMBL
    D3YYS9
    Conserved Domains (1) summary
    cl02990
    Location:40535
    ASC; Amiloride-sensitive sodium channel