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ALOX12 arachidonate 12-lipoxygenase, 12S type [ Homo sapiens (human) ]

Gene ID: 239, updated on 11-Sep-2019

Summary

Official Symbol
ALOX12provided by HGNC
Official Full Name
arachidonate 12-lipoxygenase, 12S typeprovided by HGNC
Primary source
HGNC:HGNC:429
See related
Ensembl:ENSG00000108839 MIM:152391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LOG12; 12-LOX; 12S-LOX
Summary
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
Expression
Broad expression in esophagus (RPKM 11.1), skin (RPKM 5.2) and 15 other tissues See more
Orthologs

Genomic context

See ALOX12 in Genome Data Viewer
Location:
17p13.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (6993791..7010754)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6899384..6914055)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene arachidonate 12-lipoxygenase pseudogene 2 Neighboring gene Spi-C transcription factor (Spi-1/PU.1 related) pseudogene Neighboring gene ALOX12 antisense RNA 1 Neighboring gene RNASEK-C17orf49 readthrough Neighboring gene chromosome 17 open reading frame 49 Neighboring gene mir-497-195 cluster host gene Neighboring gene ribonuclease K

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Antifolate resistance, organism-specific biosystem (from KEGG)
    Antifolate resistance, organism-specific biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
  • Antifolate resistance, conserved biosystem (from KEGG)
    Antifolate resistance, conserved biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
  • Arachidonic acid metabolism, organism-specific biosystem (from KEGG)
    Arachidonic acid metabolism, organism-specific biosystem
    Arachidonic acid metabolism
  • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
    Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
  • Arachidonic acid metabolism, conserved biosystem (from KEGG)
    Arachidonic acid metabolism, conserved biosystem
    Arachidonic acid metabolism
  • Eicosanoid Synthesis, organism-specific biosystem (from WikiPathways)
    Eicosanoid Synthesis, organism-specific biosystemIn biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or i...
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Serotonergic synapse, organism-specific biosystem (from KEGG)
    Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
  • Synthesis of 12-eicosatetraenoic acid derivatives, organism-specific biosystem (from REACTOME)
    Synthesis of 12-eicosatetraenoic acid derivatives, organism-specific biosystemThe 12-eicosatetraenoic acids: 12-hydroperoxy-eicosatetraenoic acid (12-HpETE), 12-hydroxyeicosatetraenoic acid (12-HETE) and 12-oxo-eicosatetraenoic acid (12-oxoETE) are formed after the initial ste...
  • Synthesis of Hepoxilins (HX) and Trioxilins (TrX), organism-specific biosystem (from REACTOME)
    Synthesis of Hepoxilins (HX) and Trioxilins (TrX), organism-specific biosystemHepoxilins are biologically relevant signalling molecules produced by certain arachidonate 12-lipoxygenase (ALOX12s). Hepoxilin A3 (HXA3) and B3 (HXB3) have been identified, both of which incorporate...
  • Synthesis of Lipoxins (LX), organism-specific biosystem (from REACTOME)
    Synthesis of Lipoxins (LX), organism-specific biosystemLipoxins A4 (LXA4) and B4 (LXB4), structurally characterized from human neutrophils incubated with 15-hydroperoxy-eicosatetraenoic acid (15-HpETE), each contain three hydroxyl moieties and a conjugat...
  • lipoxin biosynthesis, organism-specific biosystem (from BIOCYC)
    lipoxin biosynthesis, organism-specific biosystemGeneral Background Lipoxins belong to the eicosanoid family, have a distinct conjugated tetraene structure and are generated from : ARACHIDONIC_ACID during inflammation. They consist of two distinct...
  • lipoxin biosynthesis, conserved biosystem (from BIOCYC)
    lipoxin biosynthesis, conserved biosystemGeneral Background Lipoxins belong to the eicosanoid family, have a distinct conjugated tetraene structure and are generated from |FRAME: ARACHIDONIC_ACID| during inflammation. They consist of two d...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arachidonate 12-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
hepoxilin-epoxide hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
linoleate 13S-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
arachidonic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to lipid IEA
Inferred from Electronic Annotation
more info
 
establishment of skin barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hepoxilin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
hepoxilin metabolic process TAS
Traceable Author Statement
more info
 
leukotriene A4 metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
NOT leukotriene A4 metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
NOT linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lipoxin A4 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
lipoxin B4 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
lipoxin biosynthetic process TAS
Traceable Author Statement
more info
 
lipoxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
lipoxygenase pathway TAS
Traceable Author Statement
more info
 
long-chain fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 
negative regulation of muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of platelet aggregation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of blood vessel diameter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial tube morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial depolarization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
superoxide anion generation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arachidonate 12-lipoxygenase, 12S-type
Names
12S-lipoxygenase
lipoxin synthase 12-LO
platelet 12-LOX
platelet-type 12-lipoxygenase
platelet-type lipoxygenase 12
NP_000688.2
XP_011522082.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000697.3NP_000688.2  arachidonate 12-lipoxygenase, 12S-type

    See identical proteins and their annotated locations for NP_000688.2

    Status: REVIEWED

    Source sequence(s)
    AC040977, M58704
    Consensus CDS
    CCDS11084.1
    UniProtKB/Swiss-Prot
    P18054
    Related
    ENSP00000251535.6, ENST00000251535.11
    Conserved Domains (2) summary
    cd01753
    Location:2111
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:219654
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    6993791..7010754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523780.2XP_011522082.1  arachidonate 12-lipoxygenase, 12S-type isoform X1

    Conserved Domains (2) summary
    cd01753
    Location:121230
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:390704
    Lipoxygenase; Lipoxygenase
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