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Synj2bp synaptojanin 2 binding protein [ Mus musculus (house mouse) ]

Gene ID: 24071, updated on 5-Mar-2024

Summary

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Official Symbol
Synj2bpprovided by MGI
Official Full Name
synaptojanin 2 binding proteinprovided by MGI
Primary source
MGI:MGI:1344347
See related
Ensembl:ENSMUSG00000090935 AllianceGenome:MGI:1344347
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARIP2; OMP25; ActRIP4; D12Wsu118e
Summary
Enables type II activin receptor binding activity. Involved in positive regulation of protein localization to cell surface; positive regulation of receptor internalization; and regulation of activin receptor signaling pathway. Acts upstream of or within Rho protein signal transduction; protein targeting; and regulation of endocytosis. Located in cell surface. Is expressed in several structures, including blood vessel; extraembryonic component; genitourinary system; neural tube; and retina. Orthologous to human SYNJ2BP (synaptojanin 2 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 3.6), bladder adult (RPKM 3.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Synj2bp in Genome Data Viewer
Location:
12 D1; 12 37.73 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81538968..81579685, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81492194..81532911, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene synaptojanin 2 binding protein Cox16 readthrough Neighboring gene cytochrome c oxidase assembly protein 16 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_32671 Neighboring gene STARR-seq mESC enhancer starr_32672 Neighboring gene a disintegrin and metallopeptidase domain 4 Neighboring gene STARR-seq mESC enhancer starr_32673 Neighboring gene STARR-positive B cell enhancer ABC_E9388 Neighboring gene STARR-positive B cell enhancer ABC_E7157 Neighboring gene STARR-seq mESC enhancer starr_32674 Neighboring gene a disintegrin and metallopeptidase domain 21 Neighboring gene mediator complex subunit 6 Neighboring gene 40S ribosomal protein S23 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of Synj2bp in mouse liver regulates the extent of wrappER-mitochondria contact to maintain hepatic lipid homeostasis. Ilacqua N, et al. Biol Direct, 2022 Dec 1. PMID 36457006, Free PMC Article
  2. Expression and localization of activin receptor-interacting protein 2 in mouse tissues. Liu HY, et al. Gen Comp Endocrinol, 2009 Apr. PMID 19523381
  3. Regulation of activin receptor-interacting protein 2 expression in mouse hepatoma Hepa1-6 cells and its relationship with collagen type IV. Zhang HJ, et al. World J Gastroenterol, 2007 Nov 7. PMID 17907296, Free PMC Article
  4. Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway. Yagita Y, et al. J Cell Biol, 2013 Mar 4. PMID 23460677, Free PMC Article
  5. Characterization of isoforms of activin receptor-interacting protein 2 that augment activin signaling. Liu ZH, et al. J Endocrinol, 2006 May. PMID 16648306

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of Synj2bp in mouse liver regulates the extent of wrappER-mitochondria contact to maintain hepatic lipid homeostasis.
    Title: Expression of Synj2bp in mouse liver regulates the extent of wrappER-mitochondria contact to maintain hepatic lipid homeostasis.
  2. The findings suggest that ARIP2 is widely distributed in various tissues and may be a negative regulator of activin action in pituitary cells.
    Title: Expression and localization of activin receptor-interacting protein 2 in mouse tissues.
  3. ARIP2 expression can be influenced by various factors. ARIP2 may participate in the negative feedback regulation of signal transduction in the late stage by affecting the expression of activin type 2 receptor.
    Title: Regulation of activin receptor-interacting protein 2 expression in mouse hepatoma Hepa1-6 cells and its relationship with collagen type IV.
  4. Overexpression of ARIP2 enhances endocytosis of ActRIIAs; data indicate that ARIP2 is a novel factor regulating cell surface ActRIIA expression and activin function.
    Title: Novel factors in regulation of activin signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables type II activin receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Rho protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cytoplasm organization ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in intracellular distribution of mitochondria ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of activin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of activin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein targeting IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in regulation of receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
synaptojanin-2-binding protein
Names
activin receptor interacting protein 2
activin receptor-interacting protein 4
mitochondrial outer membrane protein 25
outer membrane protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309814.1 → NP_001296743.1  synaptojanin-2-binding protein isoform 2

    See identical proteins and their annotated locations for NP_001296743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as ARIP2c) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY071903, AY566156, BY745220
    Consensus CDS
    CCDS83979.1
    UniProtKB/Swiss-Prot
    Q9D6K5
    Related
    ENSMUSP00000130691.2, ENSMUST00000169158.2
    Conserved Domains (1) summary
    cd00992
    Location:13 → 97
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. NM_025292.7 → NP_079568.1  synaptojanin-2-binding protein isoform 1

    See identical proteins and their annotated locations for NP_079568.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC132391, AC154908, AI851233, AK163362, BY745220
    Consensus CDS
    CCDS26021.1
    UniProtKB/Swiss-Prot
    Q2TTN6, Q6YNE6, Q78HT9, Q8K4F3, Q9D6K5, Q9D8G4
    Related
    ENSMUSP00000129224.2, ENSMUST00000163402.8
    Conserved Domains (1) summary
    cd00992
    Location:13 → 97
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RNA

  1. NR_132136.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC132391, AC154908, AI851233, AK030379, BY745220

  2. NR_132142.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AY071903, AY566156, BY745220

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    81538968..81579685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6K5.1 GenPept UniProtKB/Swiss-Prot:Q9D6K5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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