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Akt3 thymoma viral proto-oncogene 3 [ Mus musculus (house mouse) ]

Gene ID: 23797, updated on 23-Nov-2023

Summary

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Official Symbol
Akt3provided by MGI
Official Full Name
thymoma viral proto-oncogene 3provided by MGI
Primary source
MGI:MGI:1345147
See related
Ensembl:ENSMUSG00000019699 AllianceGenome:MGI:1345147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nmf350; D930002M15Rik
Summary
Predicted to enable ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of angiogenesis and positive regulation of artery morphogenesis. Acts upstream of or within several processes, including brain morphogenesis; positive regulation of TOR signaling; and positive regulation of cell size. Predicted to be located in plasma membrane. Is expressed in several structures, including genitourinary system; musculature; nervous system; retina; and skin. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 12.2), CNS E14 (RPKM 10.5) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Akt3 in Genome Data Viewer
Location:
1 H4; 1 82.66 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (176847642..177091688, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (177020076..177261781, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene serologically defined colon cancer antigen 8 Neighboring gene high mobility group AT-hook 2, pseudogene 1 Neighboring gene predicted gene, 38158 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:178876211-178876412 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:178880303-178880504 Neighboring gene predicted gene 15423 Neighboring gene predicted gene, 36904 Neighboring gene zinc finger and BTB domain containing 18 Neighboring gene keratin 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Akt3-Mediated Protection Against Inflammatory Demyelinating Disease. DuBois JC, et al. Front Immunol, 2019. PMID 31404142, Free PMC Article
  2. AKT3 drives adenoid cystic carcinoma development in salivary glands. Zboray K, et al. Cancer Med, 2018 Feb. PMID 29282901, Free PMC Article
  3. PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia. Howell KR, et al. PLoS One, 2017. PMID 28467426, Free PMC Article
  4. Genetic Deletion of Akt3 Induces an Endophenotype Reminiscent of Psychiatric Manifestations in Mice. Bergeron Y, et al. Front Mol Neurosci, 2017. PMID 28442992, Free PMC Article
  5. miR-29 targets Akt3 to reduce proliferation and facilitate differentiation of myoblasts in skeletal muscle development. Wei W, et al. Cell Death Dis, 2013 Jun 13. PMID 23764849, Free PMC Article

See all (129) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in SiO2-Induced Lung Fibrosis.
    Title: miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in SiO(2)-Induced Lung Fibrosis.
  2. The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.
    Title: The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.
  3. Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1.
    Title: Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1.
  4. Akt3-mTOR regulates hippocampal neurogenesis in adult mouse.
    Title: Akt3-mTOR regulates hippocampal neurogenesis in adult mouse.
  5. Circ-AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR-296-3p/E-cadherin signals.
    Title: Circ-AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR-296-3p/E-cadherin signals.
  6. AKT3 deficiency in M2 macrophages impairs cutaneous wound healing by disrupting tissue remodeling.
    Title: AKT3 deficiency in M2 macrophages impairs cutaneous wound healing by disrupting tissue remodeling.
  7. Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox).
    Title: Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox).
  8. Specific Akt Family Members Impair Stress-Mediated Transactivation of Viral Promoters and Enhance Neuronal Differentiation: Important Functions for Maintaining Latency.
    Title: Specific Akt Family Members Impair Stress-Mediated Transactivation of Viral Promoters and Enhance Neuronal Differentiation: Important Functions for Maintaining Latency.
  9. Depletion of Siah1 enhanced Akt3 levels in the soma and axonal tips, eliciting multiple branching.
    Title: SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development.
  10. glial cell line-derived neurotrophic factor (GDNF) was identified as an essential factor for FGSCs self-renewal with a more complicated mechanism: GDNF-GFRA1 activates AKT3 via PI3K or Src family kinase (SFK), and SFK upregulates its target genes, Bcl6b, Etv5, and Lhx1, to promote self-renewal of Female germline stem cells.
    Title: AKT3 Is a Pivotal Molecule of Cadherin-22 and GDNF Family Receptor-α1 Signal Pathways Regulating Self-Renewal in Female Germline Stem Cells.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial genome maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
RAC-gamma serine/threonine-protein kinase
Names
PKB gamma
RAC-PK-gamma
protein kinase Akt-3
protein kinase B gamma
NP_035915.3
XP_006496881.1
XP_006496882.1
XP_011237107.1
XP_030109770.1
XP_030109777.1
XP_036020522.1
XP_036020523.1
XP_036020524.1
XP_036020525.1
XP_036020526.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011785.4 → NP_035915.3  RAC-gamma serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_035915.3

    Status: VALIDATED

    Source sequence(s)
    AC130843, AC163009, AK052953, BF455585, CD578931
    Consensus CDS
    CCDS35799.1
    UniProtKB/Swiss-Prot
    Q9WUA6
    UniProtKB/TrEMBL
    Q6NXW0
    Related
    ENSMUSP00000106790.3, ENSMUST00000111160.9
    Conserved Domains (2) summary
    cd01241
    Location:4 → 110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05593
    Location:132 → 479
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    176847642..177091688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164629.1 → XP_036020522.1  RAC-gamma serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    Q6NXW0
    Conserved Domains (2) summary
    cd01241
    Location:4 → 110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:132 → 438
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006496818.5 → XP_006496881.1  RAC-gamma serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_006496881.1

    UniProtKB/Swiss-Prot
    Q9WUA6
    UniProtKB/TrEMBL
    Q6NXW0
    Related
    ENSMUSP00000106789.2, ENSMUST00000111159.2
    Conserved Domains (2) summary
    cd01241
    Location:4 → 110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05593
    Location:132 → 479
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

  3. XM_036164632.1 → XP_036020525.1  RAC-gamma serine/threonine-protein kinase isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:46 → 292
    PKc_like; Protein Kinases, catalytic domain

  4. XM_036164631.1 → XP_036020524.1  RAC-gamma serine/threonine-protein kinase isoform X6

    Conserved Domains (1) summary
    cd05593
    Location:16 → 363
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

  5. XM_036164630.1 → XP_036020523.1  RAC-gamma serine/threonine-protein kinase isoform X5

    Conserved Domains (2) summary
    cl17171
    Location:1 → 49
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:71 → 377
    PKc_like; Protein Kinases, catalytic domain

  6. XM_030253917.2 → XP_030109777.1  RAC-gamma serine/threonine-protein kinase isoform X4

    UniProtKB/TrEMBL
    Q6NXW0
    Conserved Domains (2) summary
    cd05593
    Location:71 → 418
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
    cl17171
    Location:1 → 49
    PH-like; Pleckstrin homology-like domain

  7. XM_030253910.1 → XP_030109770.1  RAC-gamma serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    Q9WUA6
    UniProtKB/TrEMBL
    Q6NXW0
    Conserved Domains (2) summary
    cd01241
    Location:4 → 110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05593
    Location:132 → 479
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

  8. XM_036164633.1 → XP_036020526.1  RAC-gamma serine/threonine-protein kinase isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:46 → 292
    PKc_like; Protein Kinases, catalytic domain

  9. XM_006496819.5 → XP_006496882.1  RAC-gamma serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_006496882.1

    UniProtKB/Swiss-Prot
    Q9WUA6
    UniProtKB/TrEMBL
    Q6NXW0
    Conserved Domains (2) summary
    cd01241
    Location:4 → 110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05593
    Location:132 → 479
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

  10. XM_011238805.4 → XP_011237107.1  RAC-gamma serine/threonine-protein kinase isoform X2

    UniProtKB/TrEMBL
    Q6NXW0
    Conserved Domains (2) summary
    cd01241
    Location:4 → 110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:152 → 417
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUA6.1 GenPept UniProtKB/Swiss-Prot:Q9WUA6

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