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ALOX12 arachidonate 12-lipoxygenase, 12S type [ Homo sapiens (human) ]

Gene ID: 239, updated on 29-Mar-2020

Summary

Official Symbol
ALOX12provided by HGNC
Official Full Name
arachidonate 12-lipoxygenase, 12S typeprovided by HGNC
Primary source
HGNC:HGNC:429
See related
Ensembl:ENSG00000108839 MIM:152391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LOG12; 12-LOX; 12S-LOX
Summary
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
Expression
Broad expression in esophagus (RPKM 11.1), skin (RPKM 5.2) and 15 other tissues See more
Orthologs

Genomic context

See ALOX12 in Genome Data Viewer
Location:
17p13.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (6993791..7010754)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6899384..6914055)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene arachidonate 12-lipoxygenase pseudogene 2 Neighboring gene Spi-C transcription factor (Spi-1/PU.1 related) pseudogene Neighboring gene ALOX12 antisense RNA 1 Neighboring gene RNASEK-C17orf49 readthrough Neighboring gene chromosome 17 open reading frame 49 Neighboring gene mir-497-195 cluster host gene Neighboring gene ribonuclease K

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arachidonate 12-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arachidonate 12-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
arachidonate 15-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arachidonate 15-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
hepoxilin-epoxide hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
linoleate 13S-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
linoleate 13S-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
arachidonic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to lipid IEA
Inferred from Electronic Annotation
more info
 
establishment of skin barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid oxidation IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hepoxilin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hepoxilin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
hepoxilin metabolic process TAS
Traceable Author Statement
more info
 
leukotriene A4 metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
NOT leukotriene A4 metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
NOT linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipoxin A4 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
lipoxin B4 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
lipoxin biosynthetic process TAS
Traceable Author Statement
more info
 
lipoxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipoxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
lipoxygenase pathway TAS
Traceable Author Statement
more info
 
long-chain fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 
negative regulation of muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of platelet aggregation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of blood vessel diameter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial tube morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial depolarization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
superoxide anion generation NAS
Non-traceable Author Statement
more info
PubMed 
unsaturated fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arachidonate 12-lipoxygenase, 12S-type
Names
12S-lipoxygenase
arachidonate 15-lipoxygenase,15S-type
linoleate 13S-lipoxygenase
lipoxin synthase 12-LO
platelet 12-LOX
platelet-type 12-lipoxygenase
platelet-type lipoxygenase 12
NP_000688.2
XP_011522082.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000697.3NP_000688.2  arachidonate 12-lipoxygenase, 12S-type

    See identical proteins and their annotated locations for NP_000688.2

    Status: REVIEWED

    Source sequence(s)
    AC040977, M58704
    Consensus CDS
    CCDS11084.1
    UniProtKB/Swiss-Prot
    P18054
    Related
    ENSP00000251535.6, ENST00000251535.11
    Conserved Domains (2) summary
    cd01753
    Location:2111
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:219654
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    6993791..7010754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523780.2XP_011522082.1  arachidonate 12-lipoxygenase, 12S-type isoform X1

    Conserved Domains (2) summary
    cd01753
    Location:121230
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:390704
    Lipoxygenase; Lipoxygenase
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