U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rnasel ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) [ Mus musculus (house mouse) ]

Gene ID: 24014, updated on 14-May-2024

Summary

Official Symbol
Rnaselprovided by MGI
Official Full Name
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)provided by MGI
Primary source
MGI:MGI:1098272
See related
Ensembl:ENSMUSG00000066800 AllianceGenome:MGI:1098272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E230029I04Rik
Summary
Enables ribonucleoprotein complex binding activity. Acts upstream of or within fat cell differentiation; positive regulation of glucose import; and regulation of mRNA stability. Predicted to be located in nuclear matrix. Is expressed in cerebellum; embryo; hippocampus; retina inner nuclear layer; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate cancer. Orthologous to human RNASEL (ribonuclease L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 11.6), CNS E11.5 (RPKM 9.8) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rnasel in Genome Data Viewer
Location:
1 G3; 1 65.43 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (153625089..153644441)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (153749344..153768690)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C230024C17 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:155593298-155593499 Neighboring gene STARR-positive B cell enhancer ABC_E5824 Neighboring gene STARR-positive B cell enhancer ABC_E9185 Neighboring gene STARR-positive B cell enhancer mm9_chr1:155598826-155599127 Neighboring gene regulator of G-protein signaling 16 Neighboring gene regulator of G-protein signaling like 1 Neighboring gene predicted gene, 41974 Neighboring gene zinc finger protein 799 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA nuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA nuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables rRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
2-5A-dependent ribonuclease
Names
2-5A-dependent RNAase
2-5A-dependent RNase
RNase L
ribonuclease 4
NP_036012.1
XP_006529590.1
XP_006529591.1
XP_011246295.1
XP_030109810.1
XP_030109811.1
XP_030109813.1
XP_036020559.1
XP_036020560.1
XP_036020561.1
XP_036020562.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011882.2NP_036012.1  2-5A-dependent ribonuclease

    See identical proteins and their annotated locations for NP_036012.1

    Status: VALIDATED

    Source sequence(s)
    AC154140, AK140815, BC138013
    Consensus CDS
    CCDS15377.1
    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Related
    ENSMUSP00000083385.4, ENSMUST00000086209.10
    Conserved Domains (5) summary
    cd10423
    Location:588707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:5989
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:2988
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61298
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    153625089..153644441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164669.1XP_036020562.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    S4R2R4
    Conserved Domains (5) summary
    sd00045
    Location:5989
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:2988
    Ank_2; Ankyrin repeats (3 copies)
    cl15368
    Location:588680
    RNase_Ire1_like; RNase domain (also known as the kinase extension nuclease domain) of Ire1 and RNase L
    cl21453
    Location:361585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61298
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_036164666.1XP_036020559.1  2-5A-dependent ribonuclease isoform X1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Conserved Domains (5) summary
    cd10423
    Location:588707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:5989
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:2988
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61298
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_036164667.1XP_036020560.1  2-5A-dependent ribonuclease isoform X1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Related
    ENSMUSP00000138752.2, ENSMUST00000183241.8
    Conserved Domains (5) summary
    cd10423
    Location:588707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:5989
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:2988
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61298
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_030253953.2XP_030109813.1  2-5A-dependent ribonuclease isoform X1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Conserved Domains (5) summary
    cd10423
    Location:588707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:5989
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:2988
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61298
    Ank_2; Ankyrin repeats (3 copies)
  5. XM_030253950.2XP_030109810.1  2-5A-dependent ribonuclease isoform X1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Conserved Domains (5) summary
    cd10423
    Location:588707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:5989
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:2988
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61298
    Ank_2; Ankyrin repeats (3 copies)
  6. XM_030253951.2XP_030109811.1  2-5A-dependent ribonuclease isoform X1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Conserved Domains (5) summary
    cd10423
    Location:588707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:5989
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:2988
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61298
    Ank_2; Ankyrin repeats (3 copies)
  7. XM_006529528.5XP_006529591.1  2-5A-dependent ribonuclease isoform X1

    See identical proteins and their annotated locations for XP_006529591.1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Conserved Domains (5) summary
    cd10423
    Location:588707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:5989
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:2988
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61298
    Ank_2; Ankyrin repeats (3 copies)
  8. XM_036164668.1XP_036020561.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    S4R2R4
    Conserved Domains (5) summary
    sd00045
    Location:5989
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:2988
    Ank_2; Ankyrin repeats (3 copies)
    cl15368
    Location:588680
    RNase_Ire1_like; RNase domain (also known as the kinase extension nuclease domain) of Ire1 and RNase L
    cl21453
    Location:361585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61298
    Ank_2; Ankyrin repeats (3 copies)
  9. XM_011247993.4XP_011246295.1  2-5A-dependent ribonuclease isoform X1

    See identical proteins and their annotated locations for XP_011246295.1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Conserved Domains (5) summary
    cd10423
    Location:588707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:5989
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:2988
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61298
    Ank_2; Ankyrin repeats (3 copies)
  10. XM_006529527.5XP_006529590.1  2-5A-dependent ribonuclease isoform X1

    See identical proteins and their annotated locations for XP_006529590.1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Conserved Domains (5) summary
    cd10423
    Location:588707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:5989
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:2988
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61298
    Ank_2; Ankyrin repeats (3 copies)