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Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 [ Mus musculus (house mouse) ]

Gene ID: 23996, updated on 8-Feb-2024

Summary

Official Symbol
Psmc4provided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, ATPase, 4provided by MGI
Primary source
MGI:MGI:1346093
See related
Ensembl:ENSMUSG00000030603 AllianceGenome:MGI:1346093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CIP21; MIP224
Summary
Predicted to enable proteasome-activating activity. Acts upstream of or within blastocyst development. Part of proteasome accessory complex. Is expressed in several structures, including alimentary system; cranial ganglion; early conceptus; gonad; and liver lobe. Used to study amyotrophic lateral sclerosis. Orthologous to human PSMC4 (proteasome 26S subunit, ATPase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 88.1), CNS E14 (RPKM 71.4) and 28 other tissues See more
Orthologs
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Genomic context

See Psmc4 in Genome Data Viewer
Location:
7 A3; 7 16.11 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27741127..27749517, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28041702..28050092, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, pseudogene 87 Neighboring gene zinc finger protein 850 Neighboring gene STARR-positive B cell enhancer ABC_E1084 Neighboring gene STARR-seq mESC enhancer starr_18400 Neighboring gene Fc fragment of IgG binding protein Neighboring gene tectorin alpha pseudogene Neighboring gene predicted gene, 38976 Neighboring gene predicted gene, 24356

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC103150

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables proteasome-activating activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of cytosolic proteasome complex ISO
Inferred from Sequence Orthology
more info
 
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome accessory complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
26S proteasome regulatory subunit 6B
Names
26S protease regulatory subunit 6B
26S proteasome AAA-ATPase subunit RPT3
CAR interacing protein 21
CAR interacting protein 21
MB67-interacting protein
TAT-binding protein 7
TBP-7
proteasome 26S ATPase subunit 4
proteasome 26S subunit ATPase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011874.2NP_036004.2  26S proteasome regulatory subunit 6B

    See identical proteins and their annotated locations for NP_036004.2

    Status: VALIDATED

    Source sequence(s)
    AK077507, BY385516, DV646128
    Consensus CDS
    CCDS21034.1
    UniProtKB/Swiss-Prot
    P54775, Q6ZWN9
    UniProtKB/TrEMBL
    Q3TFA5, Q569X4, Q8BKU2
    Related
    ENSMUSP00000032824.10, ENSMUST00000032824.10
    Conserved Domains (1) summary
    PTZ00454
    Location:34418
    PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27741127..27749517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)