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Rnasel ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) [ Mus musculus (house mouse) ]

Gene ID: 24014, updated on 2-Nov-2024

Summary

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Official Symbol
Rnaselprovided by MGI
Official Full Name
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)provided by MGI
Primary source
MGI:MGI:1098272
See related
Ensembl:ENSMUSG00000066800 AllianceGenome:MGI:1098272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E230029I04Rik
Summary
Enables ribonucleoprotein complex binding activity. Acts upstream of or within fat cell differentiation; positive regulation of D-glucose import; and regulation of mRNA stability. Predicted to be located in nuclear matrix. Is expressed in several structures, including brain and retina nuclear layer. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate cancer. Orthologous to human RNASEL (ribonuclease L). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E14 (RPKM 11.6), CNS E11.5 (RPKM 9.8) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Rnasel in Genome Data Viewer
Location:
1 G3; 1 65.43 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (153625089..153644441)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (153749344..153768690)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C230024C17 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:155593298-155593499 Neighboring gene STARR-positive B cell enhancer ABC_E5824 Neighboring gene STARR-positive B cell enhancer ABC_E9185 Neighboring gene STARR-positive B cell enhancer mm9_chr1:155598826-155599127 Neighboring gene regulator of G-protein signaling 16 Neighboring gene regulator of G-protein signaling like 1 Neighboring gene predicted gene, 41974 Neighboring gene zinc finger protein 799 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Small self-RNA generated by RNase L amplifies antiviral innate immunity. Malathi K, et al. Nature, 2007 Aug 16. PMID 17653195, Free PMC Article
  2. Lack of RNase L attenuates macrophage functions. Yi X, et al. PLoS One, 2013. PMID 24324683, Free PMC Article
  3. Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity. Zhang R, et al. Proc Natl Acad Sci U S A, 2013 Aug 6. PMID 23878220, Free PMC Article
  4. Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L. Sorgeloos F, et al. PLoS Pathog, 2013. PMID 23825954, Free PMC Article
  5. Cell-type-specific activation of the oligoadenylate synthetase-RNase L pathway by a murine coronavirus. Zhao L, et al. J Virol, 2013 Aug. PMID 23698313, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unraveling the Role of RNase L Knockout in Alleviating Immune Response Activation in Mice Bone Marrow after Irradiation.
    Title: Unraveling the Role of RNase L Knockout in Alleviating Immune Response Activation in Mice Bone Marrow after Irradiation.
  2. A novel role of RNase L in the development of nonalcoholic steatohepatitis.
    Title: A novel role of RNase L in the development of nonalcoholic steatohepatitis.
  3. The function of RNase L and its degradation mechanism in cardiac acute ischemic injury.
    Title: The function of RNase L and its degradation mechanism in cardiac acute ischemic injury.
  4. Pref-1 mRNA is a novel substrate of RNase-L.
    Title: A link between adipogenesis and innate immunity: RNase-L promotes 3T3-L1 adipogenesis by destabilizing Pref-1 mRNA.
  5. RNAse L stimulates fibroblast migration.
    Title: RNase L is a negative regulator of cell migration.
  6. Thus, activation of RNase L does not require mouse hepatitis virus virus-induced interferon but rather correlates with adequate levels of basal Oas gene expression, maintained by basal interferon signaling.
    Title: Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.
  7. Thus, RNA cleavage events catalyzed by RNase L are required for optimal inflammasome activation during viral infections.
    Title: RNase L activates the NLRP3 inflammasome during viral infections.
  8. cellular functions of RNase L through protein-protein interactions in the spleen for immune response in mammals
    Title: Expression of mRNA and protein-protein interaction of the antiviral endoribonuclease RNase L in mouse spleen.
  9. Data indicate that deficiency of 2-5A-dependent RNase L (RNase L) in resulted in a significant delay of diabetes onset.
    Title: RNase L contributes to experimentally induced type 1 diabetes onset in mice.
  10. RNase L contributes to innate immunity through regulating macrophage functions.
    Title: Lack of RNase L attenuates macrophage functions.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA nuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA nuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fat cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral genome replication IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of D-glucose import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
2-5A-dependent ribonuclease
Names
2-5A-dependent RNAase
2-5A-dependent RNase
RNase L
ribonuclease 4
NP_036012.1
XP_006529590.1
XP_006529591.1
XP_011246295.1
XP_030109810.1
XP_030109811.1
XP_030109813.1
XP_036020559.1
XP_036020560.1
XP_036020561.1
XP_036020562.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011882.2 → NP_036012.1  2-5A-dependent ribonuclease

    See identical proteins and their annotated locations for NP_036012.1

    Status: VALIDATED

    Source sequence(s)
    AC154140, AK140815, BC138013
    Consensus CDS
    CCDS15377.1
    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Related
    ENSMUSP00000083385.4, ENSMUST00000086209.10
    Conserved Domains (5) summary
    cd10423
    Location:588 → 707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:29 → 88
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361 → 585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61 → 298
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    153625089..153644441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164669.1 → XP_036020562.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    S4R2R4
    Conserved Domains (5) summary
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:29 → 88
    Ank_2; Ankyrin repeats (3 copies)
    cl15368
    Location:588 → 680
    RNase_Ire1_like; RNase domain (also known as the kinase extension nuclease domain) of Ire1 and RNase L
    cl21453
    Location:361 → 585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61 → 298
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_036164666.1 → XP_036020559.1  2-5A-dependent ribonuclease isoform X1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Conserved Domains (5) summary
    cd10423
    Location:588 → 707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:29 → 88
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361 → 585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61 → 298
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_036164667.1 → XP_036020560.1  2-5A-dependent ribonuclease isoform X1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Related
    ENSMUSP00000138752.2, ENSMUST00000183241.8
    Conserved Domains (5) summary
    cd10423
    Location:588 → 707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:29 → 88
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361 → 585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61 → 298
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_030253953.2 → XP_030109813.1  2-5A-dependent ribonuclease isoform X1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Conserved Domains (5) summary
    cd10423
    Location:588 → 707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:29 → 88
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361 → 585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61 → 298
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_030253950.2 → XP_030109810.1  2-5A-dependent ribonuclease isoform X1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Conserved Domains (5) summary
    cd10423
    Location:588 → 707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:29 → 88
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361 → 585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61 → 298
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_030253951.2 → XP_030109811.1  2-5A-dependent ribonuclease isoform X1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Conserved Domains (5) summary
    cd10423
    Location:588 → 707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:29 → 88
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361 → 585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61 → 298
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_006529528.5 → XP_006529591.1  2-5A-dependent ribonuclease isoform X1

    See identical proteins and their annotated locations for XP_006529591.1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Conserved Domains (5) summary
    cd10423
    Location:588 → 707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:29 → 88
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361 → 585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61 → 298
    Ank_2; Ankyrin repeats (3 copies)

  8. XM_036164668.1 → XP_036020561.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    S4R2R4
    Conserved Domains (5) summary
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:29 → 88
    Ank_2; Ankyrin repeats (3 copies)
    cl15368
    Location:588 → 680
    RNase_Ire1_like; RNase domain (also known as the kinase extension nuclease domain) of Ire1 and RNase L
    cl21453
    Location:361 → 585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61 → 298
    Ank_2; Ankyrin repeats (3 copies)

  9. XM_011247993.4 → XP_011246295.1  2-5A-dependent ribonuclease isoform X1

    See identical proteins and their annotated locations for XP_011246295.1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Conserved Domains (5) summary
    cd10423
    Location:588 → 707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:29 → 88
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361 → 585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61 → 298
    Ank_2; Ankyrin repeats (3 copies)

  10. XM_006529527.5 → XP_006529590.1  2-5A-dependent ribonuclease isoform X1

    See identical proteins and their annotated locations for XP_006529590.1

    UniProtKB/Swiss-Prot
    Q05921, Q9ERU7
    UniProtKB/TrEMBL
    B2RQP1, S4UWW3
    Conserved Domains (5) summary
    cd10423
    Location:588 → 707
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:29 → 88
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:361 → 585
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:61 → 298
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05921.2 GenPept UniProtKB/Swiss-Prot:Q05921

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