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Amfr autocrine motility factor receptor [ Mus musculus (house mouse) ]

Gene ID: 23802, updated on 28-Oct-2021

Summary

Official Symbol
Amfrprovided by MGI
Official Full Name
autocrine motility factor receptorprovided by MGI
Primary source
MGI:MGI:1345634
See related
Ensembl:ENSMUSG00000031751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gp78
Expression
Ubiquitous expression in adrenal adult (RPKM 95.7), liver adult (RPKM 63.4) and 28 other tissues See more
Orthologs
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Genomic context

See Amfr in Genome Data Viewer
Location:
8 C5; 8 45.96 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94698216..94739268, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93971588..94012640, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (96495488..96536540, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930488L21 gene Neighboring gene guanine nucleotide binding protein, alpha O Neighboring gene VISTA enhancer mm1458 Neighboring gene predicted gene, 53411 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 21 Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BAT3 complex binding ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of SREBP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Derlin-1 retrotranslocation complex ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase AMFR
Names
AMF receptor
RING-type E3 ubiquitin transferase AMFR
NP_035917.2
XP_017168257.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011787.2NP_035917.2  E3 ubiquitin-protein ligase AMFR

    See identical proteins and their annotated locations for NP_035917.2

    Status: VALIDATED

    Source sequence(s)
    AC138118, AK038442, BU754633, BY742866
    Consensus CDS
    CCDS22533.1
    UniProtKB/Swiss-Prot
    Q9R049
    UniProtKB/TrEMBL
    Q3TCI2
    Related
    ENSMUSP00000052258.7, ENSMUST00000053766.14
    Conserved Domains (3) summary
    COG5243
    Location:82378
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd14421
    Location:454494
    CUE_AMFR; CUE domain found in autocrine motility factor receptor (AMFR) and similar proteins
    pfam13639
    Location:335375
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    94698216..94739268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312768.3XP_017168257.1  E3 ubiquitin-protein ligase AMFR isoform X1

    Conserved Domains (4) summary
    COG5243
    Location:5304
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd14421
    Location:380420
    CUE_AMFR; CUE domain found in autocrine motility factor receptor (AMFR) and similar proteins
    cd16455
    Location:261304
    RING-H2_AMFR; RING finger, H2 subclass, found in autocrine motility factor receptor (AMFR) and similar proteins
    pfam18442
    Location:497522
    G2BR; E3 gp78 Ube2g2-binding region (G2BR)
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